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Glycan-Based Drug Discovery Solutions

Our Glycan-Based Drug Discovery services are designed to help pharmaceutical and biotechnology companies, as well as academic research institutions, leverage the power of glycomics for therapeutic development. This end-to-end service offering includes precision glycan analysis and high-throughput glycan profiling, supported by translational expertise in glycoprotein characterization and glycoengineering to help you advance your drug discovery and development efforts. Our Glycan-Based Drug Discovery services are suitable for a wide range of therapeutic areas including cancer, immunology, infectious diseases and more.

Problems We Solve

By addressing these challenges, we help our partners discover novel targets and optimize biotherapeutics.

Unmet therapeutic targets: Conventional approaches often overlook glycans, yet abnormal glycosylation is a hallmark of cancer, autoimmune diseases, and infectious disorders.

Complex glycan structures: Glycans are structurally diverse and difficult to analyze without specialized methods, creating barriers in drug R&D.

Batch-to-batch variability in biologics: Inconsistent glycosylation patterns can compromise the safety, efficacy, and regulatory approval of therapeutic proteins.

Lack of glycan-specific expertise: Many drug discovery pipelines lack in-house knowledge or technologies for high-resolution glycan characterization and engineering.

Our Glycan-Based Solutions

01

Glycan Profiling & Analysis

We provide high-resolution analytical solutions to fully characterize glycan structures in therapeutic proteins and biologics.

  • Structural mapping of N-linked, O-linked, and free glycans using LC-MS, CE, and HPLC workflows.
  • Quantitative profiling of glycosylation patterns across disease and control samples.
  • Identification of critical glycan-related quality attributes for regulatory submissions.
02

Target Discovery & Validation

Our team identifies and validates glycan-related biomarkers and therapeutic targets for drug development.

  • Detection of disease-specific glycosylation signatures through advanced glycomics profiling.
  • Analysis of glycan-protein interactions using glycan microarrays and binding assays.
  • Functional validation of glycosyltransferases, glycosidases, and lectins as novel drug targets.
03

Glycoengineering for Biologics

We optimize glycosylation patterns in therapeutic proteins to improve safety, stability, and efficacy.

  • Engineering antibodies with tailored Fc glycosylation for enhanced effector function.
  • Extending circulation half-life of biologics through controlled sialylation and fucosylation.
  • Reducing immunogenicity by designing homogeneous glycoforms with consistent profiles.

We offer custom-designed glycans and glycan analogs to support screening, mechanistic studies, and therapeutic development.

  • Chemoenzymatic synthesis of structurally defined glycans and oligosaccharides.
  • Production of glycan libraries for high-throughput screening applications.
  • Supply of homogeneous glycan standards for assay calibration and quality control.
05

Drug Screening & Lead Optimization

We accelerate the identification of glycan-based drug candidates using advanced screening platforms.

  • High-throughput glycan array technologies for ligand discovery and binding analysis.
  • In silico modeling and molecular docking to guide lead optimization.
  • Preclinical evaluation of glycan-modified compounds for efficacy and safety.
06

Regulatory & Quality Control Support

We ensure your biologics meet global regulatory standards with comprehensive glycan analysis.

  • Batch-to-batch glycosylation consistency testing for biologics and biosimilars.
  • Assessment of glycan-related critical quality attributes (CQAs).
  • Development of validated, GMP-compliant workflows for glycan characterization.

Our Competitive Edge

Choosing our Glycan-Based Drug Discovery services means gaining a partner with both scientific depth and practical expertise.

Comprehensive Expertise: We integrate glycomics, proteomics, and drug development know-how to provide end-to-end solutions from discovery to regulatory support.

Cutting-Edge Technology: Our workflow is powered by state-of-the-art platforms including LC-MS, CE, HPLC, glycan microarrays, and advanced bioinformatics tools.

Customized Solutions: Every project is tailored to your therapeutic area, whether oncology, immunology, infectious disease, or biologics development.

Global R&D Acceleration: By shortening discovery timelines and reducing technical risks, we help pharmaceutical and biotech teams bring glycan-driven therapeutics to market faster.

Collaborative Partnership: Our experts work closely with your in-house team, ensuring knowledge transfer and long-term value beyond a single project.

Fields We Support with Glycan Expertise

Oncology (Cancer Research & Therapy)

  • Identification of tumor-specific glycosylation signatures as diagnostic and prognostic biomarkers.
  • Development of glycan-targeted antibodies, vaccines, and small molecules for cancer treatment.
  • Engineering therapeutic proteins with optimized glycoforms to improve efficacy and reduce side effects.

Immunology & Autoimmune Disorders

  • Modulation of immune cell signaling through glycan-receptor interactions (e.g., Siglecs, lectins).
  • Discovery of glycan-based biomarkers to monitor autoimmune disease activity.
  • Design of glycan-modified biologics to reduce immunogenicity and enhance safety.

Infectious Diseases

  • Targeting pathogen-associated glycans (e.g., viral glycoproteins, bacterial polysaccharides) for vaccines and therapeutics.
  • Blocking host-pathogen interactions mediated by glycans to prevent infection.
  • Rapid profiling of pathogen glycan structures to support diagnostic and therapeutic development.

Biologics & Biosimilars Development

  • Ensuring batch-to-batch consistency of glycosylation in monoclonal antibodies and recombinant proteins.
  • Glycoengineering biologics to enhance stability, half-life, and therapeutic function.
  • Validated glycan characterization workflows.

Neurology & Neurodegenerative Diseases

  • Profiling glycan changes associated with Alzheimer's, Parkinson's, and other neurological disorders.
  • Developing glycan-based biomarkers for early diagnosis and disease monitoring.
  • Exploring glycan-protein interactions in the brain as novel drug targets.

Project Delivery Process

We follow a streamlined, step-by-step workflow to ensure that every glycan-based drug discovery project is handled with precision, efficiency, and transparency.

Requirement Assessment and Project Planning

1Consultation & Project Design

We begin with a detailed discussion of your scientific goals, therapeutic focus, and regulatory requirements, followed by a customized project plan.

Requirement Assessment and Project Planning

2Sample Preparation & Glycan Profiling

Using advanced platforms such as LC-MS, CE, and glycan microarrays, we analyze glycan structures, interactions, and signatures.

Requirement Assessment and Project Planning

3Target Discovery & Validation

Our experts identify disease-relevant glycans, enzymes, or receptors and confirm their functional role in pathology.

Requirement Assessment and Project Planning

4Custom Development & Engineering

We design glycan-optimized biologics, engineer homogeneous glycoforms, or synthesize custom glycans tailored to your project.

Requirement Assessment and Project Planning

5Screening & Optimization

High-throughput screening and computational modeling are used to evaluate and refine lead compounds or therapeutic candidates.

Requirement Assessment and Project Planning

6Quality Control

We provide comprehensive analytical reports and validated datasets.

Requirement Assessment and Project Planning

7Delivery & Support

Final results are presented with clear recommendations, and ongoing consultation ensures smooth integration into your R&D pipeline.

Frequently Asked Questions (FAQs)

1. What is glycan-based drug discovery?

Glycan-based drug discovery focuses on analyzing and leveraging glycosylation and glycan–protein interactions to identify novel therapeutic targets, optimize biologics, and accelerate drug development.

Glycans regulate key biological processes including immune recognition, pathogen entry, and cancer progression. Abnormal glycosylation patterns often serve as disease hallmarks, making glycans powerful targets for diagnostics and therapeutics.

We apply validated analytical workflows (LC-MS, CE, HPLC) under strict quality control standards and deliver reports.

Yes, we offer chemoenzymatic and enzymatic synthesis of defined glycans and analogs, tailored to screening, mechanistic studies, or therapeutic development.

Accelerate Drug Discovery With Us

Expand the impact of glycan-centric drug discovery with a team partner that can support your project with scientific, technological and regulatory strength. BOC Sciences provides glycan profiling, glycoengineering support, high throughput screening, and other tailored solutions to accelerate your pipeline and help you de-risk your program. In addition to glycan analytics and drug discovery services, we also offers off-the-shelf and custom-synthesized glycans ready to assist with N-linked glycans, O-linked glycans, sialylated glycans, fucosylated glycans, glycan analogs and other glycan-based needs, providing you with the necessary components to enable screening, assay development, and drug design.

Contact us today to discuss your project and explore how our Glycan-Based Drug Discovery services can help you move from complex glycan insights to breakthrough therapeutics.

* Only for research. Not suitable for any diagnostic or therapeutic use.
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