webinar
Oct. 27-28, 2025, Boston, MA, USA - Booth 114.
Read More

Glycopeptide Synthesis Service

As a trusted partner in advanced glycobiology research, we provide comprehensive glycopeptide synthesis and analysis services to accelerate your projects. With expertise in glycoconjugate chemistry, peptide engineering, and glycan modifications, our team ensures high-quality, reproducible results tailored to your research or therapeutic development needs. Whether for academic exploration or biopharmaceutical applications, we deliver reliable solutions with precision and efficiency.

What Problems Can Glycopeptide Services Solve?

Complex synthesis challenges - Overcome the technical barriers of attaching glycans to peptides with controlled site-specificity and structural accuracy.

Structure-function studies - Enable detailed investigation of how glycosylation influences peptide folding, stability, binding, and biological activity.

Drug discovery bottlenecks - Support the design of novel glycopeptide therapeutics, including antibiotics, vaccines, and targeted drug candidates.

Analytical limitations - Provide advanced characterization methods to accurately confirm glycopeptide structures and purity, reducing experimental uncertainty.

Customization needs - Address unique project requirements for glycan type, peptide length, linkage strategy, and labeling.

Our Glycopeptide Service Capabilities

We provide end-to-end glycopeptide synthesis and analysis solutions that combine advanced chemical and enzymatic strategies with state-of-the-art analytical technologies. Each project is customized to meet your specific research or development goals, whether in drug discovery, vaccine development, or structural biology. Below is a detailed overview of our service offerings:

01

Custom Glycopeptide Synthesis

  • Site-Specific Glycosylation - We design and synthesize peptides with precisely controlled glycan attachment sites (e.g., N-linked, O-linked, or non-natural linkages).
  • Diverse Glycan Repertoire - Access to a wide variety of N-glycans, O-glycans, sialylated structures, fucosylated motifs, and synthetic analogs.
  • Scalable Production - From milligram-scale for research use to gram-scale batches for preclinical studies.
02

Synthetic O-Linked Glycopeptides

  • Site-specific incorporation of O-linked glycans such as Core 1-8, mucin-type glycans, and customized O-glycan motifs.
  • Chemical and chemoenzymatic methods for precise glycan attachment at serine or threonine residues.
  • Applications in mucin biology, cancer immunology, and vaccine design.
03

Synthetic N-Linked Glycopeptides

  • Synthesis of N-linked glycopeptides with high-mannose, hybrid, or complex-type glycans.
  • Accurate glycosylation at asparagine residues following the consensus N-X-S/T motif.
  • Essential for studying protein folding, stability, and therapeutic glycoprotein models.
04

Semi-Synthetic and Enzymatic Approaches

  • Chemoenzymatic Strategies - Integration of chemical peptide synthesis with glycosyltransferases or glycosidases for efficient and natural-like glycosylation.
  • Fragment Assembly - Use of native chemical ligation (NCL) and solid-phase peptide synthesis (SPPS) to construct complex glycopeptides.
  • Improved Yield & Fidelity - Optimized workflows to ensure higher efficiency and reproducibility compared with purely chemical synthesis.
05

Comprehensive Analytical Characterization

  • Mass Spectrometry (LC-MS/MS, MALDI-TOF) for exact mass confirmation and glycan pattern analysis.
  • HPLC & UPLC Profiling to assess purity, glycan heterogeneity, and product consistency.
  • NMR Spectroscopy for in-depth structural elucidation of glycopeptide conformations.
  • Bioassays & Binding Studies to evaluate biological activity, receptor interaction, or immunogenicity.
06

Structure and Sequence Optimization

  • Peptide Engineering - Rational design of peptide backbones to enhance glycan accessibility, solubility, and biological performance.
  • Stability Enhancement - Strategies such as pegylation, unnatural amino acids, or modified linkers to improve half-life and bioavailability.
  • Glycan Selection Guidance - Support in choosing the most suitable glycan motifs for desired biological outcomes.
07

Rigorous Quality Assurance

  • GLP-compliant Workflows - Standardized processes ensuring reliability and reproducibility.
  • Batch-to-Batch Consistency - Advanced QC monitoring for long-term projects and collaborations.
  • Documentation & Reporting - Detailed technical reports with synthesis conditions, analytical data, and performance outcomes.

Why Choose Our Glycopeptide Services?

Our platform stands out because of its scientific expertise, technical innovation, and client-focused approach:

Expert Team in Glycoconjugate Chemistry: Specialists with extensive experience in glycopeptide and glycoconjugate synthesis for both academic and pharmaceutical applications.

Cutting-Edge Technology & Methods: Access to advanced chemoenzymatic synthesis, solid-phase peptide synthesis (SPPS), and native chemical ligation (NCL) to tackle even the most complex glycopeptides.

Customization & Flexibility: Tailored services to meet diverse needs: from milligram-scale exploratory projects to gram-scale preclinical requirements.

Comprehensive Analytical Support: End-to-end verification using LC-MS/MS, HPLC, NMR, and bioassays to ensure accuracy, reliability, and publication-quality data.

High Purity & Reproducibility: Strict QC and validated protocols guarantee consistent, high-quality results.

Confidentiality & IP Protection: All projects are handled under strict confidentiality agreements to safeguard your intellectual property.

Global Client Support: Efficient communication, flexible timelines, and dedicated technical assistance for clients worldwide.

Applications of Glycopeptide Services

Our glycopeptide synthesis and analysis services are widely used across multiple disciplines. Below are the key application areas with specific examples:

Drug Discovery & Development

  • Novel Therapeutics - Design and synthesis of glycopeptides as candidates for antibiotics, antivirals, and oncology drugs.
  • SAR Studies - Structure-activity relationship analysis to evaluate how glycosylation impacts stability, binding affinity, and bioavailability.
  • Lead Optimization - Support in modifying peptide backbones and glycan motifs to enhance therapeutic performance.

Vaccine Research & Immunology

  • Epitope Mapping - Use of glycopeptides to identify glycan-dependent epitopes recognized by antibodies.
  • Immunogenicity Testing - Evaluation of glycopeptides as immunogens or adjuvants in preclinical vaccine studies.
  • Pathogen Interaction Models - Simulation of host-pathogen interactions involving glycosylated peptides.

Glycobiology & Structural Biology

  • Protein Folding Studies - Glycopeptides as models to investigate glycan effects on secondary and tertiary structures.
  • Molecular Recognition - Analysis of glycan-protein interactions relevant to signaling pathways and receptor binding.
  • Conformational Analysis - Structural validation through NMR, X-ray crystallography, or computational modeling.

Biomarker Discovery & Diagnostics

  • Cancer Biomarkers - Development of glycopeptide probes for detecting tumor-associated glycosylation patterns.
  • Infectious Disease Markers - Design of glycopeptides mimicking viral or bacterial glyco-epitopes for diagnostic assays.
  • Autoimmune Disease Research - Identification of abnormal glycopeptide modifications linked to immune disorders.

Material & Chemical Biology

  • Surface Functionalization - Use of glycopeptides for modifying biomaterials, nanoparticles, or biosensors.
  • Nanotechnology - Development of glycopeptide-based nanostructures for targeted delivery or imaging.
  • Chemical Biology Tools - Creation of probes to study glycan-dependent biological pathways.

Our Glycopeptide Service Workflow

To ensure efficiency, transparency, and reliable results, we follow a well-defined project workflow:

Requirement Assessment and Project Planning

1Project Consultation & Requirement Analysis

Initial discussion to understand your research goals, peptide sequences, desired glycan structures, and expected outcomes.

Confidential evaluation of feasibility, project scope, and technical specifications.

Requirement Assessment and Project Planning

2Design & Proposal

Custom design of synthesis strategy, including choice of glycans, peptide backbone, and conjugation method.

Delivery of a detailed project plan with timeline, cost estimate, and milestones.

Requirement Assessment and Project Planning

3Glycopeptide Synthesis

Execution of chemical, semi-synthetic, or chemoenzymatic synthesis methods.

Controlled production with strict process monitoring to ensure reproducibility.

Requirement Assessment and Project Planning

4Purification & Characterization

High-purity isolation using HPLC/UPLC.

Comprehensive structural verification by LC-MS/MS, MALDI-TOF, and NMR.

Requirement Assessment and Project Planning

5Quality Control & Validation

Rigorous QC tests for purity, glycosylation site accuracy, and biological activity if required.

Batch-to-batch comparison for consistent results.

Requirement Assessment and Project Planning

6Delivery & Technical Support

Delivery of glycopeptide samples with a full analytical report.

Ongoing support for troubleshooting, data interpretation, and follow-up experiments.

Frequently Asked Questions (FAQs)

1. Can I request specific glycans or linkages?

Yes. We offer a wide variety of N-linked, O-linked, and custom synthetic glycans, with site-specific conjugation strategies tailored to your requirements.

We provide flexible scales, from milligram quantities for academic research to gram-level batches suitable for preclinical testing.

Absolutely. Every project is delivered with a comprehensive analytical report including LC-MS/MS, HPLC, and, if applicable, NMR data.

Yes. Our scientists provide consultative support on peptide sequence design, glycan selection, and structural optimization.

Ready to Start Your Glycopeptide Project?

Partner with us to accelerate your research and development with high-quality custom glycopeptide synthesis. Our expert team not only delivers fully characterized glycopeptides, but also offers a wide selection of glycans ready for direct conjugation, including:

By combining flexible glycan libraries with state-of-the-art peptide synthesis platforms, we provide end-to-end solutions that save time, reduce cost, and ensure reproducibility.

Contact us today to discuss your project requirements and receive a customized proposal. Together, we can bring your glycopeptide research to the next level.

* Only for research. Not suitable for any diagnostic or therapeutic use.
Send Inquiry
Verification code