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O-Glycan Synthesis Services

At BOC Sciences, we provide professional O-glycan synthesis services that deliver structurally defined, high-purity glycans tailored to your research and development needs. With expertise in custom design, glycan libraries, isotope labeling, and conjugation, our team ensures precise control over glycan structures that cannot be achieved through natural extraction. By integrating state-of-the-art glycoengineering platforms and advanced analytical validation (MS, NMR, HPLC), we support applications ranging from biomedical research and diagnostics to biopharma and vaccine development. Whether you require standard core O-glycans or complex customized structures at research or preclinical scale, we provide reliable solutions that accelerate discovery and innovation.

What Problems We Solve?

O-glycans are key components of many glycoproteins and function in various physiological processes, including protein folding and quality control, cell signaling, immune modulation and disease progression. The diverse and complex nature of O-glycans makes it challenging to isolate from natural sources with sufficient yield and homogeneity. Our customized O-glycan synthesis service can address many common issues, including:

Natural complexity - isolation from natural sources often has many impurities and batch-to-batch variations

Structural control - difficulty in obtaining desired structures for more targeted glycan chain designs, tailored for specific biological or therapeutic functions

Speed - isolation from natural sources is often time consuming; our approach allows you to quickly access defined O-glycans

Scalability - we can scale up the synthesis of defined glycans from milligram level for research use to gram scale for preclinical use

Outsourcing O-glycan synthesis to us provides an accessible route to high purity and well-defined O-glycans that are well characterized and ready to accelerate your discoveries.

Our O-Glycan Synthesis Services

We provide end-to-end O-glycan synthesis solutions with flexible options to match your research and development goals. Each service is designed to ensure high quality, reproducibility, and scientific impact:

01

Custom O-Glycan Design & Synthesis

We design and synthesize O-glycans with precise structures tailored to your scientific needs.

  • Define monosaccharide sequences, branching, and linkages with exact control.
  • Access both simple core glycans and complex extended chains.
  • Ensure reproducibility and high purity beyond what natural extraction can offer.
02

Isotope-Labeled O-Glycans

We supply isotope-labeled O-glycans for advanced glycomics and metabolic research.

  • Provide stable isotope tracers for accurate metabolic pathway analysis.
  • Enable quantitative glycomics with enhanced MS-based sensitivity.
  • Support detailed structural and functional studies with labeled glycans.
03

O-Glycan Conjugation

We specialize in conjugating O-glycans to biomolecules and nanomaterials.

  • Conjugate glycans to proteins, peptides, lipids, and nanoparticles.
  • Enable applications in vaccine design, diagnostics, and therapeutics.
  • Guarantee controlled linkage chemistry for reliable biofunctionality.
04

Analytical Characterization

We ensure every glycan is validated with rigorous analytical techniques.

  • Confirm identity and structure using mass spectrometry (MS).
  • Assess purity and homogeneity via HPLC profiling.
  • Provide NMR structural analysis with full documentation.
05

Flexible Scale-Up Options

We adapt synthesis from small batches to larger production runs.

  • Deliver milligram-scale samples for early-stage experiments.
  • Offer gram-scale production for preclinical or industrial applications.
  • Maintain consistent quality across all production scales.

Why Choose Our O-Glycan Synthesis Services?

We go beyond standard synthesis by offering unique advantages that accelerate your success:

Expertise in Glycoscience: Backed by a team of glycoengineering specialists, we provide solutions that combine deep scientific knowledge with practical application.

Tailored to Your Needs: Every synthesis project is customized-whether you need simple core O-glycans, extended glycan chains, or functional glycoconjugates.

High Purity & Reproducibility: Our synthesis and QC processes guarantee consistent, high-quality O-glycans, minimizing batch-to-batch variability.

Comprehensive Capabilities: From custom design, glycan libraries, isotope labeling, to large-scale production, we cover the entire spectrum of glycan research needs.

Accelerated Timelines: Optimized synthesis pathways ensure fast turnaround without compromising quality-ideal for time-sensitive research and preclinical studies.

Global Support: We serve clients worldwide with reliable logistics, ensuring safe and timely delivery of O-glycans across different regions.

Application of O-Glycan Synthesis

O-glycans are fundamental to many biological processes and have become an essential focus in glycobiology, biopharma, and diagnostic research. Our O-glycan synthesis services provide reliable access to high-quality glycans that accelerate innovation across multiple fields.

Biomedical Research

Synthetic O-glycans enable scientists to study fundamental biological mechanisms.

  • Investigate cell signaling pathways and receptor interactions.
  • Explore glycosylation changes in cancer, autoimmune, and infectious diseases.
  • Provide model glycans for functional studies in glycobiology.

Biopharmaceutical Development

O-glycans are essential for optimizing therapeutic proteins and biologics.

  • Improve stability, solubility, and half-life of glycoprotein drugs.
  • Support glycoengineered antibody development with controlled glycan patterns.
  • Facilitate preclinical studies with reproducible synthetic glycans.

Vaccine Design and Development

Well-defined O-glycans contribute to next-generation immunotherapies and vaccines.

  • Create glycan-peptide conjugates for vaccine candidates.
  • Enhance antigen presentation and immune recognition.
  • Enable targeted cancer and infectious disease vaccine research.

Diagnostic Biomarker Discovery

Aberrant O-glycosylation provides valuable markers for diagnostics.

  • Supply specific glycan epitopes for assay development.
  • Support ELISA and microarray platforms with synthetic glycans.
  • Facilitate biomarker validation studies with reproducible standards.

Drug Delivery and Nanomedicine

O-glycan conjugates improve precision in therapeutic delivery systems.

  • Functionalize liposomes and nanoparticles with glycans for targeting.
  • Enhance bioavailability and stability of drug carriers.
  • Enable glycan-mediated tissue or receptor-specific delivery.

High-Throughput Screening & Glycan Arrays

Synthetic glycan libraries accelerate discovery in glycobiology and drug design.

  • Construct custom glycan arrays for protein–glycan interaction studies.
  • Enable high-throughput screening of lectins, antibodies, and receptors.
  • Identify novel therapeutic and diagnostic targets using defined O-glycans.

Our Service Workflow for O-Glycan Synthesis

We follow a transparent and efficient workflow to ensure every O-glycan synthesis project is delivered with precision and reliability:

Requirement Assessment and Project Planning

1Consultation & Project Evaluation

We begin with an in-depth discussion of your scientific goals, desired glycan structures, and application requirements.

Our experts provide technical guidance and feasibility assessment to align the project with your needs.

Requirement Assessment and Project Planning

2Custom Design & Strategy Planning

Based on your specifications, we design the most effective synthetic route.

This includes choosing optimal building blocks, linkages, and protective group strategies to ensure high yield and purity.

Requirement Assessment and Project Planning

3O-Glycan Synthesis & Conjugation

Our experienced chemists perform synthesis using advanced glycoengineering platforms.

If required, conjugation to proteins, peptides, or nanoparticles is carried out under strict quality control.

Requirement Assessment and Project Planning

4Analytical Validation

Every product is rigorously characterized with MS, NMR, and HPLC to confirm structure, purity, and stability.

Detailed analytical reports are delivered along with your O-glycan samples.

Requirement Assessment and Project Planning

5Delivery & Ongoing Support

Final products are shipped securely with documentation.

Our team offers post-delivery support, ensuring smooth integration into your research or product development pipeline.

Frequently Asked Questions (FAQs)

1. What is O-Glycan synthesis and why is it important?

O-glycan synthesis is the artificial preparation of O-linked glycans, which are complex carbohydrate structures attached to proteins via serine or threonine residues. They play critical roles in cell signaling, immune response, and disease mechanisms. Custom synthesis ensures structural precision and reproducibility that natural extraction cannot guarantee.

Yes. We provide core O-glycan structures as well as extended, branched, and modified glycans. Our expertise allows us to meet diverse requirements, from basic research glycans to advanced conjugates for therapeutic applications.

Absolutely. We maintain a selection of pre-synthesized O-glycans that can be directly conjugated to proteins, peptides, or nanoparticles. This option saves time for researchers who need fast access to functional glycans.

All synthesized glycans undergo rigorous quality control and structural validation using techniques such as mass spectrometry (MS), nuclear magnetic resonance (NMR), and high-performance liquid chromatography (HPLC). Clients receive full analytical reports with every order.

We can deliver from milligram quantities for exploratory studies to gram-scale production for preclinical research. Our scale-up process ensures consistent quality at every stage.

Yes. We specialize in glycan conjugation to proteins, peptides, lipids, nanoparticles, and microarrays. This is highly valuable for vaccine development, drug delivery, and biomarker discovery.

Yes. We ship worldwide with secure packaging and temperature control when necessary, ensuring glycans arrive safely and ready for immediate use.

Get Started with Custom O-Glycan Synthesis

Ready to accelerate your glycoscience research? At BOC Sciences, we not only offer fully customized O-glycan synthesis, but also maintain a portfolio of readily available glycans (including common core O-glycan structures, extended chains, and modified variants) that can be directly conjugated to proteins, peptides, lipids, or nanoparticles upon request.

Whether you require rapid access to standard glycans for preliminary studies, or tailor-made conjugates for advanced applications, our team ensures fast turnaround, analytical validation, and secure delivery worldwide.

Contact us today to request a quote and discover how our O-glycan synthesis services can empower your next breakthrough in biomedical research, biopharma, and diagnostics.

* Only for research. Not suitable for any diagnostic or therapeutic use.
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