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Glycoprotein Synthesis Service

Our glycoprotein services form part of our comprehensive glycoconjugate synthesis platform. We are well-versed in the complex field of glycobiology and chemical biology, and our expert team can assist research laboratories and biotech companies with the design, synthesis, characterisation and functional study of glycoproteins. We have experience supporting projects for basic research, therapeutic development and diagnostic applications, and can help deliver high-quality results to speed up your research and commercial timelines.

What Problems Do Our Glycoprotein Services Solve?

Complexity of Glycosylation: Natural glycoproteins are structurally diverse, making them difficult to produce and analyze. We provide tailored strategies to simplify and control glycosylation patterns.

Reproducibility Issues: Standard protein expression systems often yield inconsistent glycan structures. Our optimized methods ensure reliable and consistent production.

Functional Characterization: Understanding glycan-protein interactions is critical for drug development and biomarker research. Our service offers robust analytical workflows to clarify these mechanisms.

Scalability Challenges: Transitioning from small-scale synthesis to larger production can be costly and technically demanding. We support seamless scaling to fit research and preclinical needs.

Our Glycoprotein Service Capabilities

01

Custom Glycoprotein Synthesis

We design and produce glycoproteins with precisely controlled glycan structures to meet diverse research and development needs.

  • Tailored Design: Synthesis of glycoproteins mimicking natural forms or introducing novel glycans.
  • Flexible Platforms: Combination of biological expression systems and chemical synthesis.
  • Application-Driven: Suitable for vaccine antigens, therapeutic proteins, and biomarker studies.
02

Site-Specific Glycosylation Engineering

We offer precise modification of glycosylation sites to study structure–function relationships and enhance protein performance.

  • Targeted Attachment: Controlled addition of glycans at specific amino acid residues.
  • Functional Impact: Investigation of effects on protein stability, folding, and activity.
  • Therapeutic Optimization: Engineering glycoproteins for improved efficacy and reduced immunogenicity.
03

Comprehensive Analytical Characterization

We provide a full suite of glycoprotein analysis services to ensure accurate profiling and validation. Our capabilities include:

  • Mass spectrometry (MS) for glycan structure determination and site mapping.
  • High-performance liquid chromatography (HPLC) for separation and quantification of glycoforms.
  • Glycan mapping and sequencing for detailed structural insights.
  • Biophysical and functional assays to assess activity, binding affinity, and stability.

These techniques deliver a complete picture of glycoprotein quality and function, ensuring reproducibility and reliability in research and product development.

04

Enzymatic and Chemoenzymatic Approaches

We employ cutting-edge enzymatic and chemoenzymatic methods for efficient and accurate glycoprotein assembly.

  • Enzymatic Precision: Use of glycosyltransferases and glycosidases for specific modifications.
  • Chemoenzymatic Synthesis: Hybrid strategies to build rare or complex glycans.
  • High Efficiency: Streamlined workflows ensuring reproducibility and scalability.
05

Application-Focused Solutions

Our services are designed with end-use applications in mind:

  • Therapeutic protein development: Optimization of glycosylation for better stability, reduced immunogenicity, and enhanced efficacy.
  • Vaccine design: Production of glycoproteins with antigenic glycans for improved immune responses.
  • Biomarker discovery: Identification and synthesis of glycoproteins relevant to disease diagnostics.
  • Fundamental research: Support for structural biology and glycobiology studies requiring pure, well-characterized glycoproteins.

Advantages of Our Glycoprotein Services

Choosing our glycoprotein services under the umbrella of glycoconjugate synthesis offers distinct advantages:

Expertise in Glycobiology and Chemistry: A team with years of experience in glycoscience, ensuring accuracy in design, synthesis, and characterization.

Customizable Solutions: Flexible service options tailored to specific applications in therapeutics, vaccines, and biomarker discovery.

Cutting-Edge Technology: Use of state-of-the-art enzymatic and chemoenzymatic platforms for precise glycosylation control.

High Quality & Reproducibility: Rigorous analytical validation guarantees consistent results across batches.

Scalable Production: From small-scale exploratory studies to larger preclinical projects, we adapt to meet your needs efficiently.

Confidential and Reliable Service: Full protection of intellectual property and strict quality control throughout the workflow.

Application Areas of Glycoprotein Services

Biopharmaceutical Development

  • Monoclonal Antibody Optimization: Control of Fc glycosylation to improve antibody-dependent cellular cytotoxicity (ADCC) and half-life.
  • Therapeutic Protein Stability: Tailored glycosylation to enhance solubility, folding, and in vivo performance.
  • Biosimilar & Biobetter Support: Comparative glycoprotein profiling for biosimilar development and next-generation biologics.

Vaccine Research and Design

  • Antigen Mimicry: Production of glycoprotein antigens resembling viral or bacterial glycan epitopes for improved immune recognition.
  • Immune Response Enhancement: Glycoengineering to modulate immunogenicity and boost vaccine efficacy.
  • Glycan-Based Adjuvants: Development of glycoprotein conjugates that act as novel adjuvant systems.

Biomarker Discovery & Diagnostics

  • Cancer Biomarkers: Identification and synthesis of tumor-associated glycoproteins such as altered mucins or glycan antigens.
  • Infectious Disease Markers: Production of pathogen-specific glycoproteins for diagnostic assay development.
  • Glycoprotein Arrays: High-throughput screening platforms to profile disease-related glycan patterns.

Structural and Functional Glycobiology

  • Protein Folding Studies: Use of glycoproteins with defined glycans to investigate folding pathways and stability.
  • Receptor Binding Analysis: Mapping glycan-receptor interactions to understand cell signaling and pathogen entry.
  • Structure-Function Relationships: Engineering glycoproteins to study how glycosylation impacts biological activity.

Enzyme Engineering & Synthetic Biology

  • Glycoenzyme Design: Creation of glycoprotein-based enzymes with enhanced catalytic properties.
  • Synthetic Pathway Integration: Incorporation of engineered glycoproteins into synthetic biology circuits.
  • Novel Biocatalyst Development: Production of unique glycoproteins as tools for glycan assembly and modification.

Our Glycoprotein Service Workflow

We follow a clear and efficient workflow to ensure high-quality and reliable glycoprotein solutions:

Requirement Assessment and Project Planning

1Consultation & Project Design

We begin with in-depth discussions to understand your project requirements, whether for research, therapeutic development, or diagnostic applications. Our experts design a customized glycoprotein strategy tailored to your scientific and commercial goals.

Requirement Assessment and Project Planning

2Sample Preparation & Expression

Depending on the project scope, we use optimized biological expression systems or synthetic methods to generate the target protein backbone. This step ensures scalability and consistency from milligram to gram levels.

Requirement Assessment and Project Planning

3Glycosylation Engineering

Using advanced enzymatic and chemoenzymatic approaches, we introduce precise glycan structures, including natural, modified, or rare glycans, at specific sites. This process ensures accuracy and reproducibility.

Requirement Assessment and Project Planning

4Analytical Characterization

Each glycoprotein undergoes comprehensive analysis, including mass spectrometry, HPLC, glycan mapping, and functional assays, to confirm structure, purity, and biological activity.

Requirement Assessment and Project Planning

5Final Delivery & Technical Support

Clients receive fully characterized glycoproteins along with detailed analytical reports. We also provide ongoing technical support to help integrate the results into your research or development pipeline.

Frequently Asked Questions (FAQs)

1. What types of glycoproteins can you produce?

We can synthesize a broad range of glycoproteins, including therapeutic candidates, vaccine antigens, enzymes, and customized research-grade glycoproteins with defined glycan structures.

We use optimized expression systems and advanced glycoengineering techniques, followed by rigorous analytical validation (MS, HPLC, glycan mapping) to guarantee consistent quality.

Yes. We provide site-specific glycosylation engineering using chemoenzymatic and enzymatic approaches, enabling precise control over glycan attachment and structure.

Our services range from milligram-scale for exploratory research to gram-scale production suitable for preclinical studies.

Absolutely. Each project includes a comprehensive report with detailed characterization data, ensuring full transparency and traceability.

Partner with Us for Advanced Glycoprotein Solutions

Ready to accelerate your research and development with reliable glycoprotein services? Our team combines expertise in glycoconjugate synthesis, glycoengineering, and analytical characterization to deliver tailor-made solutions for therapeutics, vaccines, and biomarker discovery.

In addition to full custom glycoprotein synthesis, we also provide a library of well-defined glycans - such as sialylated glycans, fucosylated glycans, high-mannose glycans, and hybrid N-glycans - that can be directly conjugated to proteins, peptides, or other biomolecules. This ensures flexibility and efficiency for clients who require specific glycan structures without starting from scratch.

Contact us today to discuss your project needs and discover how our glycoprotein services can support your scientific breakthroughs.

* Only for research. Not suitable for any diagnostic or therapeutic use.
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