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Oct. 27-28, 2025, Boston, MA, USA - Booth 114.
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Generate Glycan Profile Service

Generate Glycan Profile service is a specialized service that helps researchers and biotechnology companies to gain accurate, reproducible, and publication-quality glycosylation data with high confidence. Combining state-of-art technologies and approaches, such as high-resolution mass spectrometry, HPLC and bioinformatics-guided data analysis, we can provide detailed information of N-glycans as well as O-glycans including identification, structural elucidation, and quantitation. Whether you are working on biopharmaceutical development, disease-associated glycans, or biomarker discovery, we can provide you with the glycan profiling data you need to power research, enhance product quality and meet regulatory compliance.

What Problems Does Generate Glycan Profiling Solve?

Complexity of Glycosylation: Glycans are highly diverse and structurally complex, making them difficult to analyze without specialized tools.

Biological Significance: Aberrant glycosylation is linked to diseases such as cancer, autoimmune disorders, and viral infections. Profiling helps identify biomarkers and therapeutic targets.

Biopharmaceutical Development: Inconsistent glycosylation can impact drug safety, efficacy, and regulatory approval. Profiling ensures quality control and compliance.

Research Bottlenecks: Without precise glycan data, research outcomes risk being incomplete or misleading. Profiling provides the clarity needed for robust scientific conclusions.

Our Specific Generate Glycan Profiling Services

01

Separation Techniques

We use high-resolution separation methods to isolate glycans and ensure clean, distinct profiles for analysis.

  • HPLC (UV, RID, DAD, ELSD): Sensitive detection of diverse glycan species with multiple detector options.
  • UHPLC (DAD, RID): Ultra-high performance liquid chromatography for improved speed and resolution.
  • Ion Chromatography (PAD): High specificity for charged carbohydrate species.
  • Gas Chromatography (Direct & Head Space): Suitable for volatile derivatives and advanced structural studies.
  • TLC & Gel Electrophoresis: Complementary methods for rapid glycan separation and visualization.
02

Characterisation Methods

We perform structural elucidation of glycans using state-of-the-art spectroscopic and spectrometric tools.

  • NMR (1H, 13C, 19F, 31P, COSY, HMBC, DEPT, DEPT135, DEPTQ, HMQC): In-depth molecular structure determination.
  • Mass Spectrometry (MS, MS/MS, ESI-TOF, MALDI-TOF): High sensitivity for glycan sequencing, fragmentation, and profiling.
  • FTIR: Functional group analysis to confirm structural features.
  • UV Spectroscopy: Detection of chromophore-labeled glycans and confirmation of sample purity.
03

Elemental & Microanalysis

To guarantee sample integrity and compliance, we provide detailed elemental and micro-level testing.

  • Karl-Fischer Titration: Accurate determination of water content in glycan samples.
  • Titrations: Quantitative analysis of functional groups for chemical consistency.
  • Residue on Ignition: Assessment of inorganic impurities after combustion.
  • Loss on Drying: Determination of volatile matter and sample stability.
04

Physical Chemistry Analysis

We assess physicochemical properties to provide a complete glycan profile.

  • Melting Point Determination: Establishing purity and thermal stability of glycan derivatives.
  • Polarimetry: Measuring optical rotation to confirm stereochemistry and molecular identity.
05

Data Interpretation and Reporting

We go beyond raw data to provide actionable insights from glycan profiles.

  • Detailed annotation of glycan structures, linkages, and modifications.
  • Biological relevance analysis for disease research or biopharma.
  • Publication-ready figures, clear datasets, and expert commentary.

Why Choose Our Generate Glycan Profiling Services?

Advanced Technology: High-resolution HPLC, MS/MS, and NMR platforms optimized for glycan analysis.

Glycan Expertise: Specialists in glycobiology and biopharmaceutical glycosylation studies.

Custom Profiling: Flexible workflows for N-glycans, O-glycans, and complex glycoconjugates.

Validated Accuracy: Reproducible results meeting international research and regulatory standards.

Actionable Reports: Clear glycan profiles with structural annotation and biological relevance.

Application Areas of Generate Glycan Profiling

Biopharmaceutical Development

  • Ensure glycan consistency in monoclonal antibodies and therapeutic proteins.
  • Support regulatory submissions with detailed glycosylation profiles.
  • Detect structural variants that impact drug safety and efficacy.

Disease Research & Biomarker Discovery

  • Identify glycan alterations linked to cancer, autoimmune, and infectious diseases.
  • Discover glycan-based biomarkers for diagnostics and prognostics.

Vaccine & Immunology Studies

  • Analyze glycan patterns in viral glycoproteins and vaccine antigens.
  • Monitor immune response influenced by glycosylation changes.
  • Support vaccine design with glycan-specific structural data.

Food & Nutrition Sciences

  • Profile oligosaccharides in milk, plant, and microbial sources.
  • Assess functional glycans linked to gut microbiome health.
  • Support nutraceutical product development with glycan characterization.

Fundamental Glycoscience

  • Explore glycan diversity across species and biological systems.
  • Investigate structure–function relationships of complex glycans.
  • Provide reference data for academic publications and databases.

Step-by-Step Workflow for Our Services

Our Generate Glycan Profile service follows a streamlined and transparent workflow to ensure accuracy, efficiency, and reliability:

Requirement Assessment and Project Planning

1Consultation & Project Design

Understand client needs and research objectives.

Define project scope, target molecules, and analytical requirements.

Provide customized experimental plan and timeline.

Requirement Assessment and Project Planning

2Sample Preparation & Quality Check

Perform standardized sample handling to preserve glycan integrity.

Conduct pre-analysis QC to ensure sample suitability.

Apply optimized protocols for glycan release and derivatization.

Requirement Assessment and Project Planning

3Analytical Profiling

Execute separation and characterization using advanced techniques (HPLC, MS, NMR, etc.).

Apply validated methods tailored to N-glycans and O-glycans.

Ensure reproducibility with strict internal standards.

Requirement Assessment and Project Planning

4Data Analysis & Interpretation

Process raw data with specialized bioinformatics pipelines.

Identify glycan structures, quantify abundance, and detect modifications.

Provide comparative analysis where applicable.

Requirement Assessment and Project Planning

5Reporting & Delivery

Deliver a comprehensive report with publication-ready figures.

Highlight key findings, trends, and potential biological implications.

Offer post-report consultation to support further research or regulatory submission.

Frequently Asked Questions (FAQs)

1. What sample types can be analyzed?

We can analyze glycans from proteins, glycoproteins, cells, tissues, serum, vaccines, and biopharmaceutical products.

We deliver both raw data and processed reports, including publication-ready figures and expert interpretation.

Absolutely. We offer tailored workflows to match specific research or industrial needs.

Ready to Generate Your Glycan Profile?

Unlock the power of glycan profiling to accelerate your research and product development. Our service delivers accurate N-glycan and O-glycan profiles using advanced analytical platforms, providing reliable data for biopharmaceutical development, disease biomarker discovery, and nutritional science.

We specialize in generating profiles for a wide range of glycans, including:

Contact us today to start your glycan profiling project and receive a customized analysis plan.

* Only for research. Not suitable for any diagnostic or therapeutic use.
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