We offer comprehensive glycan modification and functionalization services to support cutting-edge research, biopharmaceutical development, and diagnostic innovation. By combining enzymatic glycoengineering with advanced chemical strategies, our team delivers highly customized glycans with improved stability, bioactivity, and conjugation potential. Whether you need reducing-end modifications, surface functionalization, or PEGylated glycans for therapeutic use, we provide precise, reproducible solutions tailored to your scientific and industrial goals—backed by rigorous analytical validation and scalable production capabilities.
Limited glycan diversity: Native glycans often lack the structural variations required for advanced biological studies or therapeutic applications.
Low functional performance: Unmodified glycans may not provide the desired binding, stability, or bioactivity in drug discovery and biomaterials.
Complex workflows: Glycan functionalization requires specialized knowledge, equipment, and reproducible methodologies, which can be difficult to access in-house.
Integration hurdles: Researchers and companies often struggle to efficiently integrate custom glycans into their existing platforms for vaccines, antibodies, or biosensors.
We provide tailored enzymatic and chemical strategies to generate glycans with specific structures for advanced applications.
We design covalent conjugation methods to attach glycans to biomolecules, nanoparticles, or solid supports.
We enhance glycan properties to maximize performance in therapeutic, diagnostic, and research settings.
We verify structural accuracy and functional integrity using state-of-the-art analytical techniques.
We provide customized strategies designed for your unique research or industrial application.
We excel in chemical approaches for reducing-end and functional modifications, enabling precise control over glycan reactivity and functional diversity. Each service is designed to expand glycan applications across biotechnology, pharmaceuticals, and advanced materials.
We functionalize the reducing-end of glycans for easy conjugation with biomolecules and surfaces.
We selectively introduce sulfate or acetyl groups to modulate glycan charge and functionality.
We add phosphate groups to glycans to enhance reactivity and biological mimicry.
We introduce carboxyl groups to generate glycans with reactive carboxylic handles.
We add thiol (-SH) groups to enable site-specific conjugation with maleimide-functionalized molecules.
We attach polyethylene glycol (PEG) chains to glycans to improve biocompatibility and circulation.
We create NHS-ester glycans for rapid, stable coupling with primary amines.
We prepare maleimide-functionalized glycans for selective thiol reactivity.
We introduce amino groups to glycans, providing versatile reactive sites.
Our glycan modification and functionalization services combine chemical methods, enzymatic reactions, and bioengineering approaches to deliver precise and versatile solutions.
We perform modifications at the reducing-end of glycans or on specific functional groups, allowing precise structural tailoring.
We leverage glycosyltransferases and other glycan-related enzymes to achieve highly specific modifications.
We apply metabolic and genetic engineering strategies to control glycan biosynthesis pathways.
Partnering with us means gaining access to unique expertise and industry-leading capabilities:
Comprehensive Expertise: Strong background in glycan chemistry, combining both enzymatic and chemical modification strategies.
Custom Solutions: Every project is designed to meet specific client needs, ensuring modifications that fit both research and industrial applications.
High Precision & Reproducibility: Rigorous quality control ensures consistent, accurate modifications that are publication- and production-ready.
Cutting-Edge Instrumentation: Equipped with advanced analytical platforms (HPLC, MS, NMR) for reliable structural verification.
Scalability: Capable of delivering modifications at research scale or pre-clinical development scale, with flexible production capacity.
Fast Turnaround Time: Optimized workflows ensure efficient project execution without compromising quality.
Confidentiality & IP Protection: Strict data security and confidentiality policies safeguard your proprietary research and intellectual property.
Our glycan modification and functionalization services support a wide range of scientific and industrial applications:
We follow a streamlined, client-focused workflow to ensure accuracy, reproducibility, and efficiency in every glycan modification project:
We begin with an in-depth discussion to understand your research goals, application requirements, and target specifications. Our experts design a tailored modification strategy to fit your project.
Based on your needs, we prepare a detailed proposal outlining the recommended modification techniques-enzymatic, chemical, or hybrid approaches-and timelines.
Our team carries out the modification under strict quality control using advanced instrumentation and validated protocols.
We perform thorough structural and functional characterization (HPLC, MS, NMR) to confirm the accuracy of each modification.
Clients receive a comprehensive report including methodology, analytical results, and recommendations for downstream applications. Modified glycans are delivered in the requested format for immediate use.
We provide post-delivery technical support to help integrate the modified glycans into your workflows, whether for research, therapeutic development, or diagnostics.
We work with a wide variety of glycans, including N-glycans, O-glycans, glycolipids, polysaccharides, and synthetic glycan analogs. We also provide pre-functionalized glycans ready for conjugation.
Yes. We offer enzymatic glycoengineering for precision biological structures, as well as chemical methods such as PEGylation, sulfation, phosphorylation, and reducing-end modifications.
Absolutely. Every project is tailored to client needs. We can develop modification strategies specific to your application, whether research-scale or pre-clinical development.
All modifications undergo strict quality control and analytical verification using HPLC, MS, and NMR, ensuring accuracy and reproducibility.
Yes. We supply detailed experimental reports, analytical data, and recommendations to support regulatory filings and scientific publications.
Yes. We provide scalable solutions, from milligram-level research projects to larger-scale modifications suitable for pre-clinical or pilot studies.
Whether you need custom glycan modifications, specialized chemical functionalization, or ready-to-use glycans for direct conjugation, we are here to accelerate your project. Our team combines deep expertise with cutting-edge technology to deliver solutions tailored to your research and development needs.
We also provide a selection of pre-modified glycans that can be directly conjugated to proteins, peptides, nanoparticles, or biomaterials-saving you valuable time and ensuring reliable performance in downstream applications.
Contact us today to discuss your project, request a quote, or learn more about our catalog of functional glycans. Let us help you transform complex glycan chemistry into powerful research and therapeutic solutions.
