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N-Glycan Synthesis Services

We offer a bespoke N-Glycan synthesis service for use in your research or biopharmaceutical projects. Utilizing synthetic chemistry, enzymatic strategies, and our analytical capabilities, we can provide pure and well-defined N-Glycans for a wide range of applications. This can include use in glycomics or structural studies requiring defined glycans, standards for analytical assays, or glycoconjugates for applications in therapeutic research. Our service is dependable, accurate, and scalable.

What Problems Can N-Glycan Synthesis Solve?

Research Challenges: Naturally derived glycans are often heterogeneous and difficult to isolate in pure form. Our synthesis service provides structurally defined N-Glycans for reproducible research outcomes.

Drug Development Needs: N-Glycans play critical roles in protein folding, stability, and immunogenicity. Customized glycans help pharmaceutical teams better understand drug–glycan interactions and optimize biologics.

Analytical Standards: Access to high-purity synthetic N-Glycans ensures accurate method validation in glycoproteomics, LC-MS, HPLC, and other analytical platforms.

Structure-Function Studies: Synthetic glycans enable researchers to precisely investigate glycan-protein interactions, immune responses, and disease mechanisms.

Our N-Glycan Synthesis Services

01

Custom N-Glycan Design

We provide tailor-made N-Glycan structures designed to meet your specific research or industrial needs.

  • Rare Motif Synthesis - Creation of uncommon branching or linkage patterns not available commercially.
  • Tailored Modifications - Incorporation of sialylation, fucosylation, or sulfation as requested.
  • Application-Oriented Design - Structures optimized for biologics, glycomics, or diagnostic research.
02

Enzymatic & Chemoenzymatic Synthesis

We combine chemical synthesis with enzymatic reactions to efficiently generate complex glycans.

  • Precise Linkage Control - Use of glycosyltransferases ensures accurate glycan branching.
  • Higher Yield - Chemoenzymatic strategies improve production efficiency.
  • Complex Structures - Capable of producing multi-antennary and highly branched N-Glycans.
03

Isotopically Labeled N-Glycans

We provide stable isotope-labeled glycans for advanced glycomics and quantitative studies.

  • LC-MS/MS Standards - Improve accuracy in mass spectrometry quantification.
  • Structural Elucidation - Aid in detailed analysis of glycan linkages and branching.
  • Reproducible Results - Provide consistent internal standards across experiments.

We conjugate synthetic glycans to biomolecules or materials for functional applications.

  • Protein & Peptide Conjugation - Creation of glycopeptides and glycoproteins for therapeutic use.
  • Nanoparticle Functionalization - Enhance drug delivery or imaging platforms with glycan coatings.
  • Vaccine Development - Conjugated glycans used to design glyco-vaccines targeting specific pathogens.
05

Comprehensive Analytical Characterization

Every synthesized glycan is validated with rigorous analytical methods to guarantee quality. This ensures clients receive accurate, reproducible, and publication-ready glycans.

  • HPLC Purity Testing - Ensures high-purity glycans suitable for sensitive applications.
  • LC-MS/MS Structural Confirmation - Provides accurate glycan profiling and identification.
  • NMR Analysis - Offers detailed insight into glycan linkage and stereochemistry.

Why Choose Our N-Glycan Synthesis Services?

Choosing us as your partner gives you clear advantages:

Expertise in Glycobiology & Chemistry - Our team combines deep knowledge of glycoscience with advanced synthetic chemistry and enzymology.

Customized Solutions - From rare glycan motifs to complex multi-branched structures, we tailor synthesis to your exact needs.

High Purity & Reproducibility - Every product undergoes stringent analytical characterization, ensuring consistent quality for sensitive experiments.

Scalable Production - We support projects from small research quantities to larger-scale synthesis for industrial applications.

Fast Turnaround - Optimized workflows allow us to deliver results in shorter timelines without compromising quality.

Comprehensive Support - Beyond synthesis, we provide consultation, data interpretation, and integration advice for your glycomics projects.

Applications of N-Glycan Synthesis

Our N-Glycan synthesis services are crucial for advancing research and product development across multiple fields. Here are some of the key applications:

Biopharmaceutical Development

  • Protein Stability & Folding - Synthetic N-Glycans help evaluate how glycosylation influences protein folding, stability, and half-life in therapeutic proteins.
  • Optimizing Monoclonal Antibodies (mAbs) - Defined glycans are used to control Fc glycosylation patterns, improving antibody-dependent cellular cytotoxicity (ADCC).
  • Reducing Immunogenicity - Customized glycosylation reduces unwanted immune responses, improving drug safety profiles.

Glycomics Research

  • Analytical Standards - High-purity N-Glycans serve as reliable reference materials for LC-MS and HPLC.
  • Structural Mapping - Used to decode glycan structures on glycoproteins for precise glycoproteomic studies.
  • Interaction Studies - Enable systematic evaluation of glycan–protein or glycan–lectin binding mechanisms.

Drug Discovery & Development

  • High-Throughput Screening - Synthetic glycans are applied in screening assays to identify new drug-glycan interactions.
  • Lead Optimization - Aid in refining glycosylated drug candidates for enhanced pharmacokinetics.
  • Target Identification - Help uncover glycan-related disease targets for novel therapeutic strategies.

Vaccine Development

  • Glycan-Conjugated Antigens - Synthetic N-Glycans are conjugated to proteins to mimic pathogen surfaces.
  • Immune Modulation - Certain glycan structures enhance immune recognition and boost vaccine efficacy.
  • Pathogen Mimicry - Replicating natural glycan epitopes supports rational vaccine design against viruses and bacteria.

Diagnostics & Biomarker Discovery

  • Glycan Microarrays - Synthetic glycans are used to identify disease-specific binding partners.
  • Cancer Biomarkers - Support the detection of abnormal glycosylation patterns linked to tumor progression.
  • Infectious Disease Assays - Aid in developing diagnostic tools that target pathogen-specific glycans.

Glycobiology and Cell Biology Studies

  • Cell Signaling - Defined glycans are used to dissect how glycosylation regulates receptor-ligand interactions.
  • Immune Recognition - Help study how immune cells recognize specific glycan structures.
  • Disease Mechanisms - Provide tools for understanding roles of glycans in cancer, autoimmunity, and viral infection.

Our Service Workflow for N-Glycan Synthesis

To ensure efficiency, transparency, and scientific rigor, we follow a clear step-by-step workflow for each N-Glycan synthesis project:

Requirement Assessment and Project Planning

1Project Consultation & Design

We begin with a detailed discussion of your research goals, glycan specifications, and intended applications.

Our experts propose the most suitable synthesis strategy (chemical, enzymatic, or chemoenzymatic).

Requirement Assessment and Project Planning

2Feasibility Assessment & Proposal

We evaluate the technical feasibility, expected timelines, and cost.

A customized proposal is shared for your approval.

Requirement Assessment and Project Planning

3Synthesis & Optimization

Our team executes the synthesis using optimized methods for high yield and structural accuracy.

Parallel optimization is applied if multiple glycan structures are requested.

Requirement Assessment and Project Planning

4Purification & Quality Control

Synthesized glycans are purified using HPLC and validated through advanced analytical techniques (LC-MS, NMR).

Each batch is delivered with a full QC report for reproducibility and reliability.

Requirement Assessment and Project Planning

5Delivery & Technical Support

Final products are shipped in the required format and quantity.

We provide ongoing technical support, ensuring smooth integration into your research or product development.

Frequently Asked Questions (FAQs)

1. What types of N-Glycans can you synthesize?

We can provide high-mannose, hybrid, and complex-type N-Glycans, as well as custom-designed structures with specific branching, linkages, or modifications. Both natural analogs and rare glycan motifs can be synthesized according to your project requirements.

We employ a combination of chemical synthesis, enzymatic synthesis, and chemoenzymatic strategies. This allows us to produce highly defined and complex glycans with excellent purity and structural accuracy.

All products undergo rigorous analytical characterization including HPLC, LC-MS/MS, and NMR. A full QC (Quality Control) report is provided with each order to ensure reproducibility and data reliability.

Yes. We offer a selection of ready-to-use glycans that can be directly conjugated to proteins, peptides, lipids, or nanoparticles. This is particularly useful for applications in vaccine development, glycan-protein interaction studies, and drug delivery systems.

We can deliver from milligram-scale glycans for research purposes to larger-scale synthesis suitable for industrial or pre-clinical applications.

Absolutely. Our team offers comprehensive technical support including guidance on conjugation, analytical use, and data interpretation, ensuring smooth integration into your research workflow.

Ready to Accelerate Your Glycan Research?

Our custom N-Glycan synthesis services are designed to meet the highest research and industrial standards. In addition to tailored synthesis, we also provide ready-to-use glycans such as high-mannose, hybrid, and complex-type N-Glycans that can be directly conjugated to proteins, peptides, lipids, or nanoparticles. This gives you an immediate advantage in applications like vaccine development, drug delivery systems, glycan-protein interaction studies, and diagnostic assay design.

Contact us today to discuss your project needs and get a customized solution. Our team of glycoscience experts is ready to help you move from idea to results-faster, with precision, and with the highest confidence in data quality.

* Only for research. Not suitable for any diagnostic or therapeutic use.
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