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Neoglycoprotein Synthesis Service

We provide professional Neoglycoprotein synthesis services as part of our comprehensive Glycoconjugate Synthesis platform. With cutting-edge expertise in carbohydrate chemistry and protein conjugation, our team delivers tailor-made solutions to generate high-quality neoglycoproteins for research, diagnostics, and therapeutic development. By combining precise glycan design with reliable protein modification strategies, we help you unlock the biological potential of glycoconjugates with accuracy and efficiency.

Problems We Solve

Developing neoglycoproteins is often a major challenge due to the complexity of glycan-protein interactions, difficulties in achieving site-specific conjugation, and the need for reproducibility at scale. Our service addresses these obstacles by:

Overcoming the limitations of natural glycosylation with custom-designed glycan structures.

Enabling consistent and controlled conjugation to proteins or peptides.

Supporting applications in vaccine design, biomarker discovery, drug development, and glycan-binding studies.

Providing scalable, reproducible methods that reduce time and technical barriers in laboratory research.

Our Neoglycoprotein Synthesis Services

Our services are designed to cover the full workflow from concept to validated product. Below is a breakdown of what we can deliver:

01

Custom Neoglycoprotein Design & Synthesis

We deliver tailor-made neoglycoproteins with specific glycan structures optimized for your research goals.

  • Flexible glycan selection: Choose from monosaccharides, disaccharides, oligosaccharides, or custom-designed glycans.
  • Protein compatibility: Conjugation with peptides, recombinant proteins, or antibodies to suit diverse projects.
  • Application-focused synthesis: Designs optimized for vaccines, immunology, diagnostics, or receptor studies.
02

Site-Specific & Controlled Conjugation

We apply advanced chemistries to ensure precise and reproducible glycan attachment.

  • Reductive amination, oxime ligation, click chemistry: Multiple methods for reliable conjugation.
  • Orientation control: Minimizes structural heterogeneity and preserves biological activity.
  • Scalable reproducibility: Consistent results across pilot and larger production batches.
03

Analytical Characterization & Quality Validation

To guarantee the structural integrity and functionality of your neoglycoproteins, we provide comprehensive quality control and analytical validation, including:

  • Mass spectrometry (MS) for molecular weight and conjugation confirmation.
  • High-performance liquid chromatography (HPLC) for purity profiling.
  • Nuclear Magnetic Resonance (NMR) for structural characterization.
  • Binding assays and functional testing to evaluate biological activity.
04

Scale-Up & Production Support

We provide scalable synthesis for both small research projects and preclinical development.

  • Pilot-scale synthesis: Ideal for exploratory studies and proof-of-concept work.
  • Larger-batch production: Supports preclinical testing, assay development, or industrial use.
  • Batch-to-batch consistency: Reliable protocols ensure reproducibility at all scales.
05

Application-Oriented Consultation

We go beyond synthesis to support the scientific success of your project. Our experts work closely with you to:

  • Identify the most suitable glycans for your research goals.
  • Optimize conjugation strategies for improved bioavailability and stability.
  • Suggest applications in vaccine design, glycan-array construction, immunology studies, and diagnostic assay development.

Why Choose Our Neoglycoprotein Services?

Expertise in Glycobiology & Chemistry: Our team combines deep domain knowledge with hands-on experience in carbohydrate-protein conjugation.

High Customization: From glycan structure to conjugation chemistry, every project is tailored to meet your exact scientific or industrial needs.

Reliable Reproducibility: Optimized protocols and strict quality control guarantee batch-to-batch consistency and dependable results.

Advanced Analytical Support: Comprehensive validation ensures structural accuracy and functional activity, reducing uncertainty in your research outcomes.

Scalability from Research to Preclinical: Whether you need milligram-level samples for exploratory studies or larger-scale synthesis for development, we can support your workflow seamlessly.

End-to-End Scientific Partnership: Beyond delivering neoglycoproteins, we provide strategic insights into their applications in vaccine development, diagnostics, immunology, and therapeutic research.

Application Areas of Neoglycoprotein Services

Our Neoglycoprotein synthesis services support a wide range of applications in biotechnology, life sciences, and pharmaceutical research. Below are the major fields and their specific uses:

Vaccine Development

  • Glycoconjugate vaccines: Neoglycoproteins act as immunogens by coupling bacterial or viral carbohydrate antigens to carrier proteins, enhancing immune recognition.
  • Improved immunogenicity: Custom-designed glycans boost the immune response compared with free polysaccharides or native glycoproteins.
  • Preclinical research: Reliable neoglycoproteins provide consistent tools for evaluating vaccine efficacy and safety.

Diagnostics & Biomarker Discovery

  • Assay development: Neoglycoproteins are used to detect glycan-binding proteins, antibodies, or pathogens with high sensitivity.
  • Biomarker identification: Specific glycan-protein conjugates help in discovering disease-associated glycan markers.
  • Point-of-care diagnostics: Stable neoglycoproteins enable rapid test kit development for field applications.

Drug Development & Screening

  • Receptor binding studies: Neoglycoproteins mimic natural glycoproteins, enabling accurate screening of drug-receptor interactions.
  • Therapeutic evaluation: They serve as models for testing drug efficacy, especially for anti-glycan therapeutics.
  • High-throughput screening: Ready-to-use conjugates accelerate compound screening pipelines in pharma research.

Immunology & Glycan-Protein Interaction Studies

  • Immune recognition: Neoglycoproteins allow detailed study of how glycans influence immune cell activation and signaling.
  • Pathogen-host interactions: They help unravel the role of glycan receptors in bacterial, viral, and parasitic infections.
  • Autoimmune disease research: Defined glycan conjugates are used to investigate abnormal immune responses to glycans.

Glycan Microarrays & Biosensor Development

  • Array construction: Neoglycoproteins can be immobilized on microarray platforms for high-throughput glycan-binding studies.
  • Biosensor integration: They serve as recognition elements in glycan-based biosensors for diagnostics and environmental monitoring.
  • Quantitative binding analysis: Arrays of neoglycoproteins provide measurable data on binding affinities and kinetics.

Basic Glycobiology Research

  • Structure-function analysis: Neoglycoproteins provide simplified models to study how glycans affect protein structure and function.
  • Enzyme activity assays: They are used as substrates or probes for glycosyltransferases and glycosidases.
  • Fundamental glycobiology: Custom glycoconjugates support research into the biological roles of glycans in health and disease.

Our Neoglycoprotein Synthesis Workflow

Requirement Assessment and Project Planning

1Project Consultation & Design

Requirement Assessment and Project Planning

2Custom Glycan & Protein Preparation

Requirement Assessment and Project Planning

3Conjugation & Synthesis

Requirement Assessment and Project Planning

4Analytical Characterization

Requirement Assessment and Project Planning

5Delivery & Technical Support

Frequently Asked Questions (FAQs)

1. What is a neoglycoprotein?

A neoglycoprotein is a synthetic glycoconjugate created by attaching defined glycans to proteins or peptides through chemical conjugation, enabling controlled studies of glycan-protein interactions.

Unlike natural glycoproteins, which often exhibit heterogeneous and unpredictable glycosylation, neoglycoproteins allow precise glycan design and site-specific conjugation, ensuring reproducibility and functional accuracy.

We can synthesize and conjugate a wide range of glycans, including mono-, di-, and oligosaccharides, as well as custom-designed structures tailored to your project.

Yes. Our service supports both small-scale research needs and larger-scale production suitable for preclinical research and industrial applications.

Each product undergoes rigorous analytical characterization (MS, HPLC, NMR, binding assays) to confirm glycan incorporation, conjugation efficiency, purity, and biological activity.

Yes. Our team of experts offers end-to-end consultation, helping you select suitable glycans, conjugation chemistries, and project strategies.

Ready to Start Your Neoglycoprotein Project?

Unlock the full potential of glycoconjugate research with our professional Neoglycoprotein synthesis services. Whether you are exploring glycan-protein interactions, developing vaccines, or building diagnostic assays, our expert team is here to support you from design to delivery.

We also maintain a collection of ready-to-use glycans that can be directly conjugated to proteins, saving you valuable time and accelerating project timelines. These include, but are not limited to:

By offering custom and standard glycans for conjugation, we ensure flexibility and efficiency tailored to your research or industrial needs.

Contact us today to discuss your project requirements and discover how our Neoglycoprotein expertise can accelerate your success.

* Only for research. Not suitable for any diagnostic or therapeutic use.
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