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Glycoconjugate Synthesis Service

We specialize in providing custom glycoconjugate synthesis services, offering a full spectrum of solutions from glycoproteins, glycolipids, glycopeptides, and neoglycoconjugates to ADC glycosylation, glycan-drug conjugates, biotinylated glycans, and fluorescently labeled glycans. Leveraging cutting-edge synthetic chemistry and enzymatic techniques, we deliver high-purity, structurally defined glycoconjugates that meet the needs of vaccine development, drug discovery, diagnostic assay design, and fundamental glycobiology research. With expertise spanning design, synthesis, characterization, and scale-up production, our services provide researchers and biotech innovators with reliable, reproducible, and publication-ready glycans, accelerating the path from concept to breakthrough application.

Challenges We Help You Overcome

Complexity of carbohydrate chemistry: Glycans are structurally diverse and challenging to synthesize, requiring specialized expertise and optimized protocols.

Reproducibility issues: Traditional synthesis routes often produce inconsistent yields and purity, slowing down R&D progress.

Customization needs: Many research and therapeutic applications require tailor-made glycoconjugates with exacting specifications.

Time and cost constraints: In-house synthesis can be resource-intensive, delaying critical experiments and development timelines.

By outsourcing glycoconjugate synthesis to us, you eliminate these barriers and gain reliable, expert-driven support.

Key Glycoconjugate Synthesis Services We Offer

We synthesize glycolipids and neoglycolipids with controlled structures for research in vaccines and membrane biology.

  • Provide natural and synthetic glycolipids for studying immune responses.
  • Supply neoglycolipids as probes for carbohydrate–lipid recognition.
  • Support lipid-based antigen development for vaccines and diagnostics.

We create native-like and engineered glycoproteins to advance structural biology and therapeutic development.

  • Attach defined glycans to proteins for structure-function analysis.
  • Generate neoglycoproteins for epitope mapping and immunogenicity testing.
  • Support biologic drug development with controlled glycosylation patterns.

We design and synthesize site-specific glycopeptides for targeted biological research and drug delivery.

  • Create glycopeptides with controlled glycan attachment sites.
  • Support studies on antigen presentation and immune recognition.
  • Provide custom glycopeptides for peptide-based therapeutic development.

We enable precise glycosylation strategies for antibody-drug conjugates (ADCs).

  • Engineer glycosylation sites for enhanced targeting and stability.
  • Improve pharmacokinetics through controlled glycan modifications.
  • Support development of next-generation ADC therapeutics.

We design glycan-drug conjugates to improve therapeutic delivery and efficacy.

  • Link glycans to small molecules for targeted drug delivery.
  • Develop conjugates to enhance drug solubility and bioavailability.
  • Support novel glycan-based drug candidate pipelines.

We provide biotin-labeled glycans for use in detection, affinity studies, and immobilization assays.

  • Facilitate protein-glycan binding studies via streptavidin systems.
  • Enable high-sensitivity glycan detection in biological samples.
  • Support biosensor development and microarray technologies.

We produce fluorescently tagged glycans to support imaging and interaction analysis.

  • Enable real-time cell imaging of glycan-receptor interactions.
  • Provide labeled glycans for flow cytometry and high-throughput screening.
  • Support glycan tracking in drug delivery and cell biology research.
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Oligosaccharide and Polysaccharide Synthesis

We deliver well-defined oligosaccharides and polysaccharides with excellent purity for reliable biological research.

  • Provide custom oligosaccharides for receptor-binding studies.
  • Synthesize polysaccharides for vaccine and therapeutic development.
  • Ensure high reproducibility with advanced synthetic methodologies.
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Advanced Structural Analysis

We perform comprehensive analytical validation to ensure product integrity and reproducibility.

  • Use NMR and MS for detailed structural confirmation.
  • Apply HPLC and LC-MS for purity and identity analysis.
  • Deliver complete QC reports for regulatory or publication purposes.
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Flexible Production Scale

We adapt our synthesis to your needs, from research-scale to preclinical supply.

  • Provide milligram-scale batches for early discovery research.
  • Deliver gram-scale quantities for preclinical applications.
  • Offer scalable workflows to accelerate translational research.
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Expert Consulting

We offer consultation services to guide your project from design to application.

  • Advise on glycan selection and conjugation strategy.
  • Support experimental design for maximum impact.
  • Collaborate closely to ensure scientific and technical success.

Why Choose Our Glycoconjugate Synthesis Services?

Expertise in Complex Glycochemistry: A team of scientists with deep expertise in carbohydrate chemistry, glycan engineering, and bioconjugation.

Comprehensive Service Portfolio: Covering glycolipids, neoglycoproteins, glycopeptides, ADC glycosylation, drug conjugates, glycan labeling, and more.

High-Quality Standards: Rigorous analytical characterization ensures reproducibility and regulatory compliance.

Customization & Flexibility: Tailor-made solutions designed for vaccines, therapeutics, diagnostics, and academic research.

Scalable Production Capacity: From small discovery batches to preclinical-scale synthesis, matching your project's growth.

Collaborative Approach: Direct communication with our scientific team, ensuring transparency and continuous support.

Faster Turnaround & Cost-Effective Solutions: Optimized protocols reduce synthesis time and costs, helping you accelerate research timelines.

Applications of Glycoconjugate Synthesis

Our glycoconjugate synthesis services are widely applied across life sciences, pharmaceuticals, and biotechnology. Common application areas include:

Vaccine Development

Glycoconjugates play a critical role in creating safe and effective vaccines.

  • Conjugation of bacterial or viral polysaccharides to carrier proteins to boost immunogenicity.
  • Development of carbohydrate-based antigens for cancer and infectious disease vaccines.
  • Use of glycolipids and neoglycoproteins as innovative vaccine adjuvants.

Drug Discovery & Therapeutics

Tailored glycoconjugates accelerate drug development and improve therapeutic performance.

  • Design of glycan-drug conjugates to enhance solubility, stability, and bioavailability.
  • Site-specific glycosylation of antibodies (ADCs) for targeted cancer therapies.
  • Creation of glycopeptides and glycoproteins as novel therapeutic candidates.

Diagnostics & Biomarker Research

Engineered glycans enable highly sensitive and specific diagnostic tools.

  • Biotinylated glycans for microarray and affinity-based biomarker detection.
  • Fluorescently labeled glycans for real-time imaging and flow cytometry.
  • Defined oligosaccharides as probes for disease-related biomarker discovery.

Immunology & Glycobiology Studies

Custom glycoconjugates help decode complex immune responses and glycan functions.

  • Synthesis of glycopeptides and glycoproteins to study antigen recognition.
  • Neoglycolipids and neoglycoproteins as probes for receptor binding research.
  • Defined glycan libraries to map carbohydrate-protein interactions.

Structural Biology & Biophysical Analysis

Synthetic glycans are essential for understanding molecular mechanisms at the structural level.

  • Use of oligosaccharides in crystallography and NMR studies of glycan-protein complexes.
  • Polysaccharides for studying conformational changes and binding affinities.
  • Fluorescent or isotope-labeled glycans for tracking molecular interactions.

Biotechnology & Synthetic Biology

Glycoconjugates expand possibilities in engineering biomolecules and biosystems.

  • Development of glycan-modified biosensors for analytical applications.
  • Engineering glycoconjugates for cell-based assays and biopharmaceutical innovation.
  • Integration of glycans into synthetic biology platforms for novel therapeutics and materials.

Step-by-Step Workflow for Our Glycoconjugate Synthesis

Requirement Assessment and Project Planning

1Design & Strategy

We start by understanding your project requirements and research objectives, then propose optimal glycan structures and conjugation chemistries. Our design stage includes feasibility analysis and project planning for maximum efficiency.

Requirement Assessment and Project Planning

2Synthesis & Conjugation

We perform custom synthesis of glycoconjugates using state-of-the-art chemistries, including reductive amination, click chemistry, and enzymatic glycosylation. Targets include protein carriers, peptides, lipids, nanoparticles, and other biomolecules.

Requirement Assessment and Project Planning

3Characterization & Validation

All synthesized glycoconjugates are characterized with advanced techniques such as NMR, MALDI-TOF MS, LC-MS, and HPLC. This ensures structural accuracy, batch-to-batch reproducibility, and compliance with publication or regulatory standards.

Requirement Assessment and Project Planning

4Scale-Up Support

From small-scale discovery batches to gram-level preclinical supplies, we provide flexible scale-up pathways. Our optimized protocols reduce costs and shorten timelines.

Requirement Assessment and Project Planning

5Collaborative Expertise

Beyond synthesis, we offer one-on-one scientific support. Our team can advise on glycan selection, biological testing strategies, and long-term project planning, making us not just a service provider but a research partner.

Frequently Asked Questions (FAQs)

1. What is glycoconjugate synthesis?

Glycoconjugate synthesis refers to the process of chemically or enzymatically attaching carbohydrates (glycans) to biomolecules such as proteins, peptides, lipids, or drugs. This creates functional glycoconjugates used in vaccines, therapeutics, diagnostics, and research.

Typically, we require your target molecule details, desired glycan structure, intended application (e.g., vaccine, diagnostic, drug development), and preferred scale. Our team will then propose the optimal conjugation strategy.

We offer flexible production, from milligram-scale samples for research to gram-scale synthesis suitable for preclinical studies.

Each glycoconjugate undergoes comprehensive analytical validation, including NMR, MS, and HPLC, ensuring structural accuracy, purity, and reproducibility.

Yes. Our strength lies in tailor-made solutions. We can design, synthesize, and validate novel glycoconjugates according to your project's needs.

Absolutely. Beyond synthesis, our experts provide consultation for biological assays, project design, and long-term research planning.

Ready to Advance Your Research?

Partner with us to accelerate your discovery with reliable, high-quality glycoconjugate synthesis services. Whether you are developing vaccines, designing novel therapeutics, or conducting fundamental glycobiology research, our expert team is here to provide end-to-end support- from custom design to analytical validation and scale-up production.

We also maintain a curated library of ready-to-conjugate glycans, including:

Contact us today to discuss your project and explore how our glycoconjugate synthesis expertise and ready-to-use glycan portfolio can accelerate your path to breakthrough results.

* Only for research. Not suitable for any diagnostic or therapeutic use.
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