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Ginsenoside Rc
Ginsenoside Rc Chemical Structure

Ginsenoside Rc

Catalog NO.: B0005-465149 CAS NO.: 11021-14-0 Brand: BOC Sciences

Category
Carbohydrates, Nucleosides & Nucleotides
Application/Structure
Oligosaccharides Glycosides
Molecular Formula
C53H90O22
Molecular Weight
1079.30
Size Price Stock Quantity
20 mg $199 In stock

Request another packsize? Click Bulk Order.

cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
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Product Description

Ginsenoside Rc is a steroid glycoside, which is found exclusively in the plant genus Panax (ginseng). It has properties that inhibit or prevent tumors growth. It may have effects that prevent or limit the development of breast cancer.

Quantity
Milligrams-Grams
InChI Key
JDCPEKQWFDWQLI-LUQKBWBOSA-N
InChI
InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-68-45-41(65)36(60)28(21-56)69-45)24-11-16-52(7)33(24)25(57)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)35(59)27(20-55)71-48)74-46-42(66)38(62)34(58)26(19-54)7
SMILES
CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)OC7C(C(C(C(O7)COC8C(C(C(O8)CO)O)O)O)O)O)C
Write a review Ask a question

I would appreciate it if you could answer my questions. How Ginsenoside Rc ameliorates endothelial insulin resistance.

You're welcome! Ginsenoside Rc ameliorates endothelial insulin resistance via upregulation of angiotensin-converting enzyme 2.

12/6/2019

Dear sir, how does Ginsenoside Rc attenuates DSS-induced ulcerative colitis, intestinal inflammatory, and barrier function in mice?

Howdy! Ginsenoside Rc attenuates DSS-induced ulcerative colitis, intestinal inflammatory, and barrier function in mice by activating the farnesoid X receptor.

28/8/2022

Hi, and how does Ginsenoside Rc ameliorate atherosclerosis in mice?

Hello, Ginsenoside Rc ameliorated atherosclerosis in mice via regulating gut microbiota and fecal metabolites.

9/12/2022

recover the abnormal levels of inflammation indexes

It's very useful for our project! Ginsenoside Rc can significantly recover the abnormal levels of inflammation indexes (TNF-α, IL-6, IL-1β, and NF-KB) induced by LPS in LS174T in my lab.

12/6/2016

alleviate Acetaminophen-induced cellular apoptosis

Ginsenoside Rc worked perfectly in mouse primary hepatocytes (MPHs). Ginsenoside Rc effectively alleviates Acetaminophen-induced cellular apoptosis and NAPQI accumulation in MPHs.

9/11/2017

correct the imbalance of vasomotor factors

In our research, Ginsenoside Rc do well in correcting the imbalance of vasomotor factors, reducing the production of Ang (angiotensin) II, and activating angiotensin-converting enzyme 2 (ACE2)/Ang-(1-7)/Mas axis in HG-treated HUVECs.

21/10/2022

1.Screening SIRT1 Activators from Medicinal Plants as Bioactive Compounds against Oxidative Damage in Mitochondrial Function.
Wang Y1, Liang X1, Chen Y1, Zhao X2. Oxid Med Cell Longev. 2016;2016:4206392. doi: 10.1155/2016/4206392. Epub 2016 Feb 11.
Sirtuin type 1 (SIRT1) belongs to the family of NAD(+) dependent histone deacetylases and plays a critical role in cellular metabolism and response to oxidative stress. Traditional Chinese medicines (TCMs), as an important part of natural products, have been reported to exert protective effect against oxidative stress in mitochondria. In this study, we screened SIRT1 activators from TCMs and investigated their activities against mitochondrial damage. 19 activators were found in total by in vitro SIRT1 activity assay. Among those active compounds, four compounds, ginsenoside Rb2, ginsenoside F1, ginsenoside Rc, and schisandrin A, were further studied to validate the SIRT1-activation effects by liquid chromatography-mass spectrometry and confirm their activities against oxidative damage in H9c2 cardiomyocytes exposed to tert-butyl hydroperoxide (t-BHP). The results showed that those compounds enhanced the deacetylated activity of SIRT1, increased ATP content, and inhibited intracellular ROS formation as well as regulating the activity of Mn-SOD.
2.[Progress of the regulation effect of ginsenosides on HPA axis].
Li H, Liu SY, Wang B. Yao Xue Xue Bao. 2014 May;49(5):569-75.
Ginseng is a typical adaptogen which has resistance to various stresses. This effect is related to the hypothalamic-pituitary-adrenal (HPA) axis. As the main active ingredients, saponin has the similar structure to steroids. The regulation characteristics of ginseng saponin on the HPA axis are narrated from the aspects of total saponin and saponin monomers in this paper after the introduction of adaptation definition and HPA axis regulation mechanisms. Pharmacological effects of ginseng saponin and the regulation effect of HPA axis are summarized finally.
3.Quantitation of eleven active compounds of Aidi injection in rat plasma and its application to comparative pharmacokinetic study.
Liu R1, Ma R2, Yu C1, Bi CW3, Yin Y1, Xu H1, Shang H1, Bi K1, Li Q4. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 3. pii: S1570-0232(15)30126-4. doi: 10.1016/j.jchromb.2015.07.059. [Epub ahead of print]
Aidi injection has been widely used for the treatment of colorectal cancer. The purpose of this study was to develop a sensitive and reliable method for simultaneous quantitation of 11 main active ingredients in Aidi injection and to compare the pharmacokinetics of these ingredients in normal and colorectal model cancer rats after tail vein injection. After being extracted by isopropanol-ethyl acetate (1:1, v/v), the plasma samples were analyzed with domperidone as internal standard. Then the analytes were separated on a Venusil MP C18 column with 0.15% formic acid and methanol. The detection was performed on HPLC-MS/MS system with turbo ion spray source in the positive ion and multiple reaction-monitoring mode. The assay was shown to be linear over the range of 0.004-4.0μgmL-1 of syringin B, astragaloside II and isofraxidin; 0.01-10.0μgmL-1 of calycosin-7-O-β-d-glucoside and astragaloside IV; 0.02-20.0μgmL-1 of ginsenoside Rg1, Rb1, Rc and Rd; 0.
4.Ginsenoside Rc from Korean Red Ginseng (Panax ginseng C.A. Meyer) Attenuates Inflammatory Symptoms of Gastritis, Hepatitis and Arthritis.
Yu T1,2, Rhee MH3, Lee J4, Kim SH5, Yang Y1,2, Kim HG1, Kim Y1, Kim C6, Kwak YS7, Kim JH8, Cho JY1. Am J Chin Med. 2016 Apr 24:1-21. [Epub ahead of print]
Korean Red Ginseng (KRG) is an herbal medicine prescribed worldwide that is prepared from Panax ginseng C.A. Meyer (Araliaceae). Out of ginseng's various components, ginsenosides are regarded as the major ingredients, exhibiting anticancer and anti-inflammatory activities. Although recent studies have focused on understanding the anti-inflammatory activities of KRG, compounds that are major anti-inflammatory components, precisely how these can suppress various inflammatory processes has not been fully elucidated yet. In this study, we aimed to identify inhibitory saponins, to evaluate the in vivo efficacy of the saponins, and to understand the inhibitory mechanisms. To do this, we employed in vitro lipopolysaccharide-treated macrophages and in vivo inflammatory mouse conditions, such as collagen (type II)-induced arthritis (CIA), EtOH/HCl-induced gastritis, and lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-triggered hepatitis. Molecular mechanisms were also verified by real-time PCR, immunoblotting analysis, and reporter gene assays.
Preparing Stock Solutions
ConcentrationVolumeMass1 mg5 mg10 mg
1 mM0.9266 mL4.6328 mL9.2655 mL
5 mM0.1853 mL0.9266 mL1.8531 mL
10 mM0.0927 mL0.4633 mL0.9266 mL
50 mM0.0185 mL0.0927 mL0.1853 mL
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