Microbial Fermentation Services

Microbial fermentation refers to the use of microorganisms, under suitable conditions, the raw materials through a specific metabolic pathway into the products needed by human beings. The production level of microbial fermentation mainly depends on the genetic characteristics and culture conditions of the strain itself. According to the requirements of fermentation conditions, microbial fermentation process can be divided into aerobic fermentation and anaerobic fermentation. Aerobic fermentation methods include liquid surface culture fermentation, porous or granular solid medium surface fermentation and aerobic submerged fermentation. The submerged fermentation with no oxygen was used in the anaerobic fermentation. Therefore, both aerobic and anaerobic fermentation can be realized by deep culture, which is completed in a cylindrical fermentor with a certain ratio of diameter to height.

Microbial Fermentation Services

Application of Microbial Fermentation

Fermentation engineering has the characteristics of mild production conditions, rich sources of raw materials and low price, specific products, low environmental pollution and easy disposal of waste. It has been widely used in pharmaceutical industry, food industry, agriculture, metallurgy industry, environmental protection and many other fields, and gradually formed a large-scale fermentation industry. As far as the application of fermentation engineering in pharmaceutical industry is concerned, it has achieved remarkable results, such as antibiotics, vitamins, animal hormones, medicinal amino acids, nucleotides (such as inosine) and so on. At present, there are more than 100 kinds of antibiotics, such as penicillins, cephalosporins, erythromycin and tetracyclines. In addition, a large number of genetic engineering drugs produced by fermentation engineering, such as human growth hormone, recombinant hepatitis B vaccine, some kinds of monoclonal antibodies, IL-2, anti-hemophilia factor and so on.

Our Microbial Fermentation Offering Includes:

  • Complex small molecule (Metabolites, carbohydrates, impurities, Enzymes Biotransformation products)
  • Downstream processing
  • Bacteria, yeast, Filamentous Fungi, Mammalian

Our Advantages

  • Fermentation facilities include fermentor of all sizes, from laboratory scale (1 liter and 15 litres) to pilot scale (150L) and pre-industrial scale (1.500 litres), Equipped with temperature, pH value, oxygen dioxide, air, pressure, stirring control and regulations.
  • Downstream equipment includes centrifuges, microfilters, ultrafilters, reverse osmosis devices, filter dryers and bell filters. Chromatographic tests can be carried out on a laboratory scale.
  • With a good knowledge of the advanced techniques, flexible production volume, systematic quality and EHS management, we are your first choice to access global supply chain and one-stop procurement.
  • Equipped with 22 fermentation production lines including various sizes of fermenters with total fermentation volume of 12000 m3 and flexible methods for extraction and purification, we are able to prepare products in various categories.
  • Our chemical and microbiological laboratories provide analytical support for the quality control of raw materials and final products.

The integrated fermentation and purification development of BOC Sciences, as well as the analysis and development team, work together to achieve the highest quality of the plan while maintaining flexibility to meet the needs of the plan.

References

  1. Singh, V., San Yeoh, B., Chassaing, B., Xiao, X., Saha, P., Olvera, R. A., ... & Flythe, M. D. (2018). Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer. Cell, 175(3), 679-694.
  2. Quinn, R. A., Whiteson, K., Lim, Y. W., Salamon, P., Bailey, B., Mienardi, S., ... & Rohwer, F. (2015). A Winogradsky-based culture system shows an association between microbial fermentation and cystic fibrosis exacerbation. The ISME journal, 9(4), 1024.