Lab Testing Services

Lab testing services, just as its name implies, including some routine chemical and physical analytical measures, is quick and convenient. Nowadays, state-of-the-art technologies and instrumentation along with close collaboration with synthetic organic chemists ensure the highest quality project execution. We solve the most difficult problems by asking the right questions and using the right tools. Our lab testing services range from identifying an impurity in a manufacturing process, degradation products during storage or characterization of a reference standard-all the way to a full Physical & Chemical Characterization Study for a range of salt forms or polymorphs. BOC Sciences’ analytical development group supports projects in an integrated services motif, and ensures that the most progress is made in a timely and cost-effective manner.

Below is a list of our available analytical Services (include but not limited to the following):

  • Structure elucidation service: deciphering the structure of complex compounds 
  • Physical & Chemical Characterization: extracting intrinsic properties from the chemicals provided
  • Chiral resolution: getting a single chiral enantiomer that is beneficial to the human body and the environment.
  • Identity confirmation: getting purity and structure information
  • Analytical lab testing:measure the properties of materials and the fundamental performance of components
  • Impurity profiling: identifying impurities or degradation products

Below is a list of our available analytical techniques (include but not limited to the following):

  • Nuclear Magnetic Resonance (NMR)

Nuclear Magnetic Resonance is especially important in the structure analysis of organic compounds. Our Bruker 500 MHz, 400 MHz and 300 MHz Ultra-shield solution state spectrometers are capable of detecting 1H, 13C, 19F and 31P nuclei and are also capable of performing a suite of two-dimensional techniques for the structural elucidation/confirmation of your compounds. Due to the direct correlation between the number of nuclei present and peak areas, qNMR could be used for the quantitation of organic compounds, as for assay determination of the material, quantification of impurities and solvents and analysis of enantiomers/stereoisomers ratios.

  • Chromatography and Mass Spectrometry (MS)

Bruker-400M-NMRBruker 400M NMR

Chromatography is a technique to separate mixtures. Using different mobile phase and stationary phase, mixtures could be separated, identified and quantified. Detectors could be selected to capture signals of different categories of compounds. Peak areas are used to calculate the ratios of each ingredient.

Mass spectrometry works by ionizing chemical compounds to generate charged molecules or molecule fragments and measuring their mass-to-charge ratios. The spectra are used to determine the elemental or isotopic signature of a sample with the mass peaks of particles and molecules, therefore elucidating the fragments information of molecules. Mass Spectrometry is very important to confirming the identity of a target molecule.

Combining the use of Chromatography and Mass Spectrometry can expand the sample selection and benefit both purposes. For submitted samples, the ingredients could be separated, quantified and identified at the same time.

  • X-Ray Crystallography

X-Ray Diffraction (XRD) is a useful tool for identifying the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions. By measuring the intensities and angles of these diffracted beams, a crystallographer is capable of producing a 3D picture of the electron density within the crystal. From this electron density, the positions of the atoms in the crystal can be determined, as well as the chemical bonds, the disorder and various other information. X-Ray Powder Diffraction (XPRD) is a rapid analytical technique primarily used for phase identification of a crystalline material and can provide information on unit cell dimensions.

BOC Sciences can provide general test services of high quality and fast turnaround time. With strong scientific knowledge and experience in the regulatory requirements of both the international and domestic industry market, analytical development group at BOC Sciences has evolved to interleave with drug discovery, pharmaceutical development and manufacturing.

References

  1. Thevis, M., & Schänzer, W. (2007). Mass spectrometry in sports drug testing: structure characterization and analytical assays. Mass spectrometry reviews26(1), 79-107.
  2. Walter, C., Bécheiraz, F., Gerber, M., & Rohner, R. (2016). U.S. Patent No. 9,297,821. Washington, DC: U.S. Patent and Trademark Office.
  3. Gabbaï, F. P., Chirik, P. J., Fogg, D. E., Meyer, K., Mindiola, D. J., Schafer, L. L., & You, S. L. (2016). An Editorial About Elemental Analysis.
HPLC-Agilent HPLC Agilent
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LCMS-Q-ExactiveLCMS Q Exactive