Bacteriophage MS2 As a Tool for Targeted Delivery in Solid Tumor Chemotherapy

Kolesanova, E. F., Melnikova, M. V., Bolshakova, T. N., Rybalkina, E. Y., & Sivov, I. G.

Acta naturae 11.2 (2019): 98.

Bacteriophage MS2 was employed for targeted delivery of an apoptosis-inducing agent, Tl+, into a tumor tissue. The targeted delivery was ensured by iRGD peptide, a ligand of integrins presumably located on the surface of endotheliocytes of the tumor tissue neovasculature and certain tumor cells. The synthesized peptide was conjugated to MS2 capsid proteins. Tl+ ions from TlNO3 penetrated the phage particles and tightly bound to phage RNA. Peptide-modified MS2 preparations filled with Tl+ caused cell death in two types of cultivated human breast cancer cells and effected necrosis of these tumor xenografts in mice. Neither peptide-conjugated bacteriophage MS2 without Tl+ nor the phage filled with Tl+ but without the peptide or the same phage with the non-conjugated peptide in solution produced such effects. The preparation exhibited no acute toxicity at a therapeutic dose.

Bacteriophage MS2 As a Tool for Targeted Delivery in Solid Tumor Chemotherapy

Products Used in this Publication

Catalog NumberCASProduct NamePrice
6528-53-66528-53-61,3,6,8-Pyrenetetrasulphonic acidInquiry

Related Products

Catalog NumberCASProduct NamePrice
B0052-02946759572-10-01,3,6,8-PYRENETETRASULFONIC ACID TETRASODIUM SALTInquiry