Total Synthesis of Nosiheptide

Wojtas, K. P., Riedrich, M., Lu, J. Y., Winter, P., Winkler, T., Walter, S., & Arndt, H. D.

Angewandte Chemie International Edition 55.33 (2016): 9772-9776.

Total synthesis of the bismacrocyclic thiopeptide antibiotic nosiheptide was achieved through the assembly of a fully functionalized linear precursor followed by consecutive macrocyclizations. Key features are a critical macrothiolactonization and a mild deprotection strategy for the 3‐hydroxypyridine core. The natural product was identical to isolated authentic material in terms of spectral data and antibiotic activity.


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