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Schisanhenol
Schisanhenol Chemical Structure

Schisanhenol

Catalog NO.: B0005-465627 CAS NO.: 69363-14-0 Brand: BOC Sciences

Category
Natural Compounds
Chemical Family/Application
Lignans
Molecular Formula
C23H30O6
Molecular Weight
402.487
Size Price Stock Quantity
20 mg $285 In stock

Request another packsize? Click Bulk Order.

WARNING: Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
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Product Description

Schisanhenol has antioxidative effect on human LDL oxidation. The mechanism of Schisanhenol against LDL oxidation may be through scavenging free radicals.

Quantity
Milligrams-Grams
InChI Key
FYSHYFPJBONYCQ-QWHCGFSZSA-N
InChI
1S/C23H30O6/c1-12-8-14-10-16(25-3)21(27-5)20(24)18(14)19-15(9-13(12)2)11-17(26-4)22(28-6)23(19)29-7/h10-13,24H,8-9H2,1-7H3/t12-,13+/m0/s1
SMILES
CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1C)OC)OC)OC)O)OC)OC
Write a review Ask a question

What is the regulatory role of Schisanhenol in liver microsomes?

Schisanhenol completely inhibits iron and cysteine-induced malondialdehyde (MDA) formation in rat liver microsomes when used at a concentration of 1 mM.

15/5/2019

Dear team. Can Schisanhenol be applied to plants?

Of course! Schisanhenol is protective against tobacco mosaic virus (TMV) infection in N. glutinosa when applied to leaves at concentrations ranging from 0.15 to 0.5 mM.

12/5/2020

Hello, do you have any data on Schisanhenol regulates hippocampal MDA in mice?

Schisanhenol (10, 30, or 100 mg/kg, i.p.) prevents scopolamine-induced increases in hippocampal MDA and acetylcholinesterase (AChE) levels and decreases hippocampal superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, as well as increases time spent in the target quadrant in the Morris water maze in mice.

3/9/2020

protect mitochondrial

Schisanhenol significantly inhibited the rigidification of mitochondrial membrane, as well as swelling, lysis and disintegration of the mitochondria induced by ferrous-cysteine.

14/1/2016

inhibit apoptosis

Great performance! Schisanhenol attenuated ox-LDL-induced BAECs apoptosis as indicated in typical internucleosomal DNA degradation (DNA ladder), condensed chromatin, and the sub-G1 peak appearance in flow cytometry assay.

11/6/2018

exhibit antioxidant activity

In vitro, the ferrous-cysteine induced mitochondrial lipid peroxidation was significantly inhibited by Schisanhenol, while the loss of ATPase activity induced by the lipid peroxidation was prevented.

5/3/2022

1.Schisanhenol derivatives and their biological evaluation against tobacco mosaic virus (TMV).
Wang QY1, Deng LL2, Liu JJ2, Zhang JX2, Hao XJ2, Mu SZ3. Fitoterapia. 2015 Mar;101:117-24. doi: 10.1016/j.fitote.2015.01.006. Epub 2015 Jan 15.
Schisanhenol (Sol) was isolated from Schisandra rubriflora, and a series of derivatives (1-16, 15a-16a, and 15b-16b) were designed and prepared by chemical modification. The curative and protective effects of these dibenzocyclooctadiene lignan analogues against tobacco mosaic virus (TMV) were evaluated. Most analogues exhibited stronger protective effects than the positive control ningnanmycin. Dibromoschisanhenol (6) at 0.25mM exhibited the strongest protective activity (83.5±1.8% at 0.25mM), and 14-(3, 5-dibenzyloxy)-benzoyloxyschisanhenol (16) showed a significant curative effect (78.0±3.8% at 0.15mM) that was much stronger than that of the commercial virucide ningnanmycin. This study is the first to demonstrate that natural dibenzocyclooctadiene lignans and analogues are active against plant viruses.
2.Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis.
Song JH1, Cui L1, An LB2, Li WT2, Fang ZZ3, Zhang YY4, Dong PP5, Wu X6, Wang LX6, Gonzalez FJ7, Sun XY6, Zhao DW1. Phytother Res. 2015 Oct;29(10):1658-64. doi: 10.1002/ptr.5395. Epub 2015 Jun 18.
Structure-activity relationship for the inhibition of Schisandra chinensis's ingredients toward (Uridine-Diphosphate) UDP-glucuronosyltransferases (UGTs) activity was performed in the present study. In vitro incubation system was employed to screen the inhibition capability of S. chinensis's ingredients, and in silico molecular docking method was carried out to explain possible mechanisms. At 100 μM of compounds, the activity of UGTs was inhibited by less than 90% by schisandrol A, schisandrol B, schisandrin, schisandrin C, schisantherin A, gomisin D, and gomisin G. Schisandrin A exerted strong inhibition toward UGT1A1 and UGT1A3, with the residual activity to be 7.9% and 0% of control activity. Schisanhenol exhibited strong inhibition toward UGT2B7, with the residual activity to be 7.9% of control activity. Gomisin J of 100 μM inhibited 91.8% and 93.1% of activity of UGT1A1 and UGT1A9, respectively. Molecular docking prediction indicated different hydrogen bonds interaction resulted in the different inhibition potential induced by subtle structure alteration among schisandrin A, schisandrin, and schisandrin C toward UGT1A1 and UGT1A3: schisandrin A > schisandrin > schisandrin C.
3.Chemical analysis of twelve lignans in the fruit of Schisandra sphenanthera by HPLC-PAD-MS.
Liu H1, Zhang J, Li X, Qi Y, Peng Y, Zhang B, Xiao P. Phytomedicine. 2012 Oct 15;19(13):1234-41. doi: 10.1016/j.phymed.2012.07.017. Epub 2012 Aug 18.
The fruit of S. sphenanthera, known as "Nanwuweizi", has been widely used as traditional Chinese medicine for several thousand years. However, the current determination methods are not sufficient to evaluate its quality. An accurate, sensitive and reliable high performance liquid chromatography coupled with photodiode array detection and mass spectrum (HPLC-PAD-MS) was developed for quantitative analysis of twelve lignans (schisandrol A, schisandrol B, gomisin G, schisantherin A, schisantherin D, schisanhenol, (+)-anwulignan, deoxyschisandrin, schisandrin B, schisandrin C, 6-O-benzoylgomisin O, and interiotherin A) in the fruit of S. sphenanthera. The chromatographic conditions and extraction procedures were optimized during the study. The identity of chromatographic peaks in the sample HPLC profiles was confirmed by comparing the retention time, ultraviolet (UV) spectra and MS data with reference compounds. The validated method was successfully used to determine the twelve lignans in the samples collected from different localities in China.
4.Attenuation of Oxidative Stress in HEK 293 Cells by the TCM Constituents Schisanhenol, Baicalein, Resveratrol or Crocetin and Two Defined Mixtures.
Bend JR1, Xia XY, Chen D, Awaysheh A, Lo A, Rieder MJ, Rylett RJ. J Pharm Pharm Sci. 2015;18(4):661-82.
PURPOSE: Our working hypothesis is that single bioactive phytochemicals with antioxidant properties that are important constituents of Traditional Chinese Medicine (TCM) and their defined mixtures have potential as chemoprotective agents for chronic conditions characterized by oxidative and nitrosative stress, including Alzheimer's. Here we evaluate the ability of baicalein, crocetin, trans-resveratrol or schisanhenol and two defined mixtures of these TCM phytochemicals to attenuate the toxicity resulting from exposure to cell permeant t-butyl hydroperoxide (tBPH) in wild-type and bioengineered (to express choline acetyltransferase) HEK 293 cells.
Preparing Stock Solutions
ConcentrationVolumeMass1 mg5 mg10 mg
1 mM2.4846 mL12.4230 mL24.8460 mL
5 mM0.4969 mL2.4846 mL4.9692 mL
10 mM0.2485 mL1.2423 mL2.4846 mL
50 mM0.0497 mL0.2485 mL0.4969 mL
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