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Salicylic acid
Salicylic acid Chemical Structure

Salicylic acid

Catalog NO.: 69-72-7 CAS NO.: 69-72-7 Brand: BOC Sciences

Category
Impurities
Tag
Lamivudine and Impurities Aspirin and Impurities Mesalamine and Impurities Sulfasalazine and Impurities
Molecular Formula
C7H6O3
Molecular Weight
138.12

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cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
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Product Description

Salicylic acid is a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. It is widely used in organic synthesis and functions as a plant hormone and is known for its ability to ease aches and pains and reduce fevers. It is derived from the metabolism of salicin. It and its derivatives are used as constituents of some rubefacient products. In cosmetics, it has the effect of oil control, exfoliation, removing pimples, narrowing pores, and lightening marks.

Quantity
Grams-Kilos
Boiling Point
~211 °C (approx) at 20 Torr
Melting Point
157-159 °C
Density
1.443 g/cm3
InChI Key
YGSDEFSMJLZEOE-UHFFFAOYSA-N
InChI
InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
SMILES
C1=CC=C(C(=C1)C(=O)O)O
Refractive Index
1.565
Stability
Stable. Substances to be avoided include oxidizing agents, strong bases, iodine, fluorine. Combustible. Sensitive to light.
NCT NumberTitleCondition Or DiseasePhaseStart DateSponsorStatus
NCT04002024Moisturizer Containing Licochalcone A, Decanediol, L-carnitine and Salicylic Acid in Reducing Relapsing of AcneAcne VulgarisAcnePhase 2June 1, 2019Mahidol University,Mahidol UniversityCompleted
NCT02694848Clinical Study of Combination Therapy for Angina of Coronary Heart Disease With Aspirin and Salvianolate InjectionAnginaPhase 4February 2016China Academy of Chinese Medical Sciences,China Academy of Chinese Medical SciencesUnknown
NCT02394093To Evaluate the Bioavailability of a Single Oral Dose of the Acetylsalicylic Acid Containing Dry Powder 500 mg in Comparison to the Bioavailability of a Single Oral Dose of Aspirin Tablets and Aspirin Effervescent Tablets in Healthy Adults. (Icicle)Pharmacology, ClinicalPhase 1February 2015Bayer,BayerCompleted
NCT03056703Bioequivalence of Single Dose Fast Release Aspirin (1000 mg) Tablet Versus Single Dose of Two 500 mg Fast Release Aspirin Tablets (Mille)PainPhase 1February 2014Bayer,BayerCompleted
NCT01657071Comparative Pharmacokinetics of YH14659 in Healthy Male SubjectsAcute Coronary SyndromePhase 1March 2012Yuhan CorporationCompleted
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Is Salicylic acid? natural or synthetic compound?

Salicylic acid can be found naturally in various plants, including willow trees, and can also be synthesized chemically. The salicylic acid used in commercial and pharmaceutical products is typically synthesized.

1/6/2017

What is the pKa value of Salicylic acid?

The pKa value of Salicylic acid is 2.97.

22/5/2021

1.Viral protein suppresses oxidative burst and salicylic acid-dependent autophagy and facilitates bacterial growth on virus-infected plants.
Zvereva AS1, Golyaev V1, Turco S1, Gubaeva EG1, Rajeswaran R1, Schepetilnikov MV2, Srour O2, Ryabova LA2, Boller T1, Pooggin MM1. New Phytol. 2016 Apr 27. doi: 10.1111/nph.13967. [Epub ahead of print]
Virus interactions with plant silencing and innate immunity pathways can potentially alter the susceptibility of virus-infected plants to secondary infections with nonviral pathogens. We found that Arabidopsis plants infected with Cauliflower mosaic virus (CaMV) or transgenic for CaMV silencing suppressor P6 exhibit increased susceptibility to Pseudomonas syringae pv. tomato (Pst) and allow robust growth of the Pst mutant hrcC-, which cannot deploy effectors to suppress innate immunity. The impaired antibacterial defense correlated with the suppressed oxidative burst, reduced accumulation of the defense hormone salicylic acid (SA) and diminished SA-dependent autophagy. The viral protein domain required for suppression of these plant defense responses is dispensable for silencing suppression but essential for binding and activation of the plant target-of-rapamycin (TOR) kinase which, in its active state, blocks cellular autophagy and promotes CaMV translation.
2.UV-C-Induced alleviation of transcriptional gene silencing through plant-plant communication: Key roles of jasmonic acid and salicylic acid pathways.
Xu W1, Wang T1, Xu S2, Li F1, Deng C1, Wu L1, Wu Y1, Bian P3. Mutat Res. 2016 Apr 27. pii: S0027-5107(16)30048-3. doi: 10.1016/j.mrfmmm.2016.04.003. [Epub ahead of print]
Plant stress responses at the epigenetic level are expected to allow more permanent changes of gene expression and potentially long-term adaptation. While it has been reported that plants subjected to adverse environments initiate various stress responses in their neighboring plants, little is known regarding epigenetic responses to external stresses mediated by plant-plant communication. In this study, we show that DNA repetitive elements of Arabidopsis thaliana, whose expression is inhibited epigenetically by transcriptional gene silencing (TGS) mechanism, are activated by UV-C irradiation through airborne plant-plant and plant-plant-plant communications, accompanied by DNA demethylation at CHH sites. Moreover, the TGS is alleviated by direct treatments with exogenous methyl jasmonate (MeJA) and methyl salicylate (MeSA). Further, the plant-plant and plant-plant-plant communications are blocked by mutations in the biosynthesis or signaling of jasmonic acid (JA) or salicylic acid (SA), indicating that JA and SA pathways are involved in the interplant communication for epigenetic responses.
3.Salicylic acid confers enhanced resistance to Glomerella leaf spot in apple.
Zhang Y1, Shi X1, Li B1, Zhang Q2, Liang W1, Wang C3. Plant Physiol Biochem. 2016 Apr 26;106:64-72. doi: 10.1016/j.plaphy.2016.04.047. [Epub ahead of print]
Glomerella leaf spot (GLS) caused by Glomerella cingulata is a newly emergent disease that results in severe defoliation and fruit spots in apple. Currently, there are no effective means to control this disease except for the traditional fungicide sprays. Induced resistance by elicitors against pathogens infection is a widely accepted eco-friendly strategy. In the present study, we investigated whether exogenous application of salicylic acid (SA) could improve resistance to GLS in a highly susceptible apple cultivar (Malus domestica Borkh. cv. 'Gala') and the underlying mechanisms. The results showed that pretreatment with SA, at 0.1-1.0 mM, induced strong resistance against GLS in 'Gala' apple leaves, with SA treated leaves showing significant reduction in lesion numbers and disease index. Concurrent with the enhanced disease resistance, SA treatment markedly increased the total antioxidant capacity (T-AOC) and defence-related enzyme activities, including catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), phenylalanine ammonia-lyase (PAL) and polyphenol oxidase (PPO).
4.Tobacco mosaic virus-directed reprogramming of auxin/indole acetic acid protein transcriptional responses enhances virus phloem loading.
Collum TD1, Padmanabhan MS1, Hsieh YC2, Culver JN3. Proc Natl Acad Sci U S A. 2016 Apr 26. pii: 201524390. [Epub ahead of print]
Vascular phloem loading has long been recognized as an essential step in the establishment of a systemic virus infection. In this study, an interaction between the replication protein of tobacco mosaic virus (TMV) and phloem-specific auxin/indole acetic acid (Aux/IAA) transcriptional regulators was found to modulate virus phloem loading in an age-dependent manner. Promoter expression studies show that in mature tissues TMV 126/183-kDa-interacting Aux/IAAs predominantly express and accumulate within the nuclei of phloem companion cells (CCs). Furthermore, CC Aux/IAA nuclear localization is disrupted upon infection with an interacting virus. In situ analysis of virus spread shows that the inability to disrupt Aux/IAA CC nuclear localization correlates with a reduced ability to load into the vascular tissue. Subsequent systemic movement assays also demonstrate that a virus capable of disrupting Aux/IAA localization is significantly more competitive at moving out of older plant tissues than a noninteracting virus.
Preparing Stock Solutions
ConcentrationVolumeMass1 mg5 mg10 mg
1 mM7.2401 mL36.2004 mL72.4008 mL
5 mM1.4480 mL7.2401 mL14.4802 mL
10 mM0.7240 mL3.6200 mL7.2401 mL
50 mM0.1448 mL0.7240 mL1.4480 mL
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