webinar
Live Imaging of the Extracellular Matrix With a Glycan-Binding Fluorophore
June 9th, 2026 10:00 AM EDT
Register
Shopping Cart 0
Tel:
Email:
  1. Home
  2. Products
  3. Drug Discovery
  4. Inhibitor
  5. Cardiovascular and blood system
  6. Calcium Channel
  7. Ginsenoside Ro
Ginsenoside Ro
Ginsenoside Ro Chemical Structure

Ginsenoside Ro

Catalog NO.: B0005-464399 CAS NO.: 34367-04-9 Brand: BOC Sciences

Category
Inhibitor
Tag/Targets
Calcium Channel
Molecular Formula
C48H76O19
Molecular Weight
957.13
Size Price Stock Quantity
20 mg $285 In stock

Request another packsize? Click Bulk Order.

WARNING: Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
Read More

Product Description

Ginsenoside Ro, the predominant ginsenoside in the rhizome, shows inhibitory activity against 5αR. It demonstrates significant anti-thrombic, anti-inflammatory, and anti-hepatitis activities in experimental models. It shows no hemolytic nor cytotoxic activities.

Quantity
Milligrams-Grams
InChI Key
NFZYDZXHKFHPGA-QQHDHSITSA-N
InChI
InChI=1S/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23+,24+,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,39-,40-,41+,45-,46+,47+,48-/m0/s1
SMILES
CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(C(O6)C(=O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)C)C)C2C1)C)C(=O)OC8C(C(C(C(O8)CO)O)O)O)C
Write a review Ask a question

Dear Sirs, what is the activity of Ginsenoside Ro in vivo?

Hi, Ginsenoside Ro produces a significant decrease in the number of tumor nodules on the lung surface, yielding inhibition rates of 88% (P<0.01).

23/1/2016

Dear sir, how does Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes?

Hi, Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB.

1/2/2017

Good afternoon, and how does Ginsenoside Ro exert anti-inflammatory effect?

Welcome. Ginsenoside Ro exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway.

5/2/2018

May I know how Ginsenoside Roexerts anti-inflammatory effect?

Sure! Ginsenoside Ro exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway.

7/5/2020

Dear BocSci, how does Ginsenoside Ro suppresseinterleukin-1β-induced apoptosis and inflammation in rat chondrocytes?

Welcome! Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB.

26/6/2021

I would appreciate it if you could answer my questions. How Ginsenoside Ro ameliorates high-fat diet-induced obesity and insulin resistance in mice.

No thanks. Ginsenoside Ro ameliorates high-fat diet-induced obesity and insulin resistance in mice via activation of the G protein-coupled bile acid receptor 5 pathway.

13/2/2022

suppress tumour growth

Its activity and safety are very good! Ginsenoside Ro considerably suppressed tumour growth with no significant side effects on immune organs and body weight in mice.

1/4/2016

inhibit the phosphorylation of NF-κB and MAPKs as well as the p65 subunit nuclear translocation

The phosphorylation of NF-κB and MAPKs as well as the p65 subunit nuclear translocation were inhibited by Ginsenoside Ro dose-dependently. The inhibitive effect was very good and specific.

7/6/2017

reduce thrombin-stimulated platelet aggregation

The effect expected was seen with it! Ginsenoside Ro dose-dependently reduces thrombin-stimulated platelet aggregation, and IC50 is approximately 155 μM.

10/5/2020

suppress LPS-triggered lung injury in rats

In our lab, Ginsenoside Ro can markedly suppress LPS-triggered lung injury, the transcription and secretion levels of TNF-α, IL-6 and IL-1β in rats. Really good product.

5/10/2021

inhibit TXA2 production

Ginsenoside Ro do well in inhibiting TXA2 production to abolish thrombin-induced platelet aggregation in our study.

27/6/2022

increase cell viability

This agent worked perfectly in cell viability assay. Pretreatment with Ginsenoside Ro for 1 h prior to LPS incubation for 24 h leads to a significant increase in cell viability.

31/12/2022

1.Inhibitory Effects of Cytosolic Ca(2+) Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets.
Kwon HW1, Shin JH1, Lee DH2, Park HJ1. Evid Based Complement Alternat Med. 2015;2015:764906. doi: 10.1155/2015/764906. Epub 2015 Aug 19.
Intracellular Ca(2+) ([Ca(2+)] i ) is platelet aggregation-inducing molecule and is involved in activation of aggregation associated molecules. This study was carried out to understand the Ca(2+)-antagonistic effect of ginsenoside Ro (G-Ro), an oleanane-type saponin in Panax ginseng. G-Ro, without affecting leakage of lactate dehydrogenase, dose-dependently inhibited thrombin-induced platelet aggregation, and the half maximal inhibitory concentration was approximately 155 μM. G-Ro inhibited strongly thrombin-elevated [Ca(2+)] i , which was strongly increased by A-kinase inhibitor Rp-8-Br-cAMPS compared to G-kinase inhibitor Rp-8-Br-cGMPS. G-Ro increased the level of cAMP and subsequently elevated the phosphorylation of inositol 1, 4, 5-triphosphate receptor I (IP3RI) (Ser(1756)) to inhibit [Ca(2+)] i mobilization in thrombin-induced platelet aggregation. Phosphorylation of IP3RI (Ser(1756)) by G-Ro was decreased by PKA inhibitor Rp-8-Br-cAMPS.
2.Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts.
Kang HJ1, Oh Y1, Lee S2, Ryu IW1, Kim K1, Lim CJ2. Biosci Biotechnol Biochem. 2015;79(12):2018-21. doi: 10.1080/09168451.2015.1065170. Epub 2015 Jul 27.
Ginsenoside Ro (Ro), an oleanolic acid-type ginsenoside, exhibited suppressive activities on reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) elevation in UV-B-irradiated fibroblasts. Ro could overcome the reduction of the total glutathione (GSH) contents in UV-B-irradiated fibroblasts. Ro could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Collectively, Ro possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts.
3.Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells.
Kim S1, Oh MH1, Kim BS2, Kim WI2, Cho HS2, Park BY2, Park C2, Shin GW2, Kwon J3. J Ginseng Res. 2015 Oct;39(4):365-70. doi: 10.1016/j.jgr.2015.03.008. Epub 2015 Apr 4.
BACKGROUND: The beneficial effects of ginsenoside species have been well demonstrated in a number of studies. However, the function of ginsenoside Ro (GRo), an oleanane-type saponin, has not been sufficiently investigated. Thus, the aim of the present study was to investigate the anti-inflammatory effects of GRo in vitro using the Raw 264.7 mouse macrophage cell line treated with lipopolysaccharide (LPS), and to clarify the possible mechanism of GRo involving heme oxygenase-1 (HO-1), which itself plays a critical role in self-defense in the presence of inflammatory stress.
4.Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB.
Zhang XH1, Xu XX2, Xu T1. Chin J Nat Med. 2015 Apr;13(4):283-9. doi: 10.1016/S1875-5364(15)30015-7.
This study investigated effects of Ginsenoside Ro (Ro) on interleukin-1β (IL-1β)-induced apoptosis and inflammation in rat chondrocytes. The rat chondrocytes were co-treated with IL-1β (10 ng·kg(-1)) and Ro (50, 100 and 200 μmol·L(-1)) for 48 h. Chondrocytes viability was detected by the MTT assay and Annexin V-FITC/PI dual staining assay. Caspase 3 activity was measured by using caspase 3 colorimetric assay kit. Apoptosis related proteins Bax, Bad, Bcl-xL, PCNA, p53 and phospho-p53, along with inflammation related protein MMP 3, MMP 9 and COX-2, and the expression of phospho-NF-κB p65 were assayed by western blotting analyses. Ro could improve IL-1β-induced chondrocytes viability. Ro could suppress IL-1β-induced apoptosis by inhibiting levels of Bax and Bad, decreasing p53 phosphorylation and promoting the expression of Bcl-xL and PCNA. Ro inhibited caspase 3 activity. IL-1β-induced inflammation and matrix degration were also alleviated by Ro with down-regulating the expression of MMP 3, MMP 9 and COX-2.
About Us

BOC Sciences is a trusted global supplier of research chemicals, biochemicals, and pharmaceutical ingredients, serving the life sciences, biotech, and pharmaceutical industries. Headquartered in New York, we offer a comprehensive product portfolio that includes inhibitors, building blocks, carbohydrates, nucleosides, nucleotides, GMP products, impurities and metabolites, APIs, natural compounds, ADC-related chemicals, and stem cell molecules.

We specialize in the synthesis, biosynthesis, purification, and characterization of small molecules. With years of industry experience, our scientific and technical teams support projects ranging from early discovery to process development and regulatory submission.

BOC Sciences operates GMP-compliant and ISO-certified production facilities, ensuring consistent quality and regulatory alignment. Our products and services are trusted by clients in over 60+ countries, including top pharmaceutical companies, academic institutions, and research organizations.

We are committed to providing high-quality chemicals, responsive technical support, and flexible custom solutions to accelerate innovation in drug discovery and development.

Our Clients

Online Inquiry

Basic Information
How did you hear about BOC Sciences?
Verification code