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Ginsenoside-Rb3
Ginsenoside-Rb3 Chemical Structure

Ginsenoside-Rb3

Catalog NO.: B0005-465150 CAS NO.: 68406-26-8 Brand: BOC Sciences

Category
Inhibitor
Tag/Targets
Cox-2 Nitric oxide synthase (NOS)
Molecular Formula
C53H90O22
Molecular Weight
1079.27
Size Price Stock Quantity
20 mg $199 In stock

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WARNING: Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
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Product Description

Ginsenoside Rb3 is a natural triterpenoid saponin. It has various pharmacological effects. It possesses the effect against isoproterenol-induced myocardial injury and heart function impairment, and that the mechanism of pharmacological action was related to the antioxidant activity of ginsenoside Rb3 at least in part. It could markedly protected OGD-Rep induced ischemic injury and the mechanisms maybe related to its suppression of the intracellular Ca2+ elevation and inhibition of apoptosis and caspase activity. It could be a promising candidate in the development of a novel class of anti-ischemic agent.

Quantity
Milligrams-Grams
Melting Point
193-195 °C
InChI Key
NODILNFGTFIURN-USYOXQFSSA-N
InChI
InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-69-45-41(65)34(58)26(57)21-68-45)24-11-16-52(7)33(24)25(56)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)36(60)28(20-55)71-48)74-46-42(66)38(62)35(59)27(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-,46-,47-,48-,50-,51+,52+,53-/m0/s1
SMILES
CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)OC7C(C(C(C(O7)COC8C(C(C(CO8)O)O)O)O)O)O)C
Write a review Ask a question

Please tell me how Ginsenoside-Rb3 regulates energy metabolism and apoptosis in cardiomyocytes.

OK, Ginsenoside-Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway.

16/12/2016

Do you know how Ginsenoside-Rb3 inhibits osteoclastogenesis?

Yes, I do. Ginsenoside-Rb3 inhibits osteoclastogenesis via ERK/NF-κB signaling pathway in vitro and in vivo.

7/10/2022

Good afternoon, and how does Ginsenoside-Rb3 attenuates skin flap ischemia-reperfusion damage in rats?

Welcome! Ginsenoside-Rb3 attenuates skin flap ischemia-reperfusion damage in rats by inhibiting STING-IRF3 signaling.

30/12/2022

up-regulate expressions of key enzymes involved in β-oxidation of fatty acids

This product has been working really well for us. In our study, Ginsenoside-Rb3 treatment can up-regulate expressions of key enzymes involved in β-oxidation of fatty acids, including carnitine palmitoyltransterase-1α (CPT-1α), acyl-CoA dehydrogenase long chain (ACADL) and the major mitochondrial deacetylase enzyme sirtuin 3 (SIRT3).

18/2/2019

reduce the amount of STING protein, phosphorylated IRF3, and P-selectin

Ginsenoside-Rb3 do well in reducing the amount of STING protein, phosphorylated IRF3, and P-selectin in skin flap tissue, with this change being most obvious in microvascular endothelial cells in our research.

22/9/2019

inhibit RANKL-induced osteoclastogenesis

The inhibitive effect was very specific. Ginsenoside-Rb3 dramatically inhibits RANKL-induced osteoclastogenesis. Nfatc1, Mmp9, Ctsk, Acp5 mRNA, and MMP9, CTSK proteins were dose-dependently downregulated by Ginsenoside-Rb3 pretreatment.

27/8/2021

1.[Screening of pregnane X receptor activation from ginsenosides].
Wang YG1, Liu HS, Zhang XX, Xiao Y, Lu BB, Ma ZC, Liang QD, Tang XL, Xiao CR, Tan HL, Zhang BL, Gao Y. Yao Xue Xue Bao. 2013 Jan;48(1):144-8.
In order to study effects of ginseng on the metabolism of drug belong to CYP3A4 substrate, screening of pregnane X receptor activation from ginsenosides was performed by reporter assay. Based on PXR-CYP3A stable translation cell lines, 13 ginsenosides were screened for pregnane X receptor activation by reporter assays, and RIF as the positive control. The effect of ginsenosides Rg1 onCYP3A4 mRNA expression was also investigated by RT-PCR. The PXR-CYP3A stable translation cell lines had good response to RIF, and the EC50 is 2.51 micro mol x L(-1). When the condition of final concentration was 10 micromol x L(-1), ginsenoside F2 and protopanaxatriol had moderate inductive effects on PXR. Panaxotriol, Rg2, pseudoginsenoside F11, Rg1, ginsenoside and Rb3 had inhibitory effects on PXR. Ginsenoside Rf1, Rg3, Rh2 and protopanaxdiol had no obvious effects on PXR. Rg1 down-regulated CYP3A4 mRNA expression in a concentration-dependent manner. Activation of pregnane X receptor by ginsenosides may influence the metabolism of drug belong to CYP3A4 substrate, and cause ginseng-drug interactions.
2.Antidepressant-like effects of ginsenosides: A comparison of ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K, and 20(S)-protopanaxadiol in mice models of despair.
Zhang H1, Li Z2, Zhou Z3, Yang H3, Zhong Z4, Lou C4. Pharmacol Biochem Behav. 2016 Jan;140:17-26. doi: 10.1016/j.pbb.2015.10.018. Epub 2015 Oct 31.
Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone. However, it is commonly accepted that orally ingested ginsenosides can be deglycosylated or partially deglycosylated into active derivatives by the intestinal bacteria. To identify potential antidepressant drug candidates, we compared the antidepressant-like activities between ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K (C-K), and PPD. Effects of acute (1-day), short chronic (7-days), and longer chronic treatments (14-days) with these ginsenosides (50 and 100mg/kg, p.o.) on the behavioral changes in the forced swim test (FST), tail suspension test (TST) and open field test were investigated. Serum corticosterone and adrenocorticotropic hormone (ACTH) levels and mouse brain monoamine neurotransmitters 5-HT, NA and DA levels were measured using commercially available competitive enzyme-linked immunosorbent assay (ELISA) kits.
3.Ginsenoside Rb3 protects cardiomyocytes against ischemia-reperfusion injury via the inhibition of JNK-mediated NF-κB pathway: a mouse cardiomyocyte model.
Ma L1, Liu H1, Xie Z1, Yang S1, Xu W1, Hou J1, Yu B1. PLoS One. 2014 Aug 1;9(8):e103628. doi: 10.1371/journal.pone.0103628. eCollection 2014.
Ginsenoside Rb3 is extracted from the plant Panax ginseng and plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. NF-κB is an important transcription factor involved in I/R injury. However, the underlying mechanism of ginsenoside Rb3 in myocardial I/R injury remains poorly understood. In the current study, a model of myocardial I/R injury was induced via oxygen and glucose deprivation (OGD) followed by reperfusion (OGD-Rep) in mouse cardiac myoblast H9c2 cells. Our data demonstrate that ginsenoside Rb3 suppresses OGD-Rep-induced cell apoptosis by the suppression of ROS generation. By detecting the NF-κB signaling pathway, we discover that the protective effect of ginsenoside Rb3 on the OGD-Rep injury is closely related to the inhibition of NF-κB activity. Ginsenoside Rb3 inhibits the upregulation of phospho-IκB-α and nuclear translocation of NF-κB subunit p65 which are induced by ORD-Rep injury.
4.Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats.
Wang Y1, Dong J, Liu P, Lau CW, Gao Z, Zhou D, Tang J, Ng CF, Huang Y. Br J Pharmacol. 2014 Jul;171(13):3171-81. doi: 10.1111/bph.12660.
BACKGROUND AND PURPOSE: Panax ginseng is commonly used to treat cardiovascular conditions in Oriental countries. This study investigated the mechanisms underlying the vascular benefits of ginsenoside Rb3 (Rb3) in hypertension.
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