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Colominic acid sodium salt
Colominic acid sodium salt Chemical Structure

Colominic acid sodium salt

Catalog NO.: B2705-199133 CAS NO.: 70431-34-4 Brand: BOC Sciences

Category
Inhibitor
Targets
Antibiotic
Molecular Formula
(C11H16NNaO8)n
Size Price Stock Quantity
100 mg $199 In stock

Request another packsize? Click Bulk Order.

WARNING: Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
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Product Description

Colominic acid sodium salt is an exquisite compound, used for studying bacterial infections evoked by Streptococcus pneumoniae and Haemophilus influenzae. Unveiling its remarkable antimicrobial activity, this compound emerges as a quintessential constituent within pharmaceutical formulations, including antibiotics and vaccines.

HPLC
MW Control
Endotoxin Control

Colominic Acid Sodium Salt is a linear homopolymer of sialic acid (N-acetylneuraminic acid) widely used in biochemical and biomedical research. As the sodium salt form, it exhibits excellent solubility and stability, making it ideal for laboratory applications. This compound closely resembles the polysialic acid structures naturally found in bacterial capsules and mammalian neural cell adhesion molecules (NCAMs), giving it significant biological relevance. Researchers value Colominic Acid Sodium Salt for its biocompatibility, ability to mimic natural glycans, and role in modulating cellular interactions. Its unique structural properties support studies in glycobiology, immunology, and neurobiology, as well as pharmaceutical and biomaterial innovations. Due to its versatile characteristics, Colominic Acid Sodium Salt is increasingly applied in drug delivery, tissue engineering, and as a reference standard for carbohydrate-based studies. Its wide scope of use and compatibility with bio-conjugation techniques make it a vital reagent for academic research and industrial product development.

1. Drug Delivery Systems

Colominic Acid Sodium Salt is extensively applied in the design of drug delivery vehicles due to its biocompatibility and structural similarity to naturally occurring polysialic acids. It acts as a hydrophilic coating for nanoparticles and liposomes, enhancing solubility and prolonging circulation time in vivo. Its anti-immunogenic nature reduces immune recognition, making it a valuable excipient for advanced pharmaceutical formulations.

2. Immunology Studies

In immunological research, Colominic Acid Sodium Salt is applied as a model antigen to explore bacterial pathogenesis and host–pathogen interactions. Its resemblance to bacterial capsular polysaccharides provides insight into immune evasion mechanisms, making it an effective reagent for vaccine development and antibody testing.

3. Vaccine Development

This compound plays an important role in vaccine research as a structural mimic of bacterial polysialic acids. It helps design conjugate vaccines that elicit strong immune responses against encapsulated pathogens. Its non-toxic, biocompatible profile makes it suitable as a safe vaccine component.

4. Cell Therapy

Colominic Acid Sodium Salt is increasingly studied in regenerative medicine and cell therapy. By modulating cell–cell interactions and providing a protective glycocalyx-like layer, it enhances cell viability, reduces immune rejection, and supports the delivery of therapeutic cells in transplantation.

5. Precision Enzymology

The compound serves as a critical substrate in precision enzymology studies. Researchers use it to examine the activity of sialyltransferases, sialidases, and related enzymes. Its defined structure enables kinetic studies and aids in designing enzyme inhibitors for therapeutic applications.

6. Biomaterials and Tissue Engineering

Due to its hydrophilic and biocompatible profile, Colominic Acid Sodium Salt is incorporated into hydrogels, scaffolds, and biopolymers. It improves cell compatibility and hydration, supporting applications in regenerative medicine. Researchers use it to design advanced biomaterials for wound healing, cartilage repair, and artificial tissue development.

7. Carbohydrate and Glycobiology Research

Colominic Acid Sodium Salt serves as a reference standard and functional reagent in glycobiology. It is used for analyzing carbohydrate–protein interactions, enzymatic activity of sialidases, and metabolic labeling. This compound is critical for glycomics studies, enabling precise characterization of sialylated structures.

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What is Colominic acid sodium salt?

Colominic acid sodium salt is a naturally occurring polysialic acid derivative widely used in biochemistry and microbiology research, particularly in studying bacterial cell surfaces and immune interactions.

1/9/2010

Is Colominic acid sodium salt soluble in water?

Yes, it readily dissolves in water, making it convenient for cell culture and biochemical assays.

Is it safe to use in laboratory settings?

Yes, when handled with standard laboratory protective equipment. It is intended for research use only and not for human consumption.

"Reliable polysialic acid derivative with excellent consistency for biomedical applications."

Dr. Emily Roberts, Senior Research Scientist, University-Affiliated Medical Research Institute "As a biochemist working in a medical research institute, I found Colominic Acid Sodium Salt extremely valuable in glycoprotein and immunology studies. Its reproducible purity enhanced our ability to investigate cell-surface interactions with confidence."

7/1/2018

1. Separation of natural and synthetic heparin fragments by high-performance capillary electrophoresis
J B Damm, G T Overklift, B W Vermeulen, C F Fluitsma, G W van Dedem J Chromatogr . 1992 Sep 11;608(1-2):297-309. doi: 10.1016/0021-9673(92)87136-v.
The application of capillary electrophoresis (CE) for the analysis of natural and synthetic low-molecular-mass heparin fragments at low pH is described. It is demonstrated that under the applied conditions the separation is based on charge, charge distribution and molecular mass of the heparin molecules, yielding a high resolution. It is shown that the presence of sodium chloride in the sample solution has hardly any effect on the CE performance. However, the pH of the electrophoresis buffer is a critical parameter. The resolutions obtained with CE and high-performance anion-exchange chromatography (HPAEC) are compared for various heparin fragments and it is concluded that, at least for this type of molecule, CE forms an attractive alternative to HPAEC.
2. Purification and partial characterization of neuraminidase from type III group B streptococci
S J Mattingly, T W Milligan, D C Straus J Bacteriol . 1980 Oct;144(1):164-71. doi: 10.1128/jb.144.1.164-171.1980.
Extracellular neuraminidase from a type III fresh clinical isolate of a group B streptococcus was purified by a combination of salt fractionation, affinity chromatography of Affi-Gel blue, ion-exchange chromatography on diethylaminoethylcellulose, and gel filtration on Sephacryl S-200. These procedures yielded enzyme which was purified approximately 1,000-fold compared with the enzyme found in the original supernatant fluid. This type III streptococcal neuraminidase had a molecular weight of approximately 125,000 as estimated by filtration on Sephacryl S-200 and approximately 106,000 when analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In contrast to the majority of other bacterial neuraminidases, the type III group B streptococcal enzyme had no effect on colominic acid or N-acetylneuramin-lactose; however, it was quite active on bovine submaxillary mucin.

Production Advantages of Our Colominic Acid Sodium Salt

Scalable Production Capacity: We can reliably supply at the gram scale, with pilot-scale production reaching several hundred grams.

Injection-Grade Raw Material: Our product is manufactured to meet injection-grade standards, making it suitable for high-purity biomedical and pharmaceutical applications.

Endotoxin Control: Endotoxin levels are consistently held below 0.5 EU/mg, and we can tighten the limit even further upon request, ensuring maximum safety for sensitive research and clinical use.

Molecular Weight Customization: Our proprietary RAFT and NMP polymerization technologies enable gram-scale, batch-to-batch control of molecular weight ranges with ≤5 % polydispersity, meeting any application requirement.

About Us

BOC Sciences is a trusted global supplier of research chemicals, biochemicals, and pharmaceutical ingredients, serving the life sciences, biotech, and pharmaceutical industries. Headquartered in New York, we offer a comprehensive product portfolio that includes inhibitors, building blocks, carbohydrates, nucleosides, nucleotides, GMP products, impurities and metabolites, APIs, natural compounds, ADC-related chemicals, and stem cell molecules.

We specialize in the synthesis, biosynthesis, purification, and characterization of small molecules. With years of industry experience, our scientific and technical teams support projects ranging from early discovery to process development and regulatory submission.

BOC Sciences operates GMP-compliant and ISO-certified production facilities, ensuring consistent quality and regulatory alignment. Our products and services are trusted by clients in over 60+ countries, including top pharmaceutical companies, academic institutions, and research organizations.

We are committed to providing high-quality chemicals, responsive technical support, and flexible custom solutions to accelerate innovation in drug discovery and development.

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