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Butoconazole
Butoconazole Chemical Structure

Butoconazole

Catalog NO.: 64872-76-0 CAS NO.: 64872-76-0 Brand: BOC Sciences

Category
APIs
Tag
Generic APIs
Molecular Formula
C19H17Cl3N2S
Molecular Weight
411.78

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cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
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Product Description

Butoconazole (trade names Gynazole-1, Mycelex-3) is an imidazole antifungal used in gynecology, which is effective as therapy for vulvovaginal candidiasis for women who prefer solid-type vaginal preparations. It is administered as a vaginal cream.

InChI Key
SWLMUYACZKCSHZ-UHFFFAOYSA-N
InChI
InChI=1S/C19H17Cl3N2S/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22/h1-5,7-8,10-11,13,16H,6,9,12H2
SMILES
ClC1=C(SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(Cl)=CC=C1
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1.[Gynazol for treatment of vulvo-vaginal candidiasis--our experience].
Rachev E. Akush Ginekol (Sofiia). 2007;46(2):25-7.
OBJECTIVE: to have a personal experience concerning the therapeutic characteristics of the new product GYNAZOL (Gedeon Richter, Ltd)--5 g. vaginal cream for treatment of vulvo-vaginal candidosis (VVC).
2.[The statement of Polish Gynecological Society Experts on the treatment of acute vulvovaginal candidiasis with prolonged releasing 2% butoconazole nitrate vaginal cream--state of art in 2008].
Expert Board of Polish Gynecological Society. Ginekol Pol. 2009 Apr;80(4):303-11.
Vulvovaginal infection is the most common cause of gynecological problems in sexually active women. Knowledge about pharmacological properties of drugs used in treatment vulvovaginal candidiasis allows for tailoring therapy to each patient. 2% butoconazole nitrate vaginal cream is modern and up to date option for treatment of acute vulvovaginal candidiasis. Short- and long-term therapeutic efficacy of butoconazole vaginal cream was confirmed in numerous high reliability clinical trials. Good tolerance, high effectiveness of single therapeutic dose and high level of patient's acceptance gives the specialist powerful and efficient tool for management of VVC.
3.[Treatment in cases of recurrent vaginal candida infection during pregnancy].
Nikolov A, Shopova E, Mikhova M, Dimitrov A. Akush Ginekol (Sofiia). 2007;46(9):23-6.
OBJECTIVE: To study the therapeutic application of Gynazol in cases of recurrent vaginal Candida infections during the last trimester of pregnancy.
4.Anti-inflammatory and anti-itch activity of sertaconazole nitrate.
Liebel F1, Lyte P, Garay M, Babad J, Southall MD. Arch Dermatol Res. 2006 Sep;298(4):191-9. Epub 2006 Jul 26.
Cutaneous fungal infections are frequently associated with an inflammatory component including irritated skin, itching and stinging/burning. Therapeutic anti-fungal agents that have anti-inflammatory activity have the potential to provide clinical benefit beyond fungus eradication. Recently, certain anti-fungal agents have been shown to have intrinsic anti-inflammatory activity, therefore we sought to determine the extent of the anti-inflammatory activity of these compounds. The anti-inflammatory activities of eight anti-fungal agents (butoconazole, ciclopirox olamine, fluconazole, miconazole nitrate, sertaconazole nitrate, terconazole, tioconazole and ketoconazole) were compared in a number of preclinical models of dermal inflammation and pruritus. While butoconazole, ciclopirox olamine, fluconazole, and miconazole nitrate were all found to have anti-inflammatory activity, only sertaconazole nitrate reduced the release of cytokines from activated lymphocytes and mitigated inflammation in animal models of irritant contact dermatitis and neurogenic inflammation.
Preparing Stock Solutions
ConcentrationVolumeMass1 mg5 mg10 mg
1 mM2.4285 mL12.1424 mL24.2848 mL
5 mM0.4857 mL2.4285 mL4.8570 mL
10 mM0.2428 mL1.2142 mL2.4285 mL
50 mM0.0486 mL0.2428 mL0.4857 mL
About Us

BOC Sciences is a trusted global supplier of research chemicals, biochemicals, and pharmaceutical ingredients, serving the life sciences, biotech, and pharmaceutical industries. Headquartered in New York, we offer a comprehensive product portfolio that includes inhibitors, building blocks, carbohydrates, nucleosides, nucleotides, GMP products, impurities and metabolites, APIs, natural compounds, ADC-related chemicals, and stem cell molecules.

We specialize in the synthesis, biosynthesis, purification, and characterization of small molecules. With years of industry experience, our scientific and technical teams support projects ranging from early discovery to process development and regulatory submission.

BOC Sciences operates GMP-compliant and ISO-certified production facilities, ensuring consistent quality and regulatory alignment. Our products and services are trusted by clients in over 60+ countries, including top pharmaceutical companies, academic institutions, and research organizations.

We are committed to providing high-quality chemicals, responsive technical support, and flexible custom solutions to accelerate innovation in drug discovery and development.

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