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  7. NADH (disodium salt)
NADH (disodium salt)
NADH (disodium salt) Chemical Structure

NADH (disodium salt)

Catalog NO.: B0084-095443 CAS NO.: 606-68-8 Brand: BOC Sciences

Category
Carbohydrates, Nucleosides & Nucleotides
Structure/Application
Dinucleoside Polyphosphates
Molecular Formula
C21H27N7Na2O14P2
Molecular Weight
709.41
Size Price Stock Quantity
1 g $285 In stock

Request another packsize? Click Bulk Order.

cGMP Capacity

  • kg to MT scale
  • GMP batches production
  • Over 20 years of experience
  • HPAPI production with OEL < 1 μg/m³
  • Cleanroom Class 100 to Class 100,000
  • Special type of reactions in cGMP workshop
  • Cleaning level: Class A B C
  • cGMP synthesis workshop
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Product Description

NADH becomes oxidized to produce NAD+, NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain.
Nutritional supplement in health care products.

Quantity
Grams-Kilos
Melting Point
>188 °C
InChI Key
QRGNQKGQENGQSE-WUEGHLCSSA-L
InChI
1S/C21H29N7O14P2.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;/q;2*+
SMILES
C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=NC5=C4N=CN=C5N)O)O)O)O.[Na+].[Na+]
Stability
Stable. Incompatible with strong oxidizing agents.
Write a review Ask a question

Could you please give me some information of the activity of NADH (disodium salt) in vivo?

NADH (disodium salt) promotes alcohol metabolism and prevents or improves early liver injury induced by acute alcohol exposure in ethanol-loaded mice.

29/12/2016

Excuse me, is the stability of NADH (disodium salt) good?

NADH (disodium salt) is unstable under acidic conditions, but stable under alkaline conditions.

29/12/2016

In which energy metabolic processes does NADH (disodium salt) play a role?

NADH (disodium salt) plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.

29/12/2016

increase the level of NAD+

In my lab, NADH (disodium salt) performed well at increasing the level of NAD+ in various mammalian cell lines.

28/3/2018

protect cells from genotoxicity

I'm satisfied with that NADH (disodium salt) has low toxicity and protects cells from genotoxicity.

28/3/2018

1.Enzymatic reduction of complex redox dyes using NADH-dependent reductase from Bacillus subtilis coupled with cofactor regeneration.
Bozic M1, Pricelius S, Guebitz GM, Kokol V. Appl Microbiol Biotechnol. 2010 Jan;85(3):563-71. doi: 10.1007/s00253-009-2164-8. Epub 2009 Aug 7.
Conventional vat dyeing involves chemical reduction of dyes into their water-soluble leuco form generating considerable amounts of toxic chemicals in effluents. In the present study, a new beta-nicotinamide adenine dinucleotide disodium salt (NADH)-dependent reductase isolated from Bacillus subtilis was used to reduce the redox dyes CI Acid Blue 74, CI Natural Orange 6, and CI Vat Blue 1 into their water-soluble leuco form. Enzymatic reduction was optimized in relation to pH and temperature conditions. The reductase was able to reduce Acid Blue 74 and Natural Orange 6 in the presence of the stoichiometrically consumed cofactor NADH; meanwhile, Vat Blue 1 required the presence of mediator 1,8-dihydroxyanthraquinone. Oxygen from air was used to reoxidize the dyes into their initial forms. The enzymatic reduction of the dyes was studied and the kinetic constants determined, and these were compared to the chemically-reduced leuco form. The enzyme responsible for the reduction showed homology to a NADH-dependent reductase from B.
2.Effects of activating cations and inhibitor on the allosteric regulation of rabbit muscle pyruvate kinase.
Li F1, Yu T, Jiang H, Yu S. Int J Biol Macromol. 2013 Sep;60:219-25. doi: 10.1016/j.ijbiomac.2013.05.028. Epub 2013 Jun 5.
Rabbit muscle pyruvate kinase (RMPK) requires activating cations for activity, but its activity can be allosterically inhibited. In this study, isothermal titration calorimetry (ITC) was used to examine the different effects of activating cations (K(+) or Mg(2+)) and inhibitor (Phe) on the allosteric regulation of RMPK. The ITC data reveal that the enthalpy change was greater for PEP binding to the active state compared to the inactive state. Meanwhile, the percentage of the active state increased with increasing concentration of K(+) or Mg(2+), whereas increasing Phe concentration had the opposite effect. In addition, we hypothesize that the activation of RMPK involves two processes. First, the interaction of Mg(2+) leads to a more exposed active site of RMPK. The process is rapid and only a small quantity of Mg(2+) can make RMPK transform to the intermediate state. Second, the subsequent binding of K(+) causes a critical orientation of the active site, which plays a more decisive role for PEP binding to RMPK than Mg(2+).
3.Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway.
Wang PR1, Wang JS, Zhang C, Song XF, Tian N, Kong LY. J Ethnopharmacol. 2013 Aug 26;149(1):270-80. doi: 10.1016/j.jep.2013.06.035. Epub 2013 Jun 28.
ETHNOPHARMACOLOGICAL RELEVANCE: Huang-Lian-Jie-Du-Decotion (HLJDD, Hwangryun-Hae-Dok-Decotion in Japan), an ancient antipyretic and detoxifying traditional Chinese medicine formula, was reported to have protective effect on ischemic stroke.
4.DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite.
Watanabe C1, Egami T, Midorikawa K, Hiraku Y, Oikawa S, Kawanishi S, Murata M. Environ Health Prev Med. 2010 Sep;15(5):319-26. doi: 10.1007/s12199-010-0146-1. Epub 2010 Apr 28.
OBJECTIVES: The environmental pollutant 2-nitrotoluene (2-NO(2)-T) is carcinogenic and reproductively toxic in animals. In this study, we elucidated the mechanisms of its carcinogenicity and reproductive toxicity.
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