BOC Sciences Blog

The Latest Developments in ADC Payloads

The Latest Developments in ADC Payloads

Driven by increasingly mature technologies, ADC payloads have undergone three generations of innovation. In the first generation of ADC drugs, traditional chemotherapy agents such as methotrexate, vincristine, and doxorubicin were used […]

The Magical Biotin

The Magical Biotin

What is Biotin? Biotin, with a molecular weight of 244.31, consists of two cyclic structures. The first ring is the imidazolone ring, the primary site for binding with avidin; the […]

Comparison and Analysis of SMDC, ADC, and DAC

Comparison and Analysis of SMDC, ADC, and DAC

In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the […]

Preparation Methods of Microspheres

Preparation Methods of Microspheres

There are various techniques for the preparation of microspheres, and the selection of an appropriate method depends on the physicochemical properties of the drug. Currently, the most widely used methods […]

ADCs

Several Ways of Thiol Coupling in ADCs

The popularity of thiol coupling in ADC preparation can be attributed to three factors: It is essential to note that a reduction step is always required before coupling to release […]

What is Peptide Nucleic Acid (PNA)?

What is Peptide Nucleic Acid (PNA)?

Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. […]

General Design Methods for mRNA Drugs

General Design Methods for mRNA Drugs

With the rapid development of biotechnology and molecular medicine, the introduction of mRNA as a vaccine or therapeutic agent enables the production of almost any desired functional protein/peptide within the […]

Clinical Prospects of Aptamer Applications

Clinical Prospects of Aptamer Applications

Aptamers are short RNA/DNA oligonucleotide molecules that bind specifically to complementary target molecules. As potential recognition elements, aptamers show promising applications in both diagnosis and treatment. They offer diverse therapeutic and diagnostic […]

CD137/4-1BB combination therapy

Two Paths of Second-Generation 4-1BB Agonists

CD137/4-1BB combination therapy

Hypoglycemic Functional Factors in Natural Products and Their Mechanisms of Action

Hypoglycemic Functional Factors in Natural Products and Their Mechanisms of Action

Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of […]