The target spectrum and treatable diseases of small nucleic acid drugs are diverse. Relevant companies primarily focus on rare monogenic diseases with clear pathogenic mechanisms, well-defined biomarkers, and a lack […]
Molecular Glue refers to small molecules, typically smaller than PROTACs, often with improved physicochemical properties, designed to stabilize interactions between two proteins. In most cases, this approach is used to enhance […]
In the process of small molecule drug development, lipophilicity (or hydrophobicity) is a very important indicator that has a crucial impact on pharmacokinetics and pharmacodynamics. Lipophilicity involves the pharmacokinetic processes […]
mRNA therapeutics is a newly emerging form in recent years. Its basic principle is to introduce mRNA expressing antigen targets into the body through specific delivery systems, express protein antigens […]
Protein homeostasis refers to the balance of proteins within cells, involving processes such as protein synthesis, folding, modification, transport, function, and degradation. Proteins in cells participate in nearly all life […]
The preparation of amides is one of the most common reactions in organic synthesis and a key reaction for the preparation of peptide drugs and nucleic acid drugs in recent years. […]
The Drug-to-Antibody Ratio (DAR) is the most important quality attribute of ADC drugs because it determines the “payload” that can be delivered to tumors, directly impacting safety and efficacy. Here, we […]
In the early 21st century, after the completion of the Human Genome Project, it was discovered that many diseases were caused by gene mutations leading to insufficient expression of functional […]
Driven by increasingly mature technologies, ADC payloads have undergone three generations of innovation. In the first generation of ADC drugs, traditional chemotherapy agents such as methotrexate, vincristine, and doxorubicin were used […]
What is Biotin? Biotin, with a molecular weight of 244.31, consists of two cyclic structures. The first ring is the imidazolone ring, the primary site for binding with avidin; the […]