Antibody Drug Conjugates Services

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Antibody-drug conjugates (ADCs) are a very important class of highly potent drugs designed as a targeted therapy for the treatment of people who has cancer. It represents an innovative therapeutic application that includes the unique, high specificity and antitumor activity of monoclonal antibodies which are tumor-specific but not very cytotoxic, with the cell killing activity of small molecule drugs that are too toxic to be used on their own. Scientists could optimize the features of both components by linking monoclonal antibodies with cytotoxic agents.

BOC Sciences is the industry leading expert in small molecular and antibody engineering, also our rich experience could help us to provide comprehensive services for the conjugation and characterization of Antibody-Drug Conjugates. With years of experience in the variety of organic synthesis and binding assays, we provide comprehensive expertise to support the development of antibody-drug conjugate products for all phases of drug development from discovery to GMP manufacturing.

Antibody Drug Conjugates Services

As ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic (anticancer) payload or drug, an ideal ADC has:

  • • A highly selective monoclonal antibody for a tumor-associated antigen that has restricted or no expression on healthy cells;
  • • A potent cytotoxic small molecule drug designed to induce target cell death after being internalized in the tumor cell and released;
  • • A linker that is stable in circulation, but releases the cytotoxic agent in target cells.

BOC Sciences’ integrated capabilities for development of antibody-drug conjugates:

  • • Analytical method: HPLC, UPLC, LCMS, UV, FL, cSDS, cIEF, CZE, DSC, TGA, ELISA, DLS, HIAC;
  • • Synthesis and characterization of small molecule drugs;
  • • Conjugated antibodies, polymers, proteins and fluorophores;
  • • Biotin, ADC, Polymer–drug, Polymer-drug-target ligand conjugation;
  • • Drug substance characterization;
  • • Process development;
  • • Technology transfer;
  • • Analytical method development and validation.
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