Compared with conventional drugs, nucleic acids have great advantages. The mechanism of action and high specificity of nucleic acids provide possible therapeutic approaches for viral infections, various cancers and inoperable […]
Oligonucleotides are short synthetic DNA or RNA polymers, which modulate gene expression through Watson-Crick base pairing with targeted nucleic acids. Oligonucleotides regulate gene expression through a series of processes, including […]
Abstract Immunotherapy has become an indispensable part of cancer treatment. A pivotal phagocytosis checkpoint, named cluster of differentiation 47 (CD47), which functions as a ‘don’t eat me’ signal to protect […]
The development of antibody-drug conjugates (ADCs) has progressed significantly over the past decade due to improvements in payloads, linkers, and conjugation methods. In particular, linker design plays a key role […]
Introduction of Vaccine Adjuvant Adjuvant, also known as immune modulator or Immunepotentiator, is an additive of vaccine. When injected into the body before or mixed with antigen, it can enhance […]
The parent skeleton of Dipyrromethene Boron Difluoride (BODIPY) is a large rigid planar structure, which is composed of two pyrrole rings and a six membered boron nitrogen heterocycle. Because of […]
Drug Modification Drug modification involves altering the chemical structure of the drug itself (such as functional groups, amino acids or nucleic acid skeletons) and coupling the drug with known partial […]
Introduction of IAP Apoptosis, or programmed death, is a natural cell cycle process designed to eliminate unwanted or damaged cells from the body. In healthy tissues, there is a good […]
Kinases have become an extremely important molecular target for a range of therapeutic targets. The kinase inhibitors are a large group of unique and potent antineoplastic agents which specifically target […]
Proteasome is the main pathway by which misfolded proteins and other proteins are proteolyzed during protein synthesis. It is found in all eukaryotic cells, archaea and some bacteria and is […]