Beta Cyclodextrin Derivatives as Protein Aggregation Modulators

Popescu, C., Miles Larson, N. M., Hong, S., & Nayar, R.

Protein aggregation is the major challenge encountered during manufacturing, storage and transportation of biopharmaceuticals (1, 2). Our objective was to evaluate the effect of twoßcyclodextrins derivatives: (KLEPTOSE® HPB hydroxypropyl-ß-cyclodextrin, with MS=0.65) and (KLEPTOSE® HP hydroxypropyl-ß-cyclodextrin, with MS=0.9) on two biologic drugs (Infliximab and Etanercept) aggregation using high-throughput formulation screening (iFormulate) and nanoDSF (Differential Scanning Fluorimetry) (3, 4).

Beta-Cyclodextrin-Derivatives-as-Protein-Aggregation-Modulators

Products Used in this Publication

Dimeric fusion protein

Related Products

Catalog NumberCASProduct NamePrice
B0084-0073851448189-80-7Protein degrader 1 hydrochlorideInquiry
B0001-1498097161-73-1Thiocholine iodideInquiry
B0001-16063111096-26-7ErythropoietinInquiry
B0001-186805203787-91-1Salcaprozate sodium, 99%Inquiry
B0001-3946391341-23-7Nicotinamide Riboside (Contain ~80% food grade dextrin as stabilizer)Inquiry