The protein-DNA interaction is of great importance for many cellular functions such as replication, transcription, cell cycle progression, recombination, DNA repair, genomic stability, and epigenetic silencing. Chromatin immunoprecipitation (ChIP) is one of the most valuable experimental technique used to investigate the protein-DNA interaction and the chromatin organization at the cellular level. It aims to determine whether the target proteins are associated with specific DNA locus in the cells, and also provide the information of distribution of the target protein or modified histone in the whole genome. The workflow of ChIP assy is shown as below:
Application of CHIP Assays Service
CHIP is a common method to study transcription factor binding sites or protein modification sites. With the development of NGS, chromatin immunoprecipitation sequencing (CHIP-Seq), which combines CHIP and NGS, can now efficiently and accurately screen and identify protein binding sites on the whole chromosome. CHIP also aims to determine the specific location of various histone modifications in the genome and to indicate the goal of histone modification.
BOC Sciences is the leading industry in chemical ligands, antibody engineering and cellular technologies, providing package services for comprehensive experimental design, operation and data analysis in ChIP assay. Below is a list of our services (including but not limit following):
Why choose BOC Sciences?
BOC Sciences is a professional ChIP service provider that provides comprehensive ChIP solutions. You can simply provide us with samples of your cells or tissues. Our scientists team with over a decade of experience in molecular biology and cellular biology will facilitate your research or industrial projects on drug discovery and molecular mechanism based on protein-DNA interaction.
GeneReader NGS system