Combination therapy to treat Mycobacterium diseases

Locher, C. P., Bennani, Y. L., Grillot, A. L., O'dowd, H., Perola, E., Le Tiran, A., & Charifson, P. S.

U.S. Patent No. 9,572,809. 21 Feb. 2017.

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.


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