Beta Cyclodextrin Derivatives as Protein Aggregation Modulators

Popescu, C., Miles Larson, N. M., Hong, S., & Nayar, R.

Protein aggregation is the major challenge encountered during manufacturing, storage and transportation of biopharmaceuticals (1, 2). Our objective was to evaluate the effect of twoßcyclodextrins derivatives: (KLEPTOSE® HPB hydroxypropyl-ß-cyclodextrin, with MS=0.65) and (KLEPTOSE® HP hydroxypropyl-ß-cyclodextrin, with MS=0.9) on two biologic drugs (Infliximab and Etanercept) aggregation using high-throughput formulation screening (iFormulate) and nanoDSF (Differential Scanning Fluorimetry) (3, 4).

Beta-Cyclodextrin-Derivatives-as-Protein-Aggregation-Modulators

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Dimeric fusion protein

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