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Design and Synthesisof Gramicidin S Analogs with High Antibiotic Activity

Design and Synthesisof Gramicidin S Analogs with High Antibiotic Activity

N-(2,4-Dinitrophenyl)tetrapeptide p-nitroanilides (Dnp-tetra-peptide-pNA) exhibit characteristic CD spectra when they take on β-turn conformation. Exciton coupling of electric transition dipoles of the two chromophores is thought to be the origin of […]

Preclinical Studies on the Pharmacokinetics, Safety, and Toxicology of Oxfendazole: Toward First in Human Studies

Preclinical Studies on the Pharmacokinetics, Safety, and Toxicology of Oxfendazole: Toward First in Human Studies

A number of BZ anthelmintics used in veterinary medicine have been considered for transition to human use, including oxibendazole and oxfendazole (OXF). In addition, flubendazole, already approved for use as […]

First report of fluazuron resistance in Rhipicephalus microplus: A field tick population resistant to six classes of acaricides

First report of fluazuron resistance in Rhipicephalus microplus: A field tick population resistant to six classes of acaricides

João Ricardo de Souza Martins and co-workers described the first report of fluazuron resistance in R. microplus, and also report the first tick strain that was multi-resistant to six classes […]

Development of albendazole sulfoxide-loaded Eudragit microparticles: A potential strategy to improve the drug bioavailability

Development of albendazole sulfoxide-loaded Eudragit microparticles: A potential strategy to improve the drug bioavailability

Benzimidazole compounds are especially effective against nematodes found in the gastrointestinal tube in combating adult worms besides their larvae and eggs. They are also highly effective against lung worms. Their […]

Role of excipients in the crystallization of Albendazole Has Been Reported

Role of excipients in the crystallization of Albendazole Has Been Reported

Mihir K. Raval and coworkers reported cocrystallization of Albendazole. Cocrystallization approach with solvent evaporation technique at room temperature has been utilized to improve the physicochemical and mechanical properties of albendazole […]

Breakdown of Phosphatidylserine Asymmetry Following Treatment of Erythrocytes with Lumefantrine

Breakdown of Phosphatidylserine Asymmetry Following Treatment of Erythrocytes with Lumefantrine

Background: Lumefantrine, a commonly used antimalarial drug, inhibits hemozoin formation in parasites. Several other antimalarial substances counteract parasitemia by triggering suicidal death or eryptosis of infected erythrocytes. Eryptosis is characterized […]

Total synthesis of avermectin B1a revisited

Total synthesis of avermectin B1a revisited

Total synthesis of avermectin B1a revisited was achieved by Masahiro Hirama and co-workers in Tohoku University in Japan. Avermectins were isolated as compounds possessing anthelmintic activity from the culture broth of Streptomycesavermitilis by Ōmura […]

Cells in Senescence State May Help Slow down Aging and Cancer Treatment

Cells in Senescence State May Help Slow down Aging and Cancer Treatment

Cell senescence means a state where cells stop further development in their function but clean themselves and remove the extra substance. Scientists found that when cells go into this stage, […]

Collection of Nobel Prize Female Winners in Sciences Chapter II

Collection of Nobel Prize Female Winners in Sciences Chapter II

The last chapter briefly introduced the female scientists of Nobel Prize in physics and chemistry the two aspects, this post will make a rough description of the rest 10 women who […]

Peptides Produced by Gut Bacteria Could Hinder the Development of Type 1 Diabetes

Peptides Produced by Gut Bacteria Could Hinder the Development of Type 1 Diabetes

Studies have found that peptides produced by a certain type of gut bacteria can be used to prevent type 1 diabetes from deteriorating and the lack of such gut bacteria […]