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Ten Facts That You May not Know about Pregnancy (part two)

Ten Facts That You May not Know about Pregnancy (part two)

6. Is it safe to use metformin safe during pregnancy? Metformin has long been regarded as an ideal choice for TypeⅡ diabetes treatment due to its effectiveness, but the question arises […]

Human herpes virus

Human herpes virus

Herpes is an extremely common virus infection able to cause a recurrent skin infection that can appear in its different types as small blisters on the genitals or as cold […]

The Source and Effect of Ginsenosides

The Source and Effect of Ginsenosides

Ginseng is any of eleven different varieties of short, slow growing perennial plants with fleshy roots. Ginseng is believed to restore and enhance normal well-being and has become one of […]

Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery

Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery

In recent years, significant efforts have been devoted to the development of amphiphilic polymers consisting of hydrophilic polysaccharides and hydrophobic moieties because of their ability to form nanoparticle self-assemblies in […]

Comparison of the Pharmacokinetics of Albendazole and its Major Metabolites after Oral Administration of Albendazole as a Suspension and as a Paste Formulation to Sheep

Comparison of the Pharmacokinetics of Albendazole and its Major Metabolites after Oral Administration of Albendazole as a Suspension and as a Paste Formulation to Sheep

Albendazole is a member of the benzimidazole group of anthelmintics with broad-spectrum activity against gastro-intestinal roundworms including inhibited larval stages, tapeworms, liver flukes and lungworms in many species. In the […]

Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists

Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists

The vertebrate orexin neuropeptide–receptor system plays a pivotal role in the regulation of sleep and wake states as well as emotional states related to stress or reward. The neuropeptides orexin […]

Small-molecule modulators of the Sonic Hedgehog signaling pathway

Small-molecule modulators of the Sonic Hedgehog signaling pathway

Small-molecule modulators of the Sonic Hedgehog signaling pathway Shh pathway inhibition with non-naturally occurring small molecules Cell-based assays with reporter gene constructs have been widely used for discovering non-naturally occurring […]

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

The ADP-ribosyltranferase diphtheria toxin-like (ARTD) or poly-ADP-ribose polymerase (PARP) protein superfamily comprises 17 proteins that contain a common catalytic domain. Those that are catalytically active use β-NAD+ as an essential […]

HPLC-DAD-MSn analysis and HPLC quantitation of chemical constituents in the traditional Chinese medicine formula Ya-tong-yi-li-wan

HPLC-DAD-MSn analysis and HPLC quantitation of chemical constituents in the traditional Chinese medicine formula Ya-tong-yi-li-wan

Ya-tong-yi-li-wan (YTYLW) is a well-known traditional Chinese medicine (TCM) formula composed of ChanSu (toad venom), licorice root, realgar, and cinnabaris in the ratio of 24 : 24 : 6 : […]

Recent advances in the synthesis of new glycopeptide antibiotics

Recent advances in the synthesis of new glycopeptide antibiotics

  Semi-synthetic glycopeptide antibiotics   Oritavancin, telavancin and dalbavancin   Early studies by Nagarajan et al. into the development of semi-synthetic glycopeptide antibiotics focused on utilizing vancomycin as a structural […]