2-Mercaptobenzoimidazoles are an interesting class of heterocycles in medicinal chemistry as their core structure is part of different established therapeutics. The most prominent ones of these drugs are omeprazole, which acts as […]
In highly lipogenic tissues such as the liver, adipose and lactating breast, the Fatty acid synthase (FAS) catalyzed fatty acid synthesis pathway has three main functions: 1) the conversion of excess caloric intake […]
Converging evidence from numerous investigations suggests that the role of corticotropin-releasing factor (CRF) in modulating the neurobiological effects of ethanol is dependent on the duration of exposure. Generally, initial or acute exposures […]
Biologics have changed the landscape of therapy for rheumatoid arthritis (RA). While they have substantially improved outcomes in patients with RA who are disease-modifying antirheumatic drug (DMARD) incomplete responders (IRs), they require administration via […]