The presence of amyloid deposits in the brain is one of the major histopathological characteristics of Alzheimer’s disease (AD). The amyloid cascade hypothesis proposes that the amyloid -peptide (Aβ), a major component […]
The “cholinergic hypothesis” proposes that part of age-related cognitive decline is caused by reduced cerebral cholinergic function. This theory has been used as a rationale for testing drug therapies that restore cholinergic function […]
Endothelium derived relaxant factors (EDRFs) Endothelium derived relaxant factor is produced and released by the endothelium to cause smooth muscle relaxation. The characterized EDRFs include nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived […]
Diabetes mellitus (DM), commonly referred to as diabetes, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar) levels over a prolonged period, either […]