Delivering therapeutic agents to the heart has long been a formidable challenge. While cardiovascular diseases remain the world’s leading cause of mortality, modern therapeutic strategies—including RNA medicines, protein drugs, and […]
Engineering the Future of Sustainable Bioproduction with BOC Sciences The growing need for sustainable and efficient production systems has positioned microbial engineering and synthetic biology at the forefront of the […]
Introduction: The Next Frontier of Lipid Nanoparticles (LNPs) in Cancer Nanomedicine For decades, cancer nanomedicine has pursued a central goal — to deliver potent therapies directly to tumors while sparing healthy […]
The Rising Global Demand for GLP-1 Therapies As global rates of diabetes and obesity continue to climb, GLP-1 receptor agonists (GLP-1 RAs) have attracted tremendous attention for their remarkable glucose-lowering and […]
Hyperlipidemia is one of the most significant controllable risk factors for cardiovascular and cerebrovascular diseases such as myocardial infarction and stroke. These conditions have long ranked among the leading causes […]
A very high proportion of approved drugs contain nitrogen-containing heterocyclic structures. Taking the period from 2013 to 2023 (11 years) as an example, 82% of all approved drugs featured at […]
Transfer RNA-derived small RNAs (tsRNAs) are a class of small non-coding RNAs (sncRNAs) generated from precursor or mature tRNAs through specific cleavage by ribonucleases such as Angiogenin (ANG), Dicer, and […]
Technology Overview Aptamer-ASO chimeras are innovative bifunctional oligonucleotide therapeutics that combine the high-affinity targeting of aptamers with the gene-silencing capabilities of antisense oligonucleotides (ASOs) [1]. This hybrid design enables precise delivery […]
Introduction to GalNAc-ASO Technology GalNAc (N-acetylgalactosamine)-conjugated antisense oligonucleotides (ASOs) utilize triantennary GalNAc ligands to bind the asialoglycoprotein receptor (ASGPR) on hepatocytes. This enables receptor-mediated endocytosis, delivering ASOs specifically to liver […]
Introduction Toll-like receptors (TLRs) play a crucial role in innate immunity by detecting foreign RNA and triggering immune responses. Among these, TLR7 and TLR8 recognize RNA degradation products in endolysosomal compartments, […]