Kinase inhibitors can be divided into monoclonal antibodies (mAbs) and small molecule kinase inhibitors (SMKIs) based on their structure and size. Monoclonal antibodies have achieved great success in the development […]
1. Structural Characteristics of PROTAC PROTAC consists mainly of three key structures: on one side is the ligand structure targeting the Protein of Interest (POI); on the other side is […]
Existing research shows that nucleic acids can be used for the treatment of neurological diseases, cardiovascular diseases, and cancer, as well as for the prevention of chronic and infectious diseases. […]
B7-H3 and B7-H4 are type I transmembrane proteins belonging to the B7 family. Their abnormal expression is associated with many diseases such as colon cancer, breast cancer, liver cancer, and […]
Introduction to HER and ADCs Members of the human epidermal growth factor receptor (HER) family, including HER1 (EGFR), HER2, HER3, and HER4, play a core role in regulating cell proliferation, […]
1. What is endotoxin? Endotoxin is a type of lipopolysaccharide (LPS) that originates from the outer membrane of Gram-negative bacteria. The outer lipid component of the cell wall is entirely […]
Pfizer’s mRNA vaccine for COVID has reignited the passion for using ribonucleic acid (RNA) as a therapeutic target. However, targeting RNA with small molecules is extremely challenging. RNA only has […]
The core technologies of oligonucleotide drug development include sequence design, synthesis and modification, isolation and purification, and delivery techniques. The production of oligonucleotide raw materials adopts solid-phase synthesis technology, with […]
Mechanisms of Immune Escape in Tumors Although the human immune system uses powerful immune cells and various immune measures, some immunogenic tumors evade clearance after initially being attacked by the […]
Purines are heterocyclic compounds composed of a pyrimidine ring and an imidazole ring and are the main components of nucleic acids. Their derivatives, such as adenine, guanine, and xanthine, are […]