BOC Sciences Blog

Anticholinergic Treatment in Airways Diseases

Anticholinergic Treatment in Airways Diseases

Acute and chronic airways diseases represent a large proportion of the inpatient and outpatient population continuously under the care of pulmonary physicians and primary healthcare providers. This review article aims […]

Pharmacokinetic properties and metabolism of idebenone

Pharmacokinetic properties and metabolism of idebenone

Idebenone (2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone) is a synthetic analogue of ubiquinone, an essential constituent of the electron transport chain and a vital cell membrane anti-oxidant. It has been shown that patients with Friedreich […]

Photoprotective effects of nicotinamide

Photoprotective effects of nicotinamide

In Australia, the lifetime risk of developing non-melanoma skin cancer such as basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) is almost 70% for men and 60% for women. […]

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2

Glioblastoma multiforme (GBM) is the most malignant primary human brain cancer and cannot be cured by any therapy available today. Current therapy includes complex treatments of neurosurgical resection, radiotherapy, and […]

The importance of impurity analysis in pharmaceutical products: an integrated approach

The importance of impurity analysis in pharmaceutical products: an integrated approach

Pharmaceutical industry is growing day by day with the aim to develop new drugs extracted from natural products or synthetic chemically produced drug substances, but one thing always remains constant, […]

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Pyrazinamide

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Pyrazinamide

A biowaiver monograph of pyrazinamide based on literature data together with some additional experimental data is presented. The risks of basing a bioequivalence (BE) assessment on in vitro rather than […]

Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

The study of carbamazepine solid forms continues to be a forum for advancing fundamental knowledge about polymorphism, hydrate formation, crystal engineering of pharmaceuticals, and structure–property relationships of pharmaceutical relevance. The […]

Progress in The Development of New Drugs in Alzheimer’s Disease

Progress in The Development of New Drugs in Alzheimer’s Disease

Alzheimer’s disease (AD) is an age-related neurodegenerative disease that is characterized by a progressive loss of memory associated with other cognitive sphere deficits interfering with social and occupational functioning. The […]

Roquinimex inhibits dextran sodium sulfate-induced murine colitis

Roquinimex inhibits dextran sodium sulfate-induced murine colitis

The majority of inflammatory bowel disease (IBD) consists of two related but clinically and histologically distinct conditions, ulcerative colitis and Crohn’s disease. Both conditions are characterized by chronically relapsing inflammation […]

Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery

Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery

In recent years, significant efforts have been devoted to the development of amphiphilic polymers consisting of hydrophilic polysaccharides and hydrophobic moieties because of their ability to form nanoparticle self-assemblies in […]