RAS is one of the most common oncogenes found in cancer patients, with RAS mutations detected in approximately 21% of all cancers. The RAS family comprises three subtypes: KRAS, NRAS, and […]
Definition The RAS-RAF-MEK-ERK signaling pathway is one of the most crucial intracellular signaling cascades and a key branch of the MAPK (Mitogen-Activated Protein Kinase) signaling pathway. This cascade transmits extracellular […]
In 1998, Andrew Fire and Craig Mello discovered the phenomenon of RNA interference (RNAi) in Caenorhabditis elegans, laying the foundation for the development of RNAi technology and earning them the […]
Antibody immobilization on the surface of a carrier is a critical step in the preparation of immunodiagnostic reagents. To enhance the detection limit and sensitivity of analytical methods, the application […]
In the field of biopharmaceuticals, the development of innovative drugs has always been a goal that scientists relentlessly pursue. With the continuous advancement of science and technology, a new drug […]
As of now, a total of 17 ADC drugs have been approved and marketed globally, among which 5 are conjugated via lysine residues. Product Name Company Target DAR Toxin Linker […]
cGAS/STING Innate Immune Signaling cGAS (cyclic GMP-AMP synthase) is a nucleotide transferase consisting of an unstructured, non-conserved N-terminal (130-150 residues) and a C-terminal containing an Mab21 domain and a highly […]
Protein-Protein Conjugation Methods Protein-protein conjugation is commonly used in immunoassays for enzyme-labeled antibodies or antigens, essentially preparing signal markers. The main protein-protein conjugation methods include the periodate oxidation method (direct […]
In recent years, with the continuous advancements in protein gene engineering and chemical conjugation technologies, the field of conjugated drugs has seen a blooming of diverse concepts, resulting in a […]
Chromatography is one of the most powerful techniques for protein purification. It allows for the separation of proteins based on their unique physicochemical properties. Here are the main types of […]