In 2007, Japanese professors firstly discovered ALK rearrangement and identified the fusion of ALK and EML4 in non-small cell lung cancer specimens. EML4 can promote the activation of ALK kinase […]
In 2001, the FDA approved Imatinib, the first drug to be developed by targeting a specific protein kinase and the first molecularly targeted drug to fight cancer. It was considered […]
Since the outbreak of COVID-19, the industry has reached a peak as terms such as “national nucleic acid test” has become increasingly popular and molecular diagnosis has been widely known […]
Pharmaceutical analysis and testing can study the composition, physical and chemical properties, authenticity, purity, and the content of active ingredients of drugs, which ensures that people can use drugs reasonably […]
CDKs belong to the serine/threonine protein kinase family, and their kinase activity requires binding to cyclins. Abnormalities in CDKs have been reported to cause proliferation, genomic and chromosomal instability that […]
MYC protein is an inherently disordered protein, which lacks a hydrophobic pocket or groove suitable for binding small molecule compounds. Currently, no small molecule compounds that can bind MYC have […]
Facing the Coronavirus with continuous mutations, researchers are working hard to develop effective and broad-spectrum anti-Coronavirus drugs and vaccines. At the end of 2021, the small molecule oral drug was […]
Since liposomes have a similar structure to cell membrane, they were used to study the structure and function of biofilms in the early stage. In the late 1960s, Rahman et […]
The Coronavirus outbreak has posed a great threat to human health. Facing the continuous mutation of Coronavirus, researchers are working hard to develop effective and broad-spectrum anti-COVID-19 drugs as well […]
Abnormally high expression of indoleamine 2, 3-dioxygenase 1 (IDO1) is closely related to tumor immune escape and is an important target of tumor immunotherapy. In-depth research on the structure and […]