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Total Synthesis of Distamycin A and 2640 Analogues: A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity

The regulation of gene expression is based on the sequence selective recognition of nucleic acids by a host of repressor, activator, and enhancer proteins. Selective external disruption or control of […]

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