Hot spots in the field of drugs in July


  • Nat Med: a special intestinal bacteria, which is expected to reduce the risk of cardiovascular disease by 50 percent of the population.

In 2007, scientists at institutions such as the University of Leuven found the beneficial effects of intestinal bacteria Akkermansia muciniphila, which may slow obesity and typeⅡdiabetes in mice, and compared with other intestinal flora, using the “pasteurized form” (inactivated form) of the bacteria can even better protect the body against a variety of cardiovascular disease risk factors, such as insulin tolerance, hypercholesterolemia or fat accumulation in adipose tissue. Based on the results of previous studies, researchers at institutions such as the University of Leuven recently conducted a clinical trial in which intestinal bacteria Akkermansia muciniphila were injected into the human body to observe their beneficial effects. In the article, the researchers injected Akkermansia into overweight or obese volunteers who showed insulin tolerance and metabolic syndrome. In other words, the volunteers were randomly divided into three groups: the comfort group, the live bacteria group and the pasteurization group. All the participants were asked not to change their eating habits and physical activity. Akkermansia was provided to participants as a nutritional supplement.

  • Nat Metabol: Human clinical trials have found that the compound Urolidine A in pomegranate does have an anti-aging effect!

Recently, in a study published in the international journal Nature Metabolism, scientists from institutions such as the Federal Institute of Technology in Lobsang, Switzerland, found that pomegranate and other fruits called Urolithin A may help slow down specific senescence processes by improving the function of cell mitochondria. In addition, ingestion of this compound has no risk to human health.

  • Cancer Cell: Through the super-activated cells in the “garbage disposal system” is expected to effectively kill cancer cells!

In a study published in the international journal Cancer Cell, scientists from the Light Source Research Center of the University of Saskatchewan have found a new way to kill leukemic cells. When the researchers hyperactivated (overactivated) the garbage disposal system in leukemic cells, the cancer cells were killed. Researcher Dr. In this study, researchers found that ONC201 can bind and hyperactivate ClipP protease to induce cancer cell death by the visualization of structural biology through crystallographic devices. The results of this study may help researchers to translate into cancer therapy through an in-depth study of specific proteins, which are potential targets for the development of new treatments.

  • BMC Cancer: scientists have identified two DNA secondary structures that may induce gene mutations that increase the risk of cancer.

Recently, a study published in the international journal BMC Cancer, scientists from the Russian University of higher Economic Research have identified two of the most common DNA structures: the stem-loops and the quadruplexes, these two structures can lead to genomic mutations that lead to cancer.

  • Sci Adv: Why are older people more likely to develop Alzheimer’s disease?

The risk of Alzheimer’s disease increases with age, according to a recent study published in the international journal Science Advances and they found that specific molecules called tau proteins are involved in the development of the disease.  Two different kinds of protein deposits in the brain are mainly involved in the occurrence of the disease. These two proteins, β-amyloid and tau neurofibrillary tangles, tau neurofibrillar tangles, can reflect the progress of the disease, which first appears in the memory center of the patient’s brain. It then occurs in other areas of the disease. Tau or tau protein aggregates move along nerve fibers, causing the disease to spread in the brain. Tau can spread rapidly in the aging brain.

  • Sci Adv: Moderate stress may make you live longer!

A description of what is called a chromatin structural defect, or chromatin pressure, triggers a response in cells that promotes longevity, a study published in the international journal Science Advances a few days ago. Researchers from Baylor Medical College and other institutions have found that moderate chromatin stress triggers stress responses in yeast, Cryptophthora elegans, Drosophila melanogaster, and mouse embryonic stem cells. In yeast and Cryptophthora elegans, this reaction can promote their longevity, and the results show that chromatin stress response and its mediated longevity may also exist in other organisms. This may provide researchers with new ideas to develop new strategies to intervene in human aging to promote longevity.

  • Science: Using a vaccine to enhance the efficacy of CAR-T cells in the treatment of solid tumors, 60% of solid tumors in mice can be completely eliminated.

A promising new way to treat certain types of cancer is to program the patient’s own T cells so that they can destroy cancer cells. This method, known as CAR-T cell therapy, is currently used to resist certain types of leukemia, but so far it has not been able to treat solid tumors, such as lung or breast tumors. Now, in a new study, researchers from the Massachusetts Institute of Technology have developed a new way to improve the treatment so that it can be used as a weapon against almost any type of cancer. Specifically, they developed a vaccine that significantly enhances the anti-tumor T-cell population and allows these T cells to invade solid tumors.

  • Diabetes Care: Diet and exercise may not reduce the risk of gestational diabetes in pregnant women!

In a recent study published in the international journal Diabetes Care, scientists from Vienna Medical University found that exercise and diet may not reduce the risk of gestational diabetes in pregnant women. Strict calorie restriction during pregnancy may have a very harmful effect on mothers and fetuses.

  • Nat Immunol: Although receiving ART treatment, there are still irreparable loopholes in the immune system of most HIV infected people.

CD4 T cells play a key role in coordinating immune response and are important leukocytes to control chronic infection such as HIV virus. On average, however, only about 1000 of the CD4 T-cell population can recognize the virus. Researcher Daniel Kaufmann said, “With the help of my team and partners, we identified all the genes expressed by these rare cells in the blood of patients with chronic HIV infection, in which, before receiving ART treatment, the virus is abundant in the blood. We then compared these cells with those from HIV controller, an HIV controller who without treatment was able to control the virus. This powerful method, also known as genome-wide transcriptional analysis, measures the activity of thousands of genes at one time, thus building global cell work.

  • Chem Sci: Scientists have successfully used bacterial homing to guide stem cells into the heart tissue to treat heart disease!

In a recent study published in the international journal Chemical Science, the University of Bristow developed for the first time in the world a new method of directing stem cells directly into heart tissue. This may be expected to fundamentally improve the treatment of patients with cardiovascular disease.