2016 April

Design and Synthesisof Gramicidin S Analogs with High Antibiotic Activity

Design and Synthesisof Gramicidin S Analogs with High Antibiotic Activity

N-(2,4-Dinitrophenyl)tetrapeptide p-nitroanilides (Dnp-tetra-peptide-pNA) exhibit characteristic CD spectra when they take on β-turn conformation. Exciton coupling of electric transition dipoles of the two chromophores is thought to be the origin of […]

Chemiluminescent detection systems of horseradish peroxidase employing nucleophilic acylation catalyst

Chemiluminescent detection systems of horseradish peroxidase employing nucleophilic acylation catalyst

The horseradish peroxidase (HRP)-catalyzed chemiluminescent oxidation of luminol is widely used in many molecular biology-based assays, such as Western blots, dot blots, and enzyme-linked immunosorbent assays (ELISAs), as well as […]

Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses

Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses

Favipiravir (T-705) is a nucleoside analog that was recently approved as an anti-influenza drug in Japan, and is in Phase 3 clinical trials in the USA for the same indication. […]