Research Hotspot

lab research

Emerging ADC Targets: B7-H3 and B7-H4

B7-H3 and B7-H4 are type I transmembrane proteins belonging to the B7 family. Their abnormal expression is associated with many diseases such as colon cancer, breast cancer, liver cancer, and […]

drugs

List of ADCs Targeting HER

Introduction to HER and ADCs Members of the human epidermal growth factor receptor (HER) family, including HER1 (EGFR), HER2, HER3, and HER4, play a core role in regulating cell proliferation, […]

Endotoxin

Fermentation and Purification Update: Endotoxin and Its Removal

1. What is endotoxin? Endotoxin is a type of lipopolysaccharide (LPS) that originates from the outer membrane of Gram-negative bacteria. The outer lipid component of the cell wall is entirely […]

drug discovery

The Forefront of Drug Discovery: Targeting RNA with Small Molecules

Pfizer’s mRNA vaccine for COVID has reignited the passion for using ribonucleic acid (RNA) as a therapeutic target. However, targeting RNA with small molecules is extremely challenging. RNA only has […]

Mechanisms of tumor immunity

Mechanisms of Tumor Immunity

Mechanisms of Immune Escape in Tumors Although the human immune system uses powerful immune cells and various immune measures, some immunogenic tumors evade clearance after initially being attacked by the […]

How to Make mRNA Vaccines in 18 Steps

How to Make mRNA Vaccines in 18 Steps

The launch of two mRNA vaccines in 2020 marked the formal entry of mRNA technology into the commercial era. Strong vaccine demand is expected to bring bright prospects to the entire […]

gene

Targeted Protein Degradation Technologies in the Treatment of Metabolic Diseases

Metabolic syndrome refers to a class of complex metabolic disorders, including adipose tissue accumulation, insulin resistance, diabetes, hyperinsulinemia, hypertension, and dyslipidemia, characterized by high levels of triglycerides (TG) and high-density […]

drug discovery

mRNA Drugs: Pros, Cons, and Prospects

Globally, the COVID-19 pandemic has significantly accelerated the development of mRNA technology platforms and mRNA industry chains. The first mRNA drug (BNT162b2 vaccine) was granted emergency use authorization by the […]

drug development

Casein Kinase 1 (CK1) Family as a Potential Therapeutic Target

CK1 functions Protein phosphorylation mediated by protein kinases is essential for the activation and deactivation of many signaling pathways in cells. As a result, abnormal protein kinase activity is frequently […]

Microglia Partner With T Cells To Cause Neurodegeneration, a New Nature Publication Discovers

Microglia Partner With T Cells To Cause Neurodegeneration, a New Nature Publication Discovers

Alzheimer’s disease (AD) is a complicated thing. Although amyloid-β (Aβ) is still considered to be the key to the pathogenesis of AD, which is supported by considerable evidence, the progression of […]