What are the methods of heating in an organic chemical reaction? Organic reactions are most commonly heated through the asbestos mesh and cannot be heated directly by fire. Otherwise, the instrument […]
Genotoxic impurities can directly act on DNA in the human body, causing DNA damage and having carcinogenic, teratogenic, or mutagenic properties. A small amount of genotoxic impurities can also cause great […]
The analysis of impurities in drugs is a very important part. This blog focuses on the important role of the source analysis of impurities and the development of analytical techniques in the […]
Overview of Suzuki coupling reaction In the entire Suzuki-coupling reaction cycle, the oxidation-addition reaction of Pd(0) with halogenated aromatics to produce the Pd(II) complex is considered to be the decisive […]
Summary Heterocyclic compounds with aromatic characteristics are called aromatic heterocyclic compounds, which can be classified into monoaromatic heterocycles and fused heterocycles. The common monoaromatic heterocycles are five-membered Furan, Pyrrole, Thiophene, Pyrazole, Imidazole, […]
Innovative drug research and development is a very complicated and risky process from discovery to marketing, which includes preclinical research, clinical trial application, clinical trial (also divided into clinical phases […]
CK1 functions Protein phosphorylation mediated by protein kinases is essential for the activation and deactivation of many signaling pathways in cells. As a result, abnormal protein kinase activity is frequently […]
Alzheimer’s disease (AD) is a complicated thing. Although amyloid-β (Aβ) is still considered to be the key to the pathogenesis of AD, which is supported by considerable evidence, the progression of […]
Targeted protein degradation (TPD) technology has been developed rapidly in recent years, especially proteolysis targeting chimeras (PROTACs). To date, a large number of degraders have been discovered against more than […]
Drug screening is the initial link and key to drug development. In the past, traditional drug screening methods such as animal models were often costly and time-consuming. With the development […]