Organic Synthesis

Monoaromatic Heterocyclic Chemistry: Applications and Synthesis

Monoaromatic Heterocyclic Chemistry: Applications and Synthesis

Summary Heterocyclic compounds with aromatic characteristics are called aromatic heterocyclic compounds, which can be classified into monoaromatic heterocycles and fused heterocycles. The common monoaromatic heterocycles are five-membered Furan, Pyrrole, Thiophene, Pyrazole, Imidazole, […]

Labeled oxazaphosphorines for applications in mass spectrometry studies. 2. Synthesis of deuterium-labeled 2-dechloroethylcyclo-phosphamides and 2- and 3-dechloroethylifosfamides

Labeled oxazaphosphorines for applications in mass spectrometry studies. 2. Synthesis of deuterium-labeled 2-dechloroethylcyclo-phosphamides and 2- and 3-dechloroethylifosfamides

The prodrugs cyclophosphamide (CP) and ifosfamide (IF) each metabolize to an active alkylating agent through a cytochrome P450-mediated oxidation at the C-4 position. Competing with this activation pathway are enzymatic […]