Why oligonucleotide drugs? Synthetic oligonucleotides are the key factor in almost all molecular biological methodologies. They are used in PCR, reverse transcription, sequencing, gene editing, synthetic biology, cloning, single nucleotide […]
1. Respiratory system 1.1. Lung cancer Drug Name Trade name CAS Target Description Approved Status Gefitinib lressa 184475-35-2 EGFR Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both […]
In 2007, Japanese professors firstly discovered ALK rearrangement and identified the fusion of ALK and EML4 in non-small cell lung cancer specimens. EML4 can promote the activation of ALK kinase […]
In 2001, the FDA approved Imatinib, the first drug to be developed by targeting a specific protein kinase and the first molecularly targeted drug to fight cancer. It was considered […]
MYC protein is an inherently disordered protein, which lacks a hydrophobic pocket or groove suitable for binding small molecule compounds. Currently, no small molecule compounds that can bind MYC have […]
Facing the Coronavirus with continuous mutations, researchers are working hard to develop effective and broad-spectrum anti-Coronavirus drugs and vaccines. At the end of 2021, the small molecule oral drug was […]
Since liposomes have a similar structure to cell membrane, they were used to study the structure and function of biofilms in the early stage. In the late 1960s, Rahman et […]
The Coronavirus outbreak has posed a great threat to human health. Facing the continuous mutation of Coronavirus, researchers are working hard to develop effective and broad-spectrum anti-COVID-19 drugs as well […]
As the basic substance of life, carbohydrate molecules participate in almost all aspects of life activities and play various important biological functions. Based on the extensive biological functions of carbohydrate, […]
Compared with conventional drugs, nucleic acids have great advantages. The mechanism of action and high specificity of nucleic acids provide possible therapeutic approaches for viral infections, various cancers and inoperable […]