On Oct. 18, 2017, the Food and Drug Administration (FDA)’s Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) has unanimously voted 16-0 to support the approval of Novo Nordisk’s semaglutide, a […]
Maintenance of DNA topology is critical for normal DNA replication, transcription and repair in eukaryotic cells. One family of enzymes, the topoisomerases, is essential for this process. Eukaryotic topoisomerase I […]
The main control measures in cotton fields in China include chemical control, cultural control (e.g., intercropping with trap crops), physical control (e.g., light traps and sticky traps), and biological control […]
Acute myeloid leukemia (AML) is a rapidly progressing cancer that forms in the bone marrow and results in an increased number of white blood cells in the bloodstream. The National […]
On July 17, 2017, the U.S. Food and Drug Administration approved neratinib (Nerlynx, Puma Biotechnology, Inc.) for the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer to […]
The concept of arming antibodies by conjugation to protein toxins dates back to 1970, and was followed a few years later by antibody conjugates with cytotoxic drugs. Antibody therapeutics have come of age […]
A systematic comparison of the ginsenosides and physicochemical properties of white ginseng (WG), red ginseng (RG) and black ginseng (BG) was performed. The purpose of the present study was to identify […]
A dynamic microwave-assisted extraction (DMAE) method is established for the extraction of total ginsenosides from ginseng fibrous roots. The extraction process has been simulated and its main affection factors (liquid/solid ratio K of […]
Treosulfan is an alkylating agent that is structurally related to busulfan. It is used in the treatment of ovarian carcinoma and currently considered in clinical trials as a conditioning agent prior to autologous […]
Brain metastasis (BM) is a common complication of lung cancer, and is usually associated with a dismal outcome within a few weeks or months. Non-small cell lung cancer (NSCLC) comprises about 75% of […]