Zotepine - CAS 26615-21-4
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
5-HT Receptor | Dopamine Receptor
Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki = 0.69 and 2.3 nM, respectively) used as an atypical antipsychotic for the treatment of schizophrenia. Zotepine also exhibits an antagonistic effect at histamine H1 receptor (IC50 = 8.0 nM).
Brife Description:
5-HT2A receptor and dopamine D2 receptor antagonist
≥99% by HPLC
Off-White to Pale Yellow Solid
2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine; Nipolept; Lodopin; Zoleptil; Zotepina
Melting Point:
Canonical SMILES:
1.Dose Equivalents for Second-Generation Antipsychotic Drugs: The Classical Mean Dose Method.
Leucht S1, Samara M2, Heres S2, Patel MX3, Furukawa T4, Cipriani A5, Geddes J5, Davis JM6. Schizophr Bull. 2015 Nov;41(6):1397-402. doi: 10.1093/schbul/sbv037. Epub 2015 Apr 3.
BACKGROUND: The concept of dose equivalence is important for many purposes. The classical approach published by Davis in 1974 subsequently dominated textbooks for several decades. It was based on the assumption that the mean doses found in flexible-dose trials reflect the average optimum dose which can be used for the calculation of dose equivalence. We are the first to apply the method to second-generation antipsychotics.
2.XenoSite server: a web-available site of metabolism prediction tool.
Matlock MK1, Hughes TB1, Swamidass SJ1. Bioinformatics. 2015 Apr 1;31(7):1136-7. doi: 10.1093/bioinformatics/btu761. Epub 2014 Nov 18.
Cytochrome P450 enzymes (P450s) are metabolic enzymes that process the majority of FDA-approved, small-molecule drugs. Understanding how these enzymes modify molecule structure is key to the development of safe, effective drugs. XenoSite server is an online implementation of the XenoSite, a recently published computational model for P450 metabolism. XenoSite predicts which atomic sites of a molecule--sites of metabolism (SOMs)--are modified by P450s. XenoSite server accepts input in common chemical file formats including SDF and SMILES and provides tools for visualizing the likelihood that each atomic site is a site of metabolism for a variety of important P450s, as well as a flat file download of SOM predictions.
3.Weight gain and antipsychotics: a drug safety review.
Musil R1, Obermeier M, Russ P, Hamerle M. Expert Opin Drug Saf. 2015 Jan;14(1):73-96. doi: 10.1517/14740338.2015.974549. Epub 2014 Nov 15.
INTRODUCTION: Second-generation antipsychotics (SGAs) are widely used in several psychiatric disease entities and exert to a different extent a risk for antipsychotic-induced weight gain (AIWG). As AIWG is associated with an increase in metabolic syndrome or cardiovascular events, knowledge of these risks is crucial for further monitoring and the initiation of counteractive measures.
4.Use of atypical antipsychotics and risks of cataract development in patients with schizophrenia: A population-based, nested case-control study.
Chou PH1, Chu CS2, Lin CH3, Cheng C4, Chen YH5, Lan TH6, Huang MW7. Schizophr Res. 2016 Apr 6. pii: S0920-9964(16)30120-7. doi: 10.1016/j.schres.2016.03.027. [Epub ahead of print]
OBJECTIVE: Previous research has suggested a link between typical antipsychotic use and the development of cataracts, but the association between atypical antipsychotics and cataracts remains unclear in schizophrenia (SZ).
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CAS 26615-21-4 Zotepine

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