|Targets||5-HT Receptor | Dopamine Receptor|
|Description||Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki = 0.69 and 2.3 nM, respectively) used as an atypical antipsychotic for the treatment of schizophrenia. Zotepine also exhibits an antagonistic effect at histamine H1 receptor (IC50 = 8.0 nM).|
|Brife Description||5-HT2A receptor and dopamine D2 receptor antagonist|
|Purity||≥99% by HPLC|
|Appearance||Off-White to Pale Yellow Solid|
|Synonyms||2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine; Nipolept; Lodopin; Zoleptil; Zotepina|
Ordopidine is a dopaminergic stabilizer. It can inhibit psychostimulant-induced hyperactivity and stimulate behaviour in states of hypoactivity. In May 2016, Ph...
SB 206553 hydrochloride
SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92) with > 80-fold selectivity ...
6,7-Dihydroxy-2-Aminotetraline hydrobromide is a dopamine receptor agonist.
RS 56812 hydrochloride
RS 56812 is a highly potent and selective 5-HT3 partial agonist (pKi= 9.6 in rat brain) with 1000-fold selectivity over a wide range of other neurotransmitter r...
RuBi-Dopa is RuBi-caged dopamine. RuBi-Dopa has a high uncaging efficiency and can be released with visible (blue-green) and IR light in a two-photon regime. It...
SB 243213 dihydrochloride
SB 243213 dihydrochloride is a 5-HT2C inverse agonist (pKb = 9.8) with selectivity over other 5-HT2 subtypes (pKi = 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT...
Pramipexole dihydrochloride monohydrate
Pramipexole is a dopamine agonist with Ki values of 3.9, 2.2, 0.5, 5.1 nM for D2S, D2L, D3 and D4 receptors respectively. It has been used for the treatment of ...
ST-836, a dopamine receptor ligand, might have similar effect with dopamine and probably useful as an antiparkinsonian agent.