Zanamivir - CAS 139110-80-8
Catalog number: B0084-083764
Category: Inhibitor
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Influenza Virus
Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.
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B0084-083764 1 g $469 In stock
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GG167; GG 167; GG-167
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1.Standardizing the influenza neuraminidase inhibition assay among United States public health laboratories conducting virological surveillance.
Okomo-Adhiambo M1, Mishin VP1, Sleeman K1, Saguar E2, Guevara H2, Reisdorf E3, Griesser RH3, Spackman KJ4, Mendenhall M4, Carlos MP5, Healey B5, St George K6, Laplante J6, Aden T7, Chester S7, Xu X1, Gubareva LV8. Antiviral Res. 2016 Apr;128:28-35. doi: 10.1016/j.antiviral.2016.01.009. Epub 2016 Jan 22.
BACKGROUND: Monitoring influenza virus susceptibility to neuraminidase (NA) inhibitors (NAIs) is vital for detecting drug-resistant variants, and is primarily assessed using NA inhibition (NI) assays, supplemented by NA sequence analysis. However, differences in NI testing methodologies between surveillance laboratories results in variability of 50% inhibitory concentration (IC50) values, which impacts data sharing, reporting and interpretation. In 2011, the Centers for Disease Control and Prevention (CDC), in collaboration with the Association for Public Health Laboratories (APHL) spearheaded efforts to standardize fluorescence-based NI assay testing in the United States (U.S.), with the goal of achieving consistency of IC50 data.
2.Susceptibility of influenza viruses circulating in Western Saudi Arabia to neuraminidase inhibitors.
Tolah AM1, Azhar EI, Hashem AM. Saudi Med J. 2016 Apr;37(4):461-5. doi: 10.15537/smj.2016.4.14837.
OBJECTIVES: To investigate the sensitivity of circulating influenza viruses in Western Saudi Arabia to neuraminidase inhibitors (NAIs); mainly, zanamivir and oseltamivir.
3.Characterization of Neuraminidase Inhibitors in Korean Papaver rhoeas Bee Pollen Contributing to Anti-Influenza Activities In Vitro.
Lee IK1, Hwang BS1, Kim DW1, Kim JY1, Woo EE1, Lee YJ1, Choi HJ2, Yun BS1. Planta Med. 2016 Feb 5. [Epub ahead of print]
The active constituents of Korean Papaver rhoeas bee pollen conferring neuraminidase inhibitory activities (H1N1, H3N2, and H5N1) were investigated. Six flavonoids and one alkaloid were isolated and characterized by nuclear magnetic resonance and mass spectrometry data. These included kaempferol-3-sophoroside (1), kaempferol-3-neohesperidoside (2), kaempferol-3-sambubioside (3), kaempferol-3-glucoside (4), quercetin-3-sophoroside (5), luteolin (6), and chelianthifoline (7). All compounds showed neuraminidase inhibitory activities with IC50 values ranging from 10.7 to 151.1 µM. The most potent neuraminidase inhibitor was luteolin, which was the dominant content in the ethyl acetate fraction. All tested compounds displayed noncompetitive inhibition of H3N2 neuraminidase. Furthermore, compounds 1-7 all reduced the severity of virally induced cytopathic effects as determined by the Madin-Darby canine kidney cell-based assay showing antiviral activity with IC50 values ranging from 10.
4.[Comparison of the clinical effectiveness of three neuraminidase inhibitors for Japanese pediatric patients with influenza in the 2013/2014 season].
Hishiki H, Ishiwada N, Naito S, Nagasawa K, Someya T, Inoue N, Haraki M, Kurosaki T, Kameoka Y, Suzuki K. Jpn J Antibiot. 2015 Dec;68(6):337-43.
We investigated the clinical symptoms of 206 pediatric patients with influenza virus infection and compared them among oseltamivir-treated, zanamivir-treated, and laninamivir-treated groups in 2013/2014 influenza season. The drug compliance of each neuraminidase inhibitor was good in all three groups. Although the duration of fever after administration of the first dose of each neuraminidase inhibitor were significantly prolonged in the patient with influenza B infection than in the patient with influenza A infection, no statistically significant difference in the clinical efficacy and the side effect among three groups were found. The number of biphasic fever episodes in patients treated with neuraminidase inhibitor was rare (two episodes of oseltamivir-treated group and one episode of zanamivir-treated group). In conclusion, under the good drug compliance, the efficacy of all three neuraminidase inhibitor was the same for the treatment of influenza virus infection in children.
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