|Description||Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist with higher potency at mGlu4 than mGlu8 (EC50 = 49 and 124 μM, respectively). Z-Cyclopentyl-AP4 selectively inhibits synaptic activity in the lateral perforant pathway (IC50 = 130 and 1859 μM in the lateral and medial perforant pathways, respectively).|
|Brife Description||group III mGlu receptor agonist|
|Purity||≥98% by HPLC|
|Synonyms||cis-(±)-1-Amino-3-phosphonocyclopentane carboxylic acid|
A caged version of (1S,3R)-ACPD. (1S,3R)-ACPD is a group I/II mGlu agonist.
(±)-ADX 71743 has been found to be a negative allosteric modulator at mGlu7 and is brain penetrant.
L-AP4 is a selective group III metabotropic glutamate receptor (mGluR) agonist. It also acts as an agonist at the quisqualate-sensitized AP6 site in hippocampus...
VU 0155041 is a potent positive allosteric modulator at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors, respectively). VU 0155041 displ...
(S)-HexylHIBO is a Group I mGlu receptor antagonist (Kb = 30 and 61 μM at mGlu1a and mGlu5a receptors, respectively).
L-Glutamine is one of the 20 amino acids encoded by the standard genetic code.
Raseglurant is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP. It can be used for the treatment of migraine, gastroesophageal refl...
L-Cysteinesulfinic acid is an agonist of mGlu1a and mGlu5a subtypes expressed in clonal RGT cell lines and an agonist of NMDA. It is used to probe conformationa...