Xanthoxylin - CAS 90-24-4
Catalog number: 90-24-4
Not Intended for Therapeutic Use. For research use only.
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Olaquindox is a natural alkaloid found in the isolated from Cyprinus carpio var. Jian, it has the exhibits the antimicrobial growth accelerants, and is usually used in livestock production to improve feed efficiency.
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1.High sensitivity ELISA determination of taxol in various human biological fluids.
Svojanovsky SR;Egodage KL;Wu J;Slavik M;Wilson GS J Pharm Biomed Anal. 1999 Jul;20(3):549-55.
Taxol (paclitaxel)--the natural product isolated from Pacific yew (Taxus brevifolia)--is a novel agent with high activity in the treatment of patients with several malignant tumors including those resistant to other cytotoxic drugs. The therapeutic index of this promising anticancer drug could be further increased by the exploration of its pharmacokinetic pharmacodynamic relationship in cancer patients. Since taxol is highly protein bound, a very specific and highly sensitive analytical method is required in order to determine free, protein unbound and biologically active taxol species in human physiological fluids: plasma; plasma ultrafiltrate; and salivary fluids. In order to accomplish this, a new indirect competitive enzyme-linked immunosorbent assay (ELISA), for quantitating such a low bioactive taxol concentration level, has been developed in our laboratories. This method uses taxol competitive inhibition of mouse anti-taxol antibodies binding to the solid phase coated antigen 7-succinyltaxol-bovine serum albumin. This indicates recognition of the active taxol in the solution phase, where a diluted horseradish peroxidase labeled goat anti-mouse enzyme conjugate is used. While employing this technique, after systematic optimization of the experimental conditions, we are able to detect the anticipated taxol in plasma ultrafiltrate and salivary fluids at the concentration level of subpicogram per milliliter.
2.The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity.
Douros A;Hadjipavlou-Litina D;Nikolaou K;Skaltsa H Plants (Basel). 2017 Dec 27;7(1). pii: E1. doi: 10.3390/plants7010001.
The phytochemical analysis of the polar extracts of ;Cedrus brevifolia; needles yielded 20 compounds, namely from the methanol extract we isolated three flavonoids (;1;-;3;), one hydrolysable tannin (;4;), eleven phenolic derivatives (;5;-;15;) and one apocarotenoid (;16;), while from the methanol: water (5:1) extract we isolated four flavonoids (;17;-;20;). Chemical structures of all isolated compounds were determined by 1D, 2D-NMR (1 Dimension, 2 Dimensions Nuclear Magnetic Resonance) and UV-Vis (Ultraviolet-Visible) spectroscopy. Furthermore, the antioxidant potentials and the anti-inflammatory activities of both crude extracts and isolates were evaluated through DPPH radical scavenging capability, linoleic acid lipid peroxidation inhibition, and soybean LOX inhibition assays. This is the first report on the chemical profile of ;C. brevifolia; needles. Catechin was the main compound derived from the methanol extract. According to our results, 4-;O;-β-d-glucopyranyl ;trans;-p-coumaric acid and taxifolin were the most active ingredients.
3.Phenolic acids and depsides from some species of the Erodium genera.
Fecka I;Kowalczyk A;Cisowski W Z Naturforsch C. 2001 Nov-Dec;56(11-12):943-50.
Six natural polyphenolic compounds, brevifolin carboxylic acid, brevifolin, ellagic acid, methyl gallate, gallic acid and protocatechuic acid have been isolated from the methanol extract of the whole plant of Erodium cicutarium (L.) L.'Hérit. (Geraniaceae). Structures were determined by conventional methods of analysis and confirmed by MS and NMR spectral analysis. The distribution of these compounds in the other species of the Erodium genera (E. botrys, E. chium, E. ciconium, E. cicutarium, E. glutinosum subsp. dunense, E. gruinum, E. manescavi, E. pelargoniiflorum, E. petraeum) were examined by HPLC with a RP-18 column, and MGD-TLC methods on unmodified silica gel and silica gel chemically modified with polar and nonpolar groups (HPTLC-Si 60 LiChrospher, HPTLC-NH2, HPTLC-DIOL, HPTLC RP-18W).
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CAS 90-24-4 Xanthoxylin

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