VUF 10166 - CAS 155584-74-0
Category: Inhibitor
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Molecular Formula:
C13H15ClN4
Molecular Weight:
262.74
COA:
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Targets:
5-HT Receptor
Description:
VUF 10166 is a potent and competitive 5-HT3 receptor antagonist (IC50 = 0.04 and 22 nM for human 5HT3A and 5-HT3AB receptors, respectively). VUF 10166 exhibits partial agonist activity at 5-HT3A receptors at higher concentrations (EC50 = 5.2 μM). It also acts as a histamine H4 receptor antagonist (pKi = 6.64 in HEK cells).
Brife Description:
5-HT3 receptor antagonist
Purity:
≥98% by HPLC
Synonyms:
VUF 10166; VUF10166; VUF-10166; 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline
MSDS:
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InChIKey:
FFXVTQDGTKEXHF-UHFFFAOYSA-N
InChI:
InChI=1S/C13H15ClN4/c1-17-6-8-18(9-7-17)13-12(14)15-10-4-2-3-5-11(10)16-13/h2-5H,6-9H2,1H3
Canonical SMILES:
CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl
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Chemical Structure

CAS 155584-74-0 VUF 10166

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